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lplA_2 lplA_2 sdhC sdhC sdhA sdhA ACZ32680.1 ACZ32680.1 lipA lipA lpdA lpdA sucC sucC sucD sucD fumC fumC mdh mdh pdhA-2 pdhA-2 pdhA pdhA pdhB pdhB pdhC pdhC sucB sucB sucA sucA gcsH gcsH lplA_1 lplA_1 bfmBB bfmBB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lplA_2Biotin/lipoate A/B protein ligase family protein. (235 aa)
sdhCSdhC protein. (297 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit. (626 aa)
ACZ32680.1Succinate dehydrogenase and fumarate reductase iron-sulfur protein. (258 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (310 aa)
lpdADihydrolipoamide dehydrogenase; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (476 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (460 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
pdhA-2Putative dehydrogenase E1 component, alpha and beta subunit. (678 aa)
pdhAPyruvate dehydrogenase complex E1 component, alpha subunit. (342 aa)
pdhBPyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
pdhCPyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (429 aa)
sucB2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase. (364 aa)
sucA2-oxoglutarate dehydrogenase, E1 component. (908 aa)
gcsHGlycine cleavage system H protein-like protein. (115 aa)
lplA_1Biotin/lipoate A/B protein ligase family protein. (239 aa)
bfmBB2-oxo acid dehydrogenase acyltransferase family protein. (393 aa)
Your Current Organism:
Chlamydia pneumoniae
NCBI taxonomy Id: 406984
Other names: C. pneumoniae LPCoLN, Chlamydia pneumoniae LPCoLN, Chlamydophila pneumoniae LPCoLN, Chlamydophila pneumoniae str. LPCoLN, Chlamydophila pneumoniae strain LPCoLN
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