(74 nodes) Mixed, incl. TOR complex, and Double-strand break repair via nonhomologous end joining network (Capsicum annuum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T459_23253	Transcription factor. (741 aa)
	T459_32467	Smg4_UPF3 domain-containing protein. (485 aa)
	T459_25856	Uncharacterized protein. (138 aa)
	T459_26434	Protein SMG7. (969 aa)
	T459_27543	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (532 aa)
	T459_03300	Cyclin; Belongs to the cyclin family. (219 aa)
	T459_25363	Serine/threonine-protein kinase AtPK1/AtPK6; Belongs to the protein kinase superfamily. (474 aa)
	T459_28705	DNA ligase. (859 aa)
	T459_29645	3-phosphoinositide-dependent protein kinase 2. (493 aa)
	T459_03228	Cyclin; Belongs to the cyclin family. (213 aa)
	T459_21535	Putative ethanolamine kinase. (372 aa)
	T459_05344	Uncharacterized protein. (318 aa)
	T459_05554	Uncharacterized protein. (986 aa)
	T459_08536	Serine/threonine-protein kinase AtPK1/AtPK6; Belongs to the protein kinase superfamily. (471 aa)
	T459_16273	DNA repair protein XRCC4. (263 aa)
	T459_20559	Polynucleotide 3'-phosphatase ZDP. (373 aa)
	T459_32956	Cyclin; Belongs to the cyclin family. (247 aa)
	T459_35714	Uncharacterized protein. (138 aa)
	T459_35682	Uncharacterized protein. (137 aa)
	T459_35671	Uncharacterized protein. (88 aa)
	T459_35068	Putative K(+)-stimulated pyrophosphate-energized sodium pump. (76 aa)
	T459_34920	Putative K(+)-stimulated pyrophosphate-energized sodium pump. (134 aa)
	T459_34755	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (205 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (661 aa)
	T459_32977	Microtubule-binding protein TANGLED1. (472 aa)
	T459_32265	Uncharacterized protein. (328 aa)
	T459_32262	Uncharacterized protein. (228 aa)
	T459_31774	Uncharacterized protein. (1527 aa)
	T459_31677	Uncharacterized protein. (466 aa)
	T459_31680	Uncharacterized protein. (227 aa)
	T459_31604	DNA ligase 4. (746 aa)
	T459_31679	Uncharacterized protein. (226 aa)
	T459_31676	Uncharacterized protein. (388 aa)
	T459_31603	DNA_ligase_A_N domain-containing protein. (150 aa)
	T459_31678	Uncharacterized protein. (161 aa)
	T459_31686	Uncharacterized protein. (281 aa)
	T459_29733	Uncharacterized protein. (155 aa)
	T459_27405	Ku domain-containing protein. (72 aa)
	T459_27508	Uncharacterized protein. (88 aa)
	T459_27598	Ku domain-containing protein. (115 aa)
	T459_28306	Uncharacterized protein. (453 aa)
	T459_28475	Regulator of nonsense transcripts UPF2. (1202 aa)
	T459_26046	Uncharacterized protein. (100 aa)
	T459_23274	PWI domain-containing protein. (818 aa)
	T459_23543	Regulatory-associated protein of TOR 2. (637 aa)
	T459_24097	Uncharacterized protein. (185 aa)
	T459_24098	Ku domain-containing protein. (140 aa)
	T459_21248	60S ribosomal protein L23. (357 aa)
	T459_20007	Cyclin; Belongs to the cyclin family. (196 aa)
	T459_17472	DNA-repair protein XRCC1. (365 aa)
	T459_17748	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (455 aa)
	T459_18109	Uncharacterized protein. (1232 aa)
	T459_18108	Uncharacterized protein. (112 aa)
	T459_11898	Uncharacterized protein. (140 aa)
	T459_12578	Uncharacterized protein. (227 aa)
	T459_07272	ATP-dependent DNA helicase 2 subunit KU70. (749 aa)
	T459_08570	3-phosphoinositide-dependent protein kinase 1. (452 aa)
	T459_08921	Uncharacterized protein. (142 aa)
	T459_08985	Uncharacterized protein. (147 aa)
	T459_09216	EST1_DNA_bind domain-containing protein. (182 aa)
	T459_05339	Uncharacterized protein. (1057 aa)
	T459_05333	Uncharacterized protein. (619 aa)
	T459_05336	Uncharacterized protein. (270 aa)
	T459_05618	Uncharacterized protein. (455 aa)
	T459_05615	Uncharacterized protein. (476 aa)
	T459_05669	Uncharacterized protein. (817 aa)
	T459_05665	Uncharacterized protein. (447 aa)
	T459_05666	Uncharacterized protein. (69 aa)
	T459_06443	DNA ligase. (1421 aa)
	T459_06589	Uncharacterized protein. (449 aa)
	T459_07176	Uncharacterized protein. (422 aa)
	T459_01463	Ku_PK_bind domain-containing protein. (101 aa)
	T459_01462	ATP-dependent DNA helicase 2 subunit KU80. (707 aa)
	T459_04040	Regulator of nonsense transcripts 1-like protein. (1162 aa)

Your Current Organism:

Capsicum annuum

NCBI taxonomy Id: 4072
Other names: C. annuum, Capsicum annuum L., Capsicum sp. HD-HW, Capsicum sp. JYM-2013

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	T459_01462	A0A2G2XYH5	A0A2G3AH96	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ATP-dependent DNA helicase 2 subunit KU80.	0.419
FEN1	T459_01463	A0A2G2XYH5	A0A2G3AH65	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ku_PK_bind domain-containing protein.	0.419
FEN1	T459_06443	A0A2G2XYH5	A0A2G3AAU9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.979
FEN1	T459_07272	A0A2G2XYH5	A0A2G2ZT58	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ATP-dependent DNA helicase 2 subunit KU70.	0.742
FEN1	T459_16273	A0A2G2XYH5	A0A1U8GWB4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA repair protein XRCC4.	0.434
FEN1	T459_17472	A0A2G2XYH5	A0A2G2ZBN0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA-repair protein XRCC1.	0.825
FEN1	T459_20559	A0A2G2XYH5	A0A1U8HCK7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Polynucleotide 3'-phosphatase ZDP.	0.749
FEN1	T459_23253	A0A2G2XYH5	A0A1U8E3V1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Transcription factor.	0.636
FEN1	T459_24097	A0A2G2XYH5	A0A2G2YU92	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.782
FEN1	T459_24098	A0A2G2XYH5	A0A2G2YUA6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ku domain-containing protein.	0.419
FEN1	T459_27405	A0A2G2XYH5	A0A2G2YDU7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ku domain-containing protein.	0.419
FEN1	T459_27543	A0A2G2XYH5	A0A1U8EKH6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.880
FEN1	T459_27598	A0A2G2XYH5	A0A2G2YEW7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ku domain-containing protein.	0.419
FEN1	T459_28705	A0A2G2XYH5	A0A1U8EV20	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.942
FEN1	T459_31603	A0A2G2XYH5	A0A2G2Y461	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA_ligase_A_N domain-containing protein.	0.759
FEN1	T459_31604	A0A2G2XYH5	A0A2G2Y445	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase 4.	0.759
T459_01462	FEN1	A0A2G3AH96	A0A2G2XYH5	ATP-dependent DNA helicase 2 subunit KU80.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.419
T459_01462	T459_03228	A0A2G3AH96	A0A1U8F0D0	ATP-dependent DNA helicase 2 subunit KU80.	Cyclin; Belongs to the cyclin family.	0.733
T459_01462	T459_03300	A0A2G3AH96	A0A1U8EPP7	ATP-dependent DNA helicase 2 subunit KU80.	Cyclin; Belongs to the cyclin family.	0.733
T459_01462	T459_05333	A0A2G3AH96	A0A2G3A7Q4	ATP-dependent DNA helicase 2 subunit KU80.	Uncharacterized protein.	0.468