(27 nodes) Mixed, incl. Porphyrin and chlorophyll metabolism, and FecCD transport family network (Thioploca ingrica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	THII_0102	Oxygen-independent coproporphyrinogen III oxidase HemN; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (462 aa)
	THII_0103	Hypothetical protein. (153 aa)
	THII_0152	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (341 aa)
	hemL	Glutamate-1-semialdehyde aminotransferase. (426 aa)
	cysG	uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (473 aa)
	hemE	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (363 aa)
	THII_1788	Hypothetical protein. (151 aa)
	THII_1789	Ferrichrome transport ATP-binding protein FhuC. (262 aa)
	THII_1790	Fe(3+)-siderophore ABC transporter permease; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (347 aa)
	hemA	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (419 aa)
	hemC	Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa)
	THII_3299	Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (181 aa)
	THII_3410	Hypothetical protein. (144 aa)
	THII_3532	ABC-type Fe3+-hydroxamate transport system, periplasmic component. (318 aa)
	THII_3533	Putative neutral zinc metallopeptidase. (226 aa)
	THII_3534	Hypothetical protein. (309 aa)
	THII_3535	Auxin efflux carrier. (296 aa)
	THII_3536	Hypothetical protein. (155 aa)
	THII_3537	Neutral zinc metallopeptidase. (286 aa)
	hemH	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (368 aa)
	THII_3743	Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (254 aa)
	THII_3807	Transcriptional coactivator/pterin dehydratase. (121 aa)
	THII_3808	Protein involved in sulfur oxidation DsrR. (105 aa)
	THII_3809	Cobyrinic acid a,c-diamide synthase. (476 aa)
	THII_3810	OmpA family protein. (164 aa)
	THII_3811	Hypothetical protein. (471 aa)
	THII_3812	Cytochrome c. (145 aa)

Your Current Organism:

Thioploca ingrica

NCBI taxonomy Id: 40754
Other names: T. ingrica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
THII_0102	THII_0103	THII_0102	THII_0103	Oxygen-independent coproporphyrinogen III oxidase HemN; Belongs to the anaerobic coproporphyrinogen-III oxidase family.	Hypothetical protein.	0.732
THII_0102	THII_3410	THII_0102	THII_3410	Oxygen-independent coproporphyrinogen III oxidase HemN; Belongs to the anaerobic coproporphyrinogen-III oxidase family.	Hypothetical protein.	0.909
THII_0102	hemE	THII_0102	THII_1278	Oxygen-independent coproporphyrinogen III oxidase HemN; Belongs to the anaerobic coproporphyrinogen-III oxidase family.	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.	0.946
THII_0103	THII_0102	THII_0103	THII_0102	Hypothetical protein.	Oxygen-independent coproporphyrinogen III oxidase HemN; Belongs to the anaerobic coproporphyrinogen-III oxidase family.	0.732
THII_0152	THII_3743	THII_0152	THII_3743	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.	0.913
THII_0152	THII_3809	THII_0152	THII_3809	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	Cobyrinic acid a,c-diamide synthase.	0.579
THII_0152	cysG	THII_0152	THII_0982	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.	0.913
THII_0152	hemA	THII_0152	THII_2841	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).	0.870
THII_0152	hemC	THII_0152	THII_3233	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.	0.996
THII_0152	hemE	THII_0152	THII_1278	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.	0.800
THII_0152	hemH	THII_0152	THII_3715	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	0.498
THII_0152	hemL	THII_0152	THII_0726	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	Glutamate-1-semialdehyde aminotransferase.	0.992
THII_1789	THII_1790	THII_1789	THII_1790	Ferrichrome transport ATP-binding protein FhuC.	Fe(3+)-siderophore ABC transporter permease; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.999
THII_1789	THII_3532	THII_1789	THII_3532	Ferrichrome transport ATP-binding protein FhuC.	ABC-type Fe3+-hydroxamate transport system, periplasmic component.	0.990
THII_1789	THII_3809	THII_1789	THII_3809	Ferrichrome transport ATP-binding protein FhuC.	Cobyrinic acid a,c-diamide synthase.	0.485
THII_1790	THII_1789	THII_1790	THII_1789	Fe(3+)-siderophore ABC transporter permease; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Ferrichrome transport ATP-binding protein FhuC.	0.999
THII_1790	THII_3532	THII_1790	THII_3532	Fe(3+)-siderophore ABC transporter permease; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	ABC-type Fe3+-hydroxamate transport system, periplasmic component.	0.997
THII_1790	cysG	THII_1790	THII_0982	Fe(3+)-siderophore ABC transporter permease; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.	0.499
THII_3299	THII_3809	THII_3299	THII_3809	Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.	Cobyrinic acid a,c-diamide synthase.	0.938
THII_3299	cysG	THII_3299	THII_0982	Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.	uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.	0.417