STRINGSTRING
THII_3413 THII_3413 THII_3911 THII_3911 coaX coaX THII_3902 THII_3902 THII_3889 THII_3889 THII_3835 THII_3835 THII_3834 THII_3834 THII_3833 THII_3833 THII_3825 THII_3825 THII_3792 THII_3792 THII_3790 THII_3790 THII_3768 THII_3768 THII_3734 THII_3734 THII_3722 THII_3722 THII_3682 THII_3682 THII_3648 THII_3648 THII_3614 THII_3614 THII_3469 THII_3469 THII_3468 THII_3468 THII_3467 THII_3467 THII_3448 THII_3448 THII_3447 THII_3447 aroK aroK THII_3415 THII_3415 gmk gmk THII_3345 THII_3345 pgk pgk THII_3339 THII_3339 THII_3225 THII_3225 THII_3181 THII_3181 THII_3145 THII_3145 THII_3067 THII_3067 THII_3062 THII_3062 THII_3043 THII_3043 THII_3042 THII_3042 THII_3036 THII_3036 THII_3035 THII_3035 THII_3033 THII_3033 THII_2976 THII_2976 THII_2975 THII_2975 THII_2972 THII_2972 THII_2969 THII_2969 ppk ppk THII_2963 THII_2963 THII_2951 THII_2951 THII_2909 THII_2909 THII_2907 THII_2907 ackA ackA THII_2817 THII_2817 THII_2816 THII_2816 THII_2753 THII_2753 nadK nadK THII_2622 THII_2622 adk adk THII_2582 THII_2582 THII_2580 THII_2580 THII_2571 THII_2571 THII_2555 THII_2555 THII_2528 THII_2528 THII_2440 THII_2440 THII_2407 THII_2407 THII_2375 THII_2375 THII_2341 THII_2341 THII_2325 THII_2325 ispE ispE prs prs THII_2294 THII_2294 THII_2275 THII_2275 THII_2238 THII_2238 THII_2182 THII_2182 THII_2177 THII_2177 THII_2169 THII_2169 THII_2168 THII_2168 anmK anmK proB proB THII_1988 THII_1988 coaE coaE THII_1954 THII_1954 THII_1951 THII_1951 THII_1949 THII_1949 THII_1928 THII_1928 THII_1884 THII_1884 THII_1849 THII_1849 THII_1847 THII_1847 THII_1779 THII_1779 THII_1777 THII_1777 THII_1776 THII_1776 THII_1773 THII_1773 pyrH pyrH THII_1631 THII_1631 THII_1625 THII_1625 thrB thrB THII_1585 THII_1585 THII_1571 THII_1571 THII_1563 THII_1563 THII_1540 THII_1540 THII_1514 THII_1514 THII_1495 THII_1495 THII_1454 THII_1454 thiL thiL lpxK lpxK THII_1426 THII_1426 ndk ndk THII_1395 THII_1395 THII_1365 THII_1365 THII_1364 THII_1364 THII_1327 THII_1327 THII_1301 THII_1301 THII_1288 THII_1288 THII_1284 THII_1284 THII_1283 THII_1283 hprK hprK THII_1243 THII_1243 THII_1191 THII_1191 THII_1161 THII_1161 THII_1131 THII_1131 THII_1128 THII_1128 THII_1121 THII_1121 THII_1052 THII_1052 THII_1036 THII_1036 THII_1020 THII_1020 THII_1019 THII_1019 THII_0968 THII_0968 THII_0937 THII_0937 THII_0921 THII_0921 THII_0877 THII_0877 THII_0803 THII_0803 THII_0798 THII_0798 THII_0777 THII_0777 THII_0775 THII_0775 THII_0774 THII_0774 THII_0770 THII_0770 THII_0751 THII_0751 THII_0750 THII_0750 THII_0714 THII_0714 THII_0687 THII_0687 THII_0636 THII_0636 argB argB THII_0555 THII_0555 THII_0554 THII_0554 THII_0541 THII_0541 cysC cysC THII_0500 THII_0500 THII_0444 THII_0444 THII_0443 THII_0443 THII_0440 THII_0440 THII_0402 THII_0402 THII_0393 THII_0393 pfp pfp THII_0354 THII_0354 THII_0350 THII_0350 THII_0331 THII_0331 THII_0328 THII_0328 THII_0268 THII_0268 THII_0267 THII_0267 THII_0242 THII_0242 THII_0196 THII_0196 THII_0189 THII_0189 glk glk THII_0123 THII_0123 THII_0113 THII_0113 hldE hldE pckA pckA THII_0051 THII_0051 THII_0050 THII_0050 cmk cmk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THII_3413PAS domain S-box. (920 aa)
THII_3911Diguanylate cyclase/phosphodiesterase. (702 aa)
coaXTranscriptional regulator; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (252 aa)
THII_3902Response regulator receiver protein. (131 aa)
THII_3889Sensor histidine kinase FexB. (1347 aa)
THII_3835Sensor protein. (806 aa)
THII_3834Sensory transduction histidine kinase. (952 aa)
THII_3833Response regulator receiver protein. (385 aa)
THII_3825Sensor histidine kinase. (724 aa)
THII_3792Signal transduction histidine kinase. (518 aa)
THII_3790Serine/threonine protein kinase. (1788 aa)
THII_3768Diguanylate cyclase/phosphodiesterase. (1693 aa)
THII_3734Response regulator receiver. (1455 aa)
THII_3722Two-component hybrid sensor and regulator. (588 aa)
THII_3682Response regulator receiver domain-containing protein. (1502 aa)
THII_3648Hypothetical protein. (659 aa)
THII_3614Signal transduction histidine kinase. (876 aa)
THII_3469Signal transduction histidine kinase. (1432 aa)
THII_3468ATPase. (2106 aa)
THII_3467Two-component hybrid sensor and regulator. (420 aa)
THII_3448Response regulator receiver sensor hybrid histidine kinase. (535 aa)
THII_3447PAS domain S-box. (1392 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (186 aa)
THII_3415Histidine kinase-like protein. (412 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa)
THII_3345Response regulator receiver protein. (566 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
THII_3339Pyruvate kinase; Belongs to the pyruvate kinase family. (480 aa)
THII_3225Hypothetical protein. (864 aa)
THII_3181Cache domain protein. (167 aa)
THII_3145Signal transduction histidine kinase. (1265 aa)
THII_3067Histidine kinase. (574 aa)
THII_3062Sensor kinase protein. (458 aa)
THII_3043Sensor histidine kinase/response regulator. (581 aa)
THII_3042Two-component sensor serine/threonine kinase. (1823 aa)
THII_3036Protein kinase family protein. (876 aa)
THII_3035PfkB domain-containing protein. (307 aa)
THII_3033Phosphate regulon sensor kinase PhoR. (442 aa)
THII_2976PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein. (1278 aa)
THII_2975Two-component hybrid sensor and regulator. (361 aa)
THII_2972Histidine kinase. (78 aa)
THII_2969Signal transduction histidine kinase. (722 aa)
ppkPolyphosphate kinase 1; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (719 aa)
THII_2963PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein. (875 aa)
THII_2951Hypothetical protein. (230 aa)
THII_2909Phosphotransferase system, mannose/fructose-specific component IIA. (132 aa)
THII_2907Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (576 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (391 aa)
THII_2817Adenosine kinase. (314 aa)
THII_2816Sugar kinase. (313 aa)
THII_2753Histidine kinase. (537 aa)
nadKSugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (290 aa)
THII_2622Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (924 aa)
adkAdenylate kinase family protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
THII_2582Signal transduction histidine kinase. (769 aa)
THII_2580Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. (713 aa)
THII_2571PAS/PAC sensor signal transduction histidine kinase. (519 aa)
THII_2555Histidine kinase. (399 aa)
THII_2528Signal transduction histidine kinase. (1225 aa)
THII_2440Multi-sensor hybrid histidine kinase. (1218 aa)
THII_2407Sensor signal transduction histidine kinase. (705 aa)
THII_2375ATPase. (1826 aa)
THII_2341Phosphomethylpyrimidine kinase. (271 aa)
THII_2325Sensory box sensor histidine kinase/response regulator. (1109 aa)
ispE4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (278 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (311 aa)
THII_2294PAS domain S-box. (860 aa)
THII_2275Hydroxypyruvate reductase. (413 aa)
THII_2238Phosphoenolpyruvate synthase. (778 aa)
THII_2182Ketohexokinase. (294 aa)
THII_2177Chemotaxis protein histidine kinase CheA. (768 aa)
THII_2169Signal transduction histidine kinase. (614 aa)
THII_2168Signal transduction histidine kinase. (1615 aa)
anmKHypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (366 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa)
THII_1988Chemotaxis protein histidine kinase-like protein. (2471 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa)
THII_1954Signal transduction histidine kinase. (1702 aa)
THII_1951GAF sensor hybrid histidine kinase. (1584 aa)
THII_1949Signal transduction histidine kinase. (1257 aa)
THII_1928Response regulator receiver domain protein. (929 aa)
THII_1884Hypothetical protein. (849 aa)
THII_1849Two-component hybrid sensor and regulator. (368 aa)
THII_1847Signal transduction histidine kinase. (488 aa)
THII_1779ATPase. (329 aa)
THII_1777Signal transduction histidine kinase. (1093 aa)
THII_1776PAS domain-containing protein. (777 aa)
THII_1773Riboflavin biosynthesis protein ribF; Belongs to the ribF family. (308 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (242 aa)
THII_1631Signal transduction histidine kinase. (497 aa)
THII_1625Histidine kinase. (558 aa)
thrBHomoserine kinase; Belongs to the pseudomonas-type ThrB family. (308 aa)
THII_1585Two-component sensor histidine kinase protein. (491 aa)
THII_1571Osmosensitive K channel His kinase sensor. (909 aa)
THII_15632-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (165 aa)
THII_1540PAS domain-containing protein. (1313 aa)
THII_1514Putative ATPase. (1775 aa)
THII_1495RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (737 aa)
THII_1454Multi-sensor signal transduction multi-kinase. (1761 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (330 aa)
lpxKtetraacyldisaccharide-1-P 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (332 aa)
THII_1426Hypothetical protein; Belongs to the UPF0434 family. (62 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
THII_1395PAS domain-containing protein. (2313 aa)
THII_1365PAS/PAC sensor hybrid histidine kinase. (1342 aa)
THII_1364Sensor diguanylate cyclase/phosphodiesterase, GAF and PAS domain-containing. (1140 aa)
THII_1327Chain length determinant protein. (702 aa)
THII_1301Signal transduction histidine kinase. (731 aa)
THII_1288Pilus response regulator PilG. (134 aa)
THII_1284Hypothetical protein. (559 aa)
THII_1283Chemotaxis protein histidine kinase-like protein. (1251 aa)
hprKSerine kinase of the HPr protein; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). (318 aa)
THII_1243Response regulator receiver. (1471 aa)
THII_1191PAS domain S-box. (723 aa)
THII_1161Signal transduction histidine kinase. (894 aa)
THII_1131Histidine kinase-like protein. (1199 aa)
THII_1128Serine/threonine protein kinase. (480 aa)
THII_1121Sensory transduction protein kinase. (493 aa)
THII_1052Von Willebrand factor type A. (278 aa)
THII_1036Signal transduction histidine kinase. (1814 aa)
THII_1020Signal transduction histidine kinase. (1208 aa)
THII_1019Signal transduction histidine kinase. (591 aa)
THII_0968Signal transduction histidine kinase. (695 aa)
THII_0937Response regulator receiver and Hpt phospho transfer protein. (128 aa)
THII_0921Putative hybrid histidine kinase. (950 aa)
THII_0877Sensory box/GGDEF family protein. (581 aa)
THII_0803Histidine kinase. (397 aa)
THII_0798Capsular exopolysaccharide biosynthesis protein. (738 aa)
THII_0777Diguanylate cyclase/phosphodiesterase. (1099 aa)
THII_0775Response regulator receiver protein. (364 aa)
THII_0774Sensory box histidine kinase/response regulator. (1396 aa)
THII_0770Phosphoribulokinase. (292 aa)
THII_0751PAS domain S-box. (809 aa)
THII_0750Signal transduction histidine kinase. (1182 aa)
THII_0714Polyphosphate glucokinase. (261 aa)
THII_0687Putative regulator of cell autolysis. (370 aa)
THII_0636Signal transduction histidine kinase. (1784 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa)
THII_0555Response regulator receiver protein. (122 aa)
THII_0554CheA signal transduction histidine kinase. (676 aa)
THII_0541Family 3 adenylate cyclase. (177 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (207 aa)
THII_0500ATPase. (1989 aa)
THII_0444Signal transduction histidine kinase. (438 aa)
THII_0443Response regulator receiver protein. (1717 aa)
THII_0440Serine/threonine protein kinase. (456 aa)
THII_0402Hypothetical protein. (210 aa)
THII_03932-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. (157 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (422 aa)
THII_0354Two-component hybrid sensor and regulator. (372 aa)
THII_0350Multi-sensor hybrid histidine kinase. (696 aa)
THII_0331PAS domain S-box. (1713 aa)
THII_0328Serine/threonine protein kinase. (508 aa)
THII_0268Histidine kinase. (767 aa)
THII_0267Signal transduction histidine kinase. (617 aa)
THII_0242Diacylglycerol kinase, catalytic region. (298 aa)
THII_0196Aspartate kinase, monofunctional class; Belongs to the aspartokinase family. (407 aa)
THII_0189Signal transduction histidine kinase. (693 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (342 aa)
THII_0123Hypothetical protein. (302 aa)
THII_0113Hypothetical protein. (326 aa)
hldEBifunctional protein hldE; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (477 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (534 aa)
THII_0051Multi-sensor hybrid histidine kinase. (130 aa)
THII_0050PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein. (701 aa)
cmkCytidylate kinase. (228 aa)
Your Current Organism:
Thioploca ingrica
NCBI taxonomy Id: 40754
Other names: T. ingrica
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