STRINGSTRING
THII_0061 THII_0061 hldE hldE coaD coaD rpoZ rpoZ rpoA rpoA rpoC rpoC ispD ispD THII_0470 THII_0470 THII_0574 THII_0574 kdsB kdsB THII_0729 THII_0729 THII_0760 THII_0760 sat sat THII_1133 THII_1133 pnp pnp THII_1254 THII_1254 polA polA THII_1302 THII_1302 THII_1307 THII_1307 dnaQ dnaQ THII_1346 THII_1346 glgC glgC THII_1541 THII_1541 pcnB pcnB cca cca THII_1695 THII_1695 THII_1742 THII_1742 glmU glmU THII_1773 THII_1773 mobA mobA dnaG dnaG THII_1956 THII_1956 THII_2044 THII_2044 THII_2179 THII_2179 THII_2246 THII_2246 glnE glnE THII_2367 THII_2367 tsaC tsaC THII_2614 THII_2614 THII_2615 THII_2615 THII_2616 THII_2616 THII_2693 THII_2693 THII_2699 THII_2699 rpoB rpoB rpoC-2 rpoC-2 dnaX dnaX THII_2864 THII_2864 THII_2898 THII_2898 THII_2899 THII_2899 THII_3008 THII_3008 THII_3020 THII_3020 THII_3049 THII_3049 THII_3057 THII_3057 THII_3141 THII_3141 THII_3412 THII_3412 glnD glnD rph rph THII_3793 THII_3793 THII_3814 THII_3814 nadD nadD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THII_0061Hypothetical protein. (430 aa)
hldEBifunctional protein hldE; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (477 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
rpoZRNA polymerase Rpb6; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (74 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (334 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1419 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (247 aa)
THII_0470MobA-like protein. (189 aa)
THII_0574CRISPR-associated Csh2 family protein. (317 aa)
kdsBAcylneuraminate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (249 aa)
THII_0729DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (370 aa)
THII_0760Glycosyltransferase, group 2 family protein. (478 aa)
satSulfate adenylyltransferase; Belongs to the sulfate adenylyltransferase family. (398 aa)
THII_1133UTP-glucose-1-phosphate uridylyltransferase. (298 aa)
pnpPolynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (697 aa)
THII_1254DNA-directed RNA polymerase specialized sigma subunit, sigma54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (515 aa)
polADNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (910 aa)
THII_1302Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (173 aa)
THII_1307DNA polymerase III chi subunit, HolC. (144 aa)
dnaQDNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (237 aa)
THII_1346Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (291 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (424 aa)
THII_1541Diguanylate cyclase. (321 aa)
pcnBpoly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (473 aa)
ccatRNA nucleotidyl transferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (413 aa)
THII_1695Glucose-1-phosphate cytidylyltransferase. (323 aa)
THII_1742CDP-diglyceride synthetase; Belongs to the CDS family. (276 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (454 aa)
THII_1773Riboflavin biosynthesis protein ribF; Belongs to the ribF family. (308 aa)
mobAMolybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (198 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (577 aa)
THII_1956Response regulator. (301 aa)
THII_2044Hypothetical protein. (864 aa)
THII_2179DNA polymerase III subunit delta'. (350 aa)
THII_2246Hypothetical protein. (408 aa)
glnEGlutamine synthetase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transducti [...] (963 aa)
THII_2367Mannose-1-phosphate guanylyltransferase. (222 aa)
tsaCSUA5/yciO/yrdC domain-containing protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. (196 aa)
THII_2614Hypothetical protein. (169 aa)
THII_2615Hypothetical protein. (137 aa)
THII_2616Hypothetical protein. (113 aa)
THII_2693Diguanylate cyclase. (340 aa)
THII_2699Pilus response regulator PilG. (133 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1392 aa)
rpoC-2RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1400 aa)
dnaXDNA polymerase III; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (523 aa)
THII_2864DNA polymerase beta domain-containing protein. (108 aa)
THII_2898Hypothetical protein. (137 aa)
THII_2899Hypothetical protein. (169 aa)
THII_3008DNA polymerase III subunit alpha. (1153 aa)
THII_3020Diguanylate cyclase (GGDEF) domain-containing protein. (448 aa)
THII_3049DNA polymerase III subunit delta. (344 aa)
THII_3057Mannose-1-phosphate guanyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (470 aa)
THII_3141Periplasmic ligand-binding sensor domain-containing protein. (560 aa)
THII_3412Hypothetical protein. (287 aa)
glnDUTP-GlnB uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (902 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (239 aa)
THII_3793Diguanylate cyclase (GGDEF) domain-containing protein. (334 aa)
THII_3814Putative signal-transduction protein containing cAMP-binding and CBS domains. (608 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (217 aa)
Your Current Organism:
Thioploca ingrica
NCBI taxonomy Id: 40754
Other names: T. ingrica
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