(43 nodes) Sterol biosynthetic process network (Nicotiana sylvestris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC104213731	Methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. (346 aa)
	LOC104211830	Squalene synthase-like. (411 aa)
	LOC104211738	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family. (342 aa)
	LOC104220250	Mevalonate kinase. (385 aa)
	LOC104248444	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (463 aa)
	LOC104248019	Sterol 3-beta-glucosyltransferase UGT80A2-like isoform X1. (631 aa)
	LOC104247475	Methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. (357 aa)
	LOC104247011	Mevalonate kinase. (387 aa)
	LOC104248706	Methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. (349 aa)
	LOC104249643	7-dehydrocholesterol reductase. (434 aa)
	LOC104248076	Squalene synthase. (411 aa)
	LOC104245967	Reticulon-like protein. (585 aa)
	LOC104246352	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (462 aa)
	LOC104241768	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Belongs to the diphosphomevalonate decarboxylase family. (421 aa)
	LOC104246060	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family. (302 aa)
	LOC104243538	Sterol 3-beta-glucosyltransferase UGT80A2-like isoform X1. (627 aa)
	LOC104243678	LOW QUALITY PROTEIN: probable phosphomevalonate kinase. (511 aa)
	LOC104239765	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Belongs to the diphosphomevalonate decarboxylase family. (421 aa)
	LOC104239655	Reticulon-like protein. (561 aa)
	LOC104234035	Probable 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase. (221 aa)
	LOC104234010	3-hydroxy-3-methylglutaryl coenzyme A reductase. (589 aa)
	LOC104236837	Ergosterol biosynthetic protein 28. (129 aa)
	LOC104235251	delta(7)-sterol-C5(6)-desaturase; Belongs to the sterol desaturase family. (271 aa)
	LOC104230596	delta(7)-sterol-C5(6)-desaturase-like; Belongs to the sterol desaturase family. (271 aa)
	LOC104232898	Squalene epoxidase 3-like. (613 aa)
	LOC104234654	Cytochrome P450 710A1-like; Belongs to the cytochrome P450 family. (506 aa)
	LOC104233478	Methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. (357 aa)
	LOC104229786	3-hydroxy-3-methylglutaryl coenzyme A reductase. (605 aa)
	LOC104231859	3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2-like. (134 aa)
	LOC104225605	Methylsterol monooxygenase 1-1-like; Belongs to the sterol desaturase family. (301 aa)
	LOC104229080	Sterol 3-beta-glucosyltransferase UGT80A2-like. (625 aa)
	LOC104227542	Methylsterol monooxygenase 1-1-like; Belongs to the sterol desaturase family. (300 aa)
	LOC104224029	Squalene epoxidase 3-like isoform X1. (516 aa)
	LOC104225983	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (462 aa)
	LOC104220676	Squalene synthase-like. (398 aa)
	LOC104219987	Sterol 3-beta-glucosyltransferase UGT80B1 isoform X1. (667 aa)
	LOC104215944	Delta(14)-sterol reductase. (369 aa)
	LOC104216879	3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1-like; Belongs to the 3-beta-HSD family. (306 aa)
	LOC104216953	Phosphomevalonate kinase-like. (510 aa)
	LOC104216370	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family. (342 aa)
	LOC104213055	Methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. (357 aa)
	LOC104212796	Squalene synthase-like. (406 aa)
	LOC104211864	Squalene monooxygenase-like. (528 aa)

Your Current Organism:

Nicotiana sylvestris

NCBI taxonomy Id: 4096
Other names: N. sylvestris, Nicotiana sylvestris Speg. & Comes, wood tobacco

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC104211738	LOC104211830	A0A1U7UY95	A0A1U7V2S2	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Squalene synthase-like.	0.901
LOC104211738	LOC104212796	A0A1U7UY95	A0A1U7V652	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Squalene synthase-like.	0.837
LOC104211738	LOC104215944	A0A1U7UY95	A0A1U7VQM5	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Delta(14)-sterol reductase.	0.580
LOC104211738	LOC104216370	A0A1U7UY95	A0A1U7V9H7	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	0.900
LOC104211738	LOC104216953	A0A1U7UY95	A0A1U7VBJ0	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Phosphomevalonate kinase-like.	0.432
LOC104211738	LOC104220250	A0A1U7UY95	S5NWP1	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Mevalonate kinase.	0.504
LOC104211738	LOC104220676	A0A1U7UY95	A0A1U7W6K1	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Squalene synthase-like.	0.851
LOC104211738	LOC104225983	A0A1U7UY95	A0A1U7WBZ4	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.763
LOC104211738	LOC104229786	A0A1U7UY95	A0A1U7WU04	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.802
LOC104211738	LOC104234010	A0A1U7UY95	A0A1U7XH59	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.704
LOC104211738	LOC104234035	A0A1U7UY95	A0A1U7XH78	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Probable 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase.	0.457
LOC104211738	LOC104239765	A0A1U7UY95	A0A1U7XPI2	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Belongs to the diphosphomevalonate decarboxylase family.	0.969
LOC104211738	LOC104241768	A0A1U7UY95	A0A1U7Y867	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Belongs to the diphosphomevalonate decarboxylase family.	0.969
LOC104211738	LOC104243678	A0A1U7UY95	A0A1U7XZ08	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	LOW QUALITY PROTEIN: probable phosphomevalonate kinase.	0.432
LOC104211738	LOC104246060	A0A1U7UY95	A0A1U7Y7J2	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	0.900
LOC104211738	LOC104246352	A0A1U7UY95	A0A1U7YBG2	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.752
LOC104211738	LOC104247011	A0A1U7UY95	A0A1U7YQX8	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Mevalonate kinase.	0.504
LOC104211738	LOC104248076	A0A1U7UY95	A0A1U7YHG1	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	Squalene synthase.	0.954
LOC104211738	LOC104248444	A0A1U7UY95	A0A1U7YW78	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.752
LOC104211738	LOC104249643	A0A1U7UY95	A0A1U7YK08	Farnesyl pyrophosphate synthase 1-like; Belongs to the FPP/GGPP synthase family.	7-dehydrocholesterol reductase.	0.608