(48 nodes) Phenylalanine ammonia-lyase, and Flavonoid biosynthesis network (Nicotiana tabacum)

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	LOC107816628	cinnamoyl-CoA reductase 1-like. (332 aa)
	LOC107761111	4-coumarate--CoA ligase 2-like. (546 aa)
	LOC107761482	Phenylalanine ammonia-lyase. (715 aa)
	LOC107766072	4-coumarate--CoA ligase 2-like. (542 aa)
	LOC107767884	4-coumarate--CoA ligase 2-like. (549 aa)
	LOC107769758	4-coumarate--CoA ligase 2-like. (571 aa)
	LOC107770611	caffeoyl-CoA O-methyltransferase 5. (240 aa)
	LOC107772942	Shikimate O-hydroxycinnamoyltransferase-like. (436 aa)
	LOC107779684	caffeoyl-CoA O-methyltransferase 3-like. (244 aa)
	LOC107781854	Cytochrome P450 CYP73A100-like; Belongs to the cytochrome P450 family. (537 aa)
	LOC107786762	Phenylalanine ammonia-lyase. (712 aa)
	LOC107789328	caffeoyl-CoA O-methyltransferase 3. (242 aa)
	LOC107790326	4-coumarate--CoA ligase-like 9. (549 aa)
	LOC107792528	Probable caffeoyl-CoA O-methyltransferase At4g26220. (235 aa)
	LOC107792668	Phenylalanine ammonia-lyase. (712 aa)
	LOC107792922	Caffeoylshikimate esterase-like. (327 aa)
	LOC107793030	4-coumarate--CoA ligase-like 6. (565 aa)
	LOC107794305	Flavonol synthase/flavanone 3-hydroxylase; Belongs to the iron/ascorbate-dependent oxidoreductase family. (338 aa)
	LOC107797035	4-coumarate--CoA ligase-like 7. (538 aa)
	LOC107797097	caffeoyl-CoA O-methyltransferase 5-like. (240 aa)
	LOC107798422	4-coumarate--CoA ligase-like 7. (538 aa)
	LOC107799225	Probable caffeoyl-CoA O-methyltransferase At4g26220 isoform X1. (236 aa)
	LOC107802063	Phenylalanine ammonia-lyase. (717 aa)
	LOC107803673	4-coumarate--CoA ligase 1. (547 aa)
	LOC107803813	4-coumarate--CoA ligase-like 1. (551 aa)
	LOC107809744	Chalcone synthase 2; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (389 aa)
	LOC107812882	Trans-cinnamate 4-monooxygenase-like; Belongs to the cytochrome P450 family. (506 aa)
	LOC107813425	Chalcone synthase J-like isoform X1; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (390 aa)
	LOC107813613	Chalcone synthase A; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (389 aa)
	LOC107814113	4-coumarate--CoA ligase-like 1. (551 aa)
	LOC107815050	cinnamoyl-CoA reductase 1-like. (272 aa)
	LOC107820497	Phenylalanine ammonia-lyase. (717 aa)
	LOC107823514	Trans-cinnamate 4-monooxygenase-like; Belongs to the cytochrome P450 family. (506 aa)
	LOC107826655	4-coumarate--CoA ligase-like 6 isoform X1. (565 aa)
	LOC107831213	Phenylalanine ammonia-lyase. (719 aa)
	LOC107831218	4-coumarate--CoA ligase 2-like. (569 aa)
	LOC107832128	Probable caffeoyl-CoA O-methyltransferase At4g26220. (230 aa)
	LOC107832236	Chalcone synthase G-like; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (390 aa)
	LOC107826530	Trans-cinnamate 4-monooxygenase; Belongs to the cytochrome P450 family. (505 aa)
	LOC107791262	Trans-cinnamate 4-monooxygenase-like; Belongs to the cytochrome P450 family. (505 aa)
	pal4	Phenylalanine ammonia-lyase. (717 aa)
	TPA1	Phenylalanine ammonia-lyase; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family. (715 aa)
	PALA	Phenylalanine ammonia-lyase; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton. (712 aa)
	NtPAL	Phenylalanine ammonia-lyase; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family. (712 aa)
	CCOAOMT6	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily. (247 aa)
	HST	Shikimate O-hydroxycinnamoyltransferase; Acyltransferase involved in the biosynthesis of lignin. The affinity for shikimate as acceptor is 100-fold higher than for quinate. The most efficient donors are caffeoyl-CoA > p-coumaroyl-CoA > feruloyl-CoA >> sinapoyl-CoA. (435 aa)
	LOC107801774	Chalcone synthase 1B-like; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (389 aa)
	CYP73A28	Elicitor-inducible cytochrome P450; Belongs to the cytochrome P450 family. (534 aa)

Your Current Organism:

Nicotiana tabacum

NCBI taxonomy Id: 4097
Other names: American tobacco, N. tabacum, Nicotiana tabacum L., common tobacco, tobacco

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCOAOMT6	CYP73A28	Q42945	Q94FM4	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	Elicitor-inducible cytochrome P450; Belongs to the cytochrome P450 family.	0.484
CCOAOMT6	HST	Q42945	Q8GSM7	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	Shikimate O-hydroxycinnamoyltransferase; Acyltransferase involved in the biosynthesis of lignin. The affinity for shikimate as acceptor is 100-fold higher than for quinate. The most efficient donors are caffeoyl-CoA > p-coumaroyl-CoA > feruloyl-CoA >> sinapoyl-CoA.	0.830
CCOAOMT6	LOC107761111	Q42945	A0A1S3X4W9	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	4-coumarate--CoA ligase 2-like.	0.886
CCOAOMT6	LOC107761482	Q42945	A0A1S3X5R5	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	Phenylalanine ammonia-lyase.	0.640
CCOAOMT6	LOC107766072	Q42945	A0A1S3XK13	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	4-coumarate--CoA ligase 2-like.	0.880
CCOAOMT6	LOC107767884	Q42945	A0A1S3XRA5	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	4-coumarate--CoA ligase 2-like.	0.886
CCOAOMT6	LOC107769758	Q42945	A0A1S3XX23	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	4-coumarate--CoA ligase 2-like.	0.889
CCOAOMT6	LOC107772942	Q42945	A0A1S3Y756	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	Shikimate O-hydroxycinnamoyltransferase-like.	0.697
CCOAOMT6	LOC107781854	Q42945	A0A1S3Z168	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	Cytochrome P450 CYP73A100-like; Belongs to the cytochrome P450 family.	0.484
CCOAOMT6	LOC107786762	Q42945	A0A1S3ZH48	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	Phenylalanine ammonia-lyase.	0.737
CCOAOMT6	LOC107790326	Q42945	A0A1S3ZTJ1	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	4-coumarate--CoA ligase-like 9.	0.896
CCOAOMT6	LOC107791262	Q42945	A1XEL2	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	Trans-cinnamate 4-monooxygenase-like; Belongs to the cytochrome P450 family.	0.494
CCOAOMT6	LOC107792668	Q42945	A0A1S4A1B2	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	Phenylalanine ammonia-lyase.	0.737
CCOAOMT6	LOC107792922	Q42945	A0A1S4A248	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	Caffeoylshikimate esterase-like.	0.547
CCOAOMT6	LOC107793030	Q42945	A0A1S4A2D2	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	4-coumarate--CoA ligase-like 6.	0.883
CCOAOMT6	LOC107794305	Q42945	A0A1S4A6K1	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	Flavonol synthase/flavanone 3-hydroxylase; Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.592
CCOAOMT6	LOC107797035	Q42945	A0A1S4AFE3	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	4-coumarate--CoA ligase-like 7.	0.883
CCOAOMT6	LOC107798422	Q42945	A0A1S4AJS0	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	4-coumarate--CoA ligase-like 7.	0.883
CCOAOMT6	LOC107801774	Q42945	Q93XP8	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	Chalcone synthase 1B-like; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.	0.797
CCOAOMT6	LOC107802063	Q42945	A0A1S4AWI6	Caffeoyl-CoA O-methyltransferase 6; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers. Methylates almost exclusively caffeoyl-CoA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.	Phenylalanine ammonia-lyase.	0.628