(35 nodes) (2018) Synthetic Enzymology and the Fountain of Youth: Repurposing Biology for Longevity. network (Nicotiana tabacum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	LOC107761111	4-coumarate--CoA ligase 2-like. (546 aa)
	LOC107761482	Phenylalanine ammonia-lyase. (715 aa)
	LOC107766072	4-coumarate--CoA ligase 2-like. (542 aa)
	LOC107767884	4-coumarate--CoA ligase 2-like. (549 aa)
	LOC107769758	4-coumarate--CoA ligase 2-like. (571 aa)
	LOC107785405	4-coumarate--CoA ligase 1-like. (547 aa)
	LOC107786762	Phenylalanine ammonia-lyase. (712 aa)
	LOC107787414	4-coumarate--CoA ligase-like 9. (549 aa)
	LOC107790326	4-coumarate--CoA ligase-like 9. (549 aa)
	LOC107792668	Phenylalanine ammonia-lyase. (712 aa)
	LOC107793030	4-coumarate--CoA ligase-like 6. (565 aa)
	LOC107797035	4-coumarate--CoA ligase-like 7. (538 aa)
	LOC107798422	4-coumarate--CoA ligase-like 7. (538 aa)
	LOC107801263	Chalcone synthase G-like; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (431 aa)
	LOC107802063	Phenylalanine ammonia-lyase. (717 aa)
	LOC107803673	4-coumarate--CoA ligase 1. (547 aa)
	LOC107803813	4-coumarate--CoA ligase-like 1. (551 aa)
	LOC107803965	4-coumarate--CoA ligase 2-like. (447 aa)
	LOC107809744	Chalcone synthase 2; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (389 aa)
	LOC107810554	4-coumarate--CoA ligase 2-like. (558 aa)
	LOC107813425	Chalcone synthase J-like isoform X1; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (390 aa)
	LOC107813613	Chalcone synthase A; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (389 aa)
	LOC107814113	4-coumarate--CoA ligase-like 1. (551 aa)
	LOC107820497	Phenylalanine ammonia-lyase. (717 aa)
	LOC107826422	Chalcone synthase 2-like; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (389 aa)
	LOC107826655	4-coumarate--CoA ligase-like 6 isoform X1. (565 aa)
	LOC107831213	Phenylalanine ammonia-lyase. (719 aa)
	LOC107831218	4-coumarate--CoA ligase 2-like. (569 aa)
	LOC107832236	Chalcone synthase G-like; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (390 aa)
	pal4	Phenylalanine ammonia-lyase. (717 aa)
	4CL2	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family. (542 aa)
	TPA1	Phenylalanine ammonia-lyase; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family. (715 aa)
	PALA	Phenylalanine ammonia-lyase; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton. (712 aa)
	NtPAL	Phenylalanine ammonia-lyase; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family. (712 aa)
	LOC107801774	Chalcone synthase 1B-like; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (389 aa)

Your Current Organism:

Nicotiana tabacum

NCBI taxonomy Id: 4097
Other names: American tobacco, N. tabacum, Nicotiana tabacum L., common tobacco, tobacco

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
4CL2	LOC107761482	O24146	A0A1S3X5R5	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Phenylalanine ammonia-lyase.	0.917
4CL2	LOC107786762	O24146	A0A1S3ZH48	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Phenylalanine ammonia-lyase.	0.786
4CL2	LOC107792668	O24146	A0A1S4A1B2	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Phenylalanine ammonia-lyase.	0.786
4CL2	LOC107801263	O24146	A0A1S4ATN2	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Chalcone synthase G-like; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.	0.902
4CL2	LOC107801774	O24146	Q93XP8	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Chalcone synthase 1B-like; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.	0.902
4CL2	LOC107802063	O24146	A0A1S4AWI6	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Phenylalanine ammonia-lyase.	0.913
4CL2	LOC107809744	O24146	A0A1S4BM26	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Chalcone synthase 2; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.	0.902
4CL2	LOC107813425	O24146	A0A1S4BZ53	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Chalcone synthase J-like isoform X1; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.	0.902
4CL2	LOC107813613	O24146	A0A1S4C003	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Chalcone synthase A; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.	0.902
4CL2	LOC107820497	O24146	A0A1S4CMI5	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Phenylalanine ammonia-lyase.	0.913
4CL2	LOC107826422	O24146	A0A1S4D630	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Chalcone synthase 2-like; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.	0.902
4CL2	LOC107831213	O24146	A0A1S4DM00	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Phenylalanine ammonia-lyase.	0.929
4CL2	LOC107832236	O24146	A0A1S4DQY3	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Chalcone synthase G-like; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.	0.902
4CL2	NtPAL	O24146	P45733	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Phenylalanine ammonia-lyase; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family.	0.933
4CL2	PALA	O24146	P35513	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Phenylalanine ammonia-lyase; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.	0.922
4CL2	TPA1	O24146	P25872	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Phenylalanine ammonia-lyase; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family.	0.775
4CL2	pal4	O24146	C6ZIA5	4-coumarate--CoA ligase 2; Belongs to the ATP-dependent AMP-binding enzyme family.	Phenylalanine ammonia-lyase.	0.929
LOC107761111	LOC107761482	A0A1S3X4W9	A0A1S3X5R5	4-coumarate--CoA ligase 2-like.	Phenylalanine ammonia-lyase.	0.929
LOC107761111	LOC107786762	A0A1S3X4W9	A0A1S3ZH48	4-coumarate--CoA ligase 2-like.	Phenylalanine ammonia-lyase.	0.817
LOC107761111	LOC107792668	A0A1S3X4W9	A0A1S4A1B2	4-coumarate--CoA ligase 2-like.	Phenylalanine ammonia-lyase.	0.817