(16 nodes) Helix-hairpin-helix DNA-binding motif class 1 network (Nicotiana tabacum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	LOC107760687	N-glycosylase/DNA lyase OGG1. (391 aa)
	LOC107762504	Kinesin-like protein KIF22 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (674 aa)
	LOC107775656	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily. (343 aa)
	LOC107776580	DNA excision repair protein ERCC-1-like. (399 aa)
	LOC107780148	Uncharacterized protein LOC107780148. (215 aa)
	LOC107798302	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (378 aa)
	LOC107809984	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (622 aa)
	LOC107812292	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (620 aa)
	LOC107814431	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (379 aa)
	LOC107830439	Crossover junction endonuclease MUS81-like. (657 aa)
	LOC107796476	DExH-box ATP-dependent RNA helicase DExH17-like isoform X1. (1225 aa)
	LOC107832591	Uncharacterized protein LOC107832591. (215 aa)
	LOC107791766	Crossover junction endonuclease MUS81-like. (657 aa)
	LOC107789756	Uncharacterized protein LOC107789756. (207 aa)
	LOC107787358	DNA excision repair protein ERCC-1-like. (393 aa)
	LOC107781635	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily. (343 aa)

Your Current Organism:

Nicotiana tabacum

NCBI taxonomy Id: 4097
Other names: American tobacco, N. tabacum, Nicotiana tabacum L., common tobacco, tobacco

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107760687	LOC107776580	A0A1S3X2V4	A0A1S3YIC2	N-glycosylase/DNA lyase OGG1.	DNA excision repair protein ERCC-1-like.	0.546
LOC107760687	LOC107787358	A0A1S3X2V4	A0A1S3ZIU6	N-glycosylase/DNA lyase OGG1.	DNA excision repair protein ERCC-1-like.	0.546
LOC107760687	LOC107798302	A0A1S3X2V4	A0A1S4AJD0	N-glycosylase/DNA lyase OGG1.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.550
LOC107760687	LOC107814431	A0A1S3X2V4	A0A1S4C2P0	N-glycosylase/DNA lyase OGG1.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.550
LOC107762504	LOC107809984	A0A1S3X8L1	A0A1S4BMR9	Kinesin-like protein KIF22 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.689
LOC107762504	LOC107812292	A0A1S3X8L1	A0A1S4BVC6	Kinesin-like protein KIF22 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.689
LOC107775656	LOC107776580	A0A1S3YFL3	A0A1S3YIC2	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily.	DNA excision repair protein ERCC-1-like.	0.550
LOC107775656	LOC107781635	A0A1S3YFL3	A0A1S3Z089	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily.	0.900
LOC107775656	LOC107787358	A0A1S3YFL3	A0A1S3ZIU6	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily.	DNA excision repair protein ERCC-1-like.	0.550
LOC107775656	LOC107791766	A0A1S3YFL3	A0A1S3ZYF4	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily.	Crossover junction endonuclease MUS81-like.	0.813
LOC107775656	LOC107796476	A0A1S3YFL3	A0A1S4ADN5	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily.	DExH-box ATP-dependent RNA helicase DExH17-like isoform X1.	0.511
LOC107775656	LOC107830439	A0A1S3YFL3	A0A1S4DJ93	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily.	Crossover junction endonuclease MUS81-like.	0.813
LOC107776580	LOC107760687	A0A1S3YIC2	A0A1S3X2V4	DNA excision repair protein ERCC-1-like.	N-glycosylase/DNA lyase OGG1.	0.546
LOC107776580	LOC107775656	A0A1S3YIC2	A0A1S3YFL3	DNA excision repair protein ERCC-1-like.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily.	0.550
LOC107776580	LOC107781635	A0A1S3YIC2	A0A1S3Z089	DNA excision repair protein ERCC-1-like.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA. Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination; Belongs to the RecA family. RAD51 subfamily.	0.550
LOC107776580	LOC107787358	A0A1S3YIC2	A0A1S3ZIU6	DNA excision repair protein ERCC-1-like.	DNA excision repair protein ERCC-1-like.	0.900
LOC107776580	LOC107791766	A0A1S3YIC2	A0A1S3ZYF4	DNA excision repair protein ERCC-1-like.	Crossover junction endonuclease MUS81-like.	0.982
LOC107776580	LOC107798302	A0A1S3YIC2	A0A1S4AJD0	DNA excision repair protein ERCC-1-like.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.522
LOC107776580	LOC107814431	A0A1S3YIC2	A0A1S4C2P0	DNA excision repair protein ERCC-1-like.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.522
LOC107776580	LOC107830439	A0A1S3YIC2	A0A1S4DJ93	DNA excision repair protein ERCC-1-like.	Crossover junction endonuclease MUS81-like.	0.982