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| | ENSPMGP00000000027 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa) |
| | ENSPMGP00000000209 | Cell division cycle associated 7a. (399 aa) |
| | ENSPMGP00000000505 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (537 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (587 aa) |
| | ENSPMGP00000001324 | ORC_WH_C domain-containing protein. (694 aa) |
| | ENSPMGP00000001519 | DNA replication helicase/nuclease 2. (918 aa) |
| | ENSPMGP00000001669 | LisH domain-containing protein. (388 aa) |
| | ENSPMGP00000001795 | XPGN domain-containing protein. (308 aa) |
| | ENSPMGP00000001821 | XPGI domain-containing protein. (369 aa) |
| | ENSPMGP00000001872 | Poly (ADP-ribose) glycohydrolase a. (626 aa) |
| | ENSPMGP00000002035 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1348 aa) |
| | ENSPMGP00000002102 | Piezo_RRas_bdg domain-containing protein. (601 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (630 aa) |
| | ENSPMGP00000002437 | Uncharacterized protein. (283 aa) |
| | ENSPMGP00000002554 | Origin recognition complex, subunit 5. (413 aa) |
| | ENSPMGP00000002767 | Dpoe2NT domain-containing protein. (92 aa) |
| | ENSPMGP00000002778 | DNA helicase; Belongs to the MCM family. (809 aa) |
| | ENSPMGP00000002787 | Polymerase (DNA directed), epsilon 2. (325 aa) |
| | ENSPMGP00000002793 | Poly [ADP-ribose] polymerase. (624 aa) |
| | ENSPMGP00000002851 | Uncharacterized protein. (291 aa) |
| | ENSPMGP00000003200 | Xeroderma pigmentosum, complementation group A. (268 aa) |
| | ENSPMGP00000003418 | RAD51 paralog C. (345 aa) |
| | ENSPMGP00000003948 | MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). (943 aa) |
| | ENSPMGP00000003957 | Replication factor C (activator 1) 2. (342 aa) |
| | ENSPMGP00000003968 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (248 aa) |
| | ENSPMGP00000004022 | MutS homolog 2 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). (793 aa) |
| | ENSPMGP00000004039 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (559 aa) |
| | ENSPMGP00000004107 | Thymine DNA glycosylase, tandem duplicate 1. (379 aa) |
| | ENSPMGP00000004216 | Thymine DNA glycosylase, tandem duplicate 1. (356 aa) |
| | ENSPMGP00000004456 | MutL_C domain-containing protein. (191 aa) |
| | ENSPMGP00000004460 | Uncharacterized protein. (229 aa) |
| | ENSPMGP00000004508 | RAD9 checkpoint clamp component B. (183 aa) |
| | ENSPMGP00000004977 | N-methylpurine DNA glycosylase. (283 aa) |
| | ENSPMGP00000005307 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa) |
| | ENSPMGP00000005322 | Uncharacterized protein. (141 aa) |
| | ENSPMGP00000005337 | Replication protein A2. (280 aa) |
| | ENSPMGP00000005554 | RecQ mediated genome instability 2. (149 aa) |
| | ENSPMGP00000005772 | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (611 aa) |
| | ENSPMGP00000006344 | Poly [ADP-ribose] polymerase. (532 aa) |
| | PIEZO2 | Piezo type mechanosensitive ion channel component 2. (1383 aa) |
| | ENSPMGP00000006737 | RAD17 checkpoint clamp loader component. (472 aa) |
| | ENSPMGP00000007078 | Polymerase (DNA directed), eta. (694 aa) |
| | ENSPMGP00000007240 | Chromatin licensing and DNA replication factor 1. (653 aa) |
| | ENSPMGP00000007337 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (975 aa) |
| | ENSPMGP00000007564 | Interferon induced with helicase C domain 1. (949 aa) |
| | ENSPMGP00000007586 | Mitotic arrest deficient 2 like 2. (205 aa) |
| | ENSPMGP00000007885 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa) |
| | ENSPMGP00000008012 | Polymerase (DNA directed) iota. (654 aa) |
| | ENSPMGP00000008014 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (896 aa) |
| | ENSPMGP00000008322 | DNA_pol_B domain-containing protein. (367 aa) |
| | ENSPMGP00000008407 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (562 aa) |
| | ENSPMGP00000008465 | Uncharacterized protein. (364 aa) |
| | ENSPMGP00000008469 | F-box domain-containing protein. (57 aa) |
| | ENSPMGP00000008765 | Poly [ADP-ribose] polymerase. (1455 aa) |
| | ENSPMGP00000009018 | Nei-like DNA glycosylase 1. (397 aa) |
| | ENSPMGP00000009464 | GINS complex subunit 1 (Psf1 homolog). (196 aa) |
| | ENSPMGP00000009518 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11. (829 aa) |
| | ENSPMGP00000009758 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (717 aa) |
| | ENSPMGP00000010071 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (454 aa) |
| | ENSPMGP00000010266 | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (472 aa) |
| | ENSPMGP00000010348 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (495 aa) |
| | ENSPMGP00000010440 | Cell cycle checkpoint control protein; Belongs to the rad9 family. (385 aa) |
| | ENSPMGP00000010557 | Methionine sulfoxide reductase B1b. (383 aa) |
| | ENSPMGP00000010788 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (975 aa) |
| | ENSPMGP00000010861 | Minichromosome maintenance complex binding protein. (628 aa) |
| | ENSPMGP00000011036 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (549 aa) |
| | ENSPMGP00000011077 | Uncharacterized protein. (133 aa) |
| | ENSPMGP00000011542 | ATPase_AAA_core domain-containing protein. (799 aa) |
| | ENSPMGP00000011645 | MRE11 homolog A, double strand break repair nuclease. (451 aa) |
| | ENSPMGP00000011646 | Metallophos domain-containing protein. (104 aa) |
| | ENSPMGP00000011905 | RING-type domain-containing protein. (103 aa) |
| | ENSPMGP00000012216 | Endo/exonuclease/phosphatase domain-containing protein. (341 aa) |
| | ENSPMGP00000012423 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (405 aa) |
| | ENSPMGP00000012544 | BRCT domain-containing protein. (357 aa) |
| | ENSPMGP00000013042 | DEXH (Asp-Glu-X-His) box polypeptide 58. (672 aa) |
| | ENSPMGP00000013444 | Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (497 aa) |
| | ENSPMGP00000013512 | DNA topoisomerase II binding protein 1. (1436 aa) |
| | ENSPMGP00000013670 | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (497 aa) |
| | ENSPMGP00000013690 | BRCT domain-containing protein. (564 aa) |
| | ENSPMGP00000013931 | Uncharacterized protein. (188 aa) |
| | ENSPMGP00000013932 | Uncharacterized protein. (126 aa) |
| | ENSPMGP00000014113 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (568 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (275 aa) |
| | ENSPMGP00000014735 | TEN1 subunit of CST complex. (133 aa) |
| | ENSPMGP00000015062 | Uncharacterized protein. (260 aa) |
| | ENSPMGP00000015067 | HMG box domain-containing protein. (551 aa) |
| | ENSPMGP00000015194 | RECA_2 domain-containing protein. (359 aa) |
| | ENSPMGP00000015520 | BRCT domain-containing protein. (144 aa) |
| | ENSPMGP00000015622 | 8-oxoguanine DNA glycosylase. (383 aa) |
| | ENSPMGP00000015810 | Uncharacterized protein. (322 aa) |
| | ENSPMGP00000015885 | DNA polymerase. (1380 aa) |
| | ENSPMGP00000016417 | DNA ligase. (913 aa) |
| | ENSPMGP00000016432 | Piezo_RRas_bdg domain-containing protein. (307 aa) |
| | ENSPMGP00000016439 | Piezo-type mechanosensitive ion channel component 1. (1194 aa) |
| | ENSPMGP00000016508 | Uncharacterized protein. (167 aa) |
| | ENSPMGP00000016599 | BRCT domain-containing protein. (176 aa) |
| | ENSPMGP00000016603 | ANK_REP_REGION domain-containing protein. (261 aa) |
| | ENSPMGP00000016642 | Zgc:110269. (304 aa) |
| | ENSPMGP00000016778 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (246 aa) |
| | ENSPMGP00000016780 | BRCA1 interacting protein C-terminal helicase 1. (864 aa) |
| | ENSPMGP00000016967 | Ankyrin repeat domain 11. (2717 aa) |
| | ENSPMGP00000017107 | STN1 subunit of CST complex. (346 aa) |
| | ENSPMGP00000017260 | Basic, immunoglobulin-like variable motif containing. (378 aa) |
| | ENSPMGP00000017380 | X-ray repair complementing defective repair in Chinese hamster cells 6. (590 aa) |
| | ENSPMGP00000017444 | Piezo_RRas_bdg domain-containing protein. (599 aa) |
| | ENSPMGP00000017525 | Zgc:77287. (421 aa) |
| | ENSPMGP00000017984 | Helicase, lymphoid specific. (780 aa) |
| | ENSPMGP00000018017 | Uncharacterized protein. (303 aa) |
| | ENSPMGP00000018021 | Von Willebrand factor A domain containing 5B2. (976 aa) |
| | ENSPMGP00000018175 | Uncharacterized protein. (405 aa) |
| | ENSPMGP00000018509 | Piezo_RRas_bdg domain-containing protein. (537 aa) |
| | ENSPMGP00000018529 | Replication factor C (activator 1) 5. (336 aa) |
| | ENSPMGP00000018587 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (885 aa) |
| | ENSPMGP00000018656 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (144 aa) |
| | ENSPMGP00000018715 | Checkpoint kinase 2. (476 aa) |
| | ENSPMGP00000018716 | Tudor domain containing 3. (757 aa) |
| | ENSPMGP00000018940 | Helicase ATP-binding domain-containing protein. (107 aa) |
| | ENSPMGP00000019186 | DNA polymerase. (1034 aa) |
| | ENSPMGP00000019213 | O-6-methylguanine-DNA methyltransferase. (185 aa) |
| | ENSPMGP00000019369 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2737 aa) |
| | ENSPMGP00000019587 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2554 aa) |
| | ENSPMGP00000019989 | DNA helicase; Belongs to the MCM family. (809 aa) |
| | ENSPMGP00000020239 | Small nuclear ribonucleoprotein-associated protein. (233 aa) |
| | ENSPMGP00000020304 | CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae). (776 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (336 aa) |
| | ENSPMGP00000020400 | Replication factor C (activator 1) 4. (358 aa) |
| | ENSPMGP00000020510 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (865 aa) |
| | ENSPMGP00000020518 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (333 aa) |
| | ENSPMGP00000021448 | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (476 aa) |
| | ENSPMGP00000021513 | Zf-primase domain-containing protein. (206 aa) |
| | ENSPMGP00000021917 | TOX high mobility group box family member 2. (428 aa) |
| | ENSPMGP00000021944 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (929 aa) |
| | ENSPMGP00000022767 | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (202 aa) |
| | ENSPMGP00000022771 | DNA_pol_B_thumb domain-containing protein. (54 aa) |
| | ENSPMGP00000022773 | Enkurin domain-containing protein. (303 aa) |
| | ENSPMGP00000022902 | DNA helicase; Belongs to the MCM family. (694 aa) |
| | ENSPMGP00000022927 | RECA_2 domain-containing protein. (312 aa) |
| | ENSPMGP00000022931 | DNA ligase. (895 aa) |
| | ENSPMGP00000023052 | Aprataxin. (343 aa) |
| | ENSPMGP00000023182 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | ENSPMGP00000023356 | HATPase_c domain-containing protein. (132 aa) |
| | ENSPMGP00000023358 | Uncharacterized protein. (134 aa) |
| | ENSPMGP00000023441 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (310 aa) |
| | ENSPMGP00000023442 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (328 aa) |
| | ENSPMGP00000023519 | Uncharacterized protein. (465 aa) |
| | ENSPMGP00000023767 | Uncharacterized protein. (216 aa) |
| | ENSPMGP00000024084 | Exonuclease 1. (559 aa) |
| | ENSPMGP00000024137 | Uncharacterized protein. (114 aa) |
| | ENSPMGP00000024148 | RAD50 homolog, double strand break repair protein. (1270 aa) |
| | ENSPMGP00000024284 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (722 aa) |
| | ENSPMGP00000024769 | WD repeat and HMG-box DNA binding protein 1. (1043 aa) |
| | ENSPMGP00000024912 | Timeless circadian clock. (1215 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa) |
| | ENSPMGP00000025147 | DNA helicase; Belongs to the MCM family. (791 aa) |
| | ENSPMGP00000025178 | Excision repair cross-complementation group 6. (1334 aa) |
| | ENSPMGP00000025186 | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (2516 aa) |
| | ENSPMGP00000025557 | Origin recognition complex, subunit 2. (360 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa) |
| | ENSPMGP00000025960 | MutS homolog 5. (674 aa) |
| | ENSPMGP00000026065 | X-ray repair complementing defective repair in Chinese hamster cells 1. (567 aa) |
| | ENSPMGP00000026072 | Exonuclease 3'-5' domain containing 2. (626 aa) |
| | ENSPMGP00000026390 | DNA helicase; Belongs to the MCM family. (890 aa) |
| | ENSPMGP00000026408 | Replication protein A3. (122 aa) |
| | ENSPMGP00000026459 | X-ray repair complementing defective repair in Chinese hamster cells 4. (318 aa) |
| | ENSPMGP00000026467 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (798 aa) |
| | ENSPMGP00000026544 | RecQ helicase-like 4. (1317 aa) |
| | ENSPMGP00000026605 | DBF4 zinc finger. (529 aa) |
| | ENSPMGP00000026818 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa) |
| | ENSPMGP00000027071 | RECA_2 domain-containing protein. (318 aa) |
| | ENSPMGP00000027424 | MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (707 aa) |
| | ENSPMGP00000027426 | Si:ch211-141o9.10. (343 aa) |
| | ENSPMGP00000027443 | Polymerase (DNA directed) kappa. (419 aa) |
| | ENSPMGP00000027525 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (131 aa) |
| | ENSPMGP00000027527 | SCY domain-containing protein. (116 aa) |
| | ENSPMGP00000027563 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (327 aa) |
| | ENSPMGP00000027589 | RAD52 homolog, DNA repair protein. (390 aa) |
| | ENSPMGP00000027624 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (320 aa) |
| | ENSPMGP00000027896 | Si:dkey-28b4.7. (119 aa) |
| | ENSPMGP00000027920 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (304 aa) |
| | ENSPMGP00000027942 | Uncharacterized protein. (762 aa) |
| | ENSPMGP00000028030 | BRCT domain-containing protein. (221 aa) |
| | ENSPMGP00000028142 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (412 aa) |
| | ENSPMGP00000028190 | Geminin DNA replication inhibitor. (232 aa) |
| | ENSPMGP00000028205 | DNA replication and sister chromatid cohesion 1. (380 aa) |
| | ENSPMGP00000028425 | Uncharacterized protein. (725 aa) |
| | ENSPMGP00000028552 | RAD1 homolog (S. pombe). (281 aa) |
| | ENSPMGP00000028598 | Polymerase (DNA directed), delta 2, regulatory subunit. (446 aa) |
| | ENSPMGP00000028678 | BRCT domain-containing protein. (508 aa) |
| | ENSPMGP00000028766 | Tyrosyl-DNA phosphodiesterase 1. (586 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1105 aa) |
| | ENSPMGP00000029368 | Replication factor C (activator 1) 3. (270 aa) |
| | ENSPMGP00000029520 | PIEZO domain-containing protein. (492 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (654 aa) |
| | ENSPMGP00000029656 | Uncharacterized protein. (279 aa) |
| | ENSPMGP00000029829 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (126 aa) |
| | ENSPMGP00000030014 | BRCT domain-containing protein. (398 aa) |
| | ENSPMGP00000030015 | RFC1 domain-containing protein. (135 aa) |
| | ENSPMGP00000030053 | Histone PARylation factor 1. (335 aa) |
