(38 nodes) Mixed, incl. Protein neddylation, and SCF-dependent proteasomal ubiquitin-dependent protein catabolic process network (Periophthalmus magnuspinnatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPMGP00000000873	Si:dkey-192l18.9. (468 aa)
	ENSPMGP00000001316	Uncharacterized protein. (545 aa)
	ENSPMGP00000002036	UBR-type domain-containing protein. (81 aa)
	ENSPMGP00000002040	Uncharacterized protein. (363 aa)
	ENSPMGP00000002847	DCN1-like protein. (258 aa)
	ENSPMGP00000003107	Uncharacterized protein. (276 aa)
	ENSPMGP00000003515	WD_REPEATS_REGION domain-containing protein. (774 aa)
	ENSPMGP00000004927	Uncharacterized protein. (236 aa)
	ENSPMGP00000005148	DCN1-like protein. (327 aa)
	ENSPMGP00000006841	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (397 aa)
	ENSPMGP00000006881	F-box and WD repeat domain containing 2. (389 aa)
	ENSPMGP00000009851	Cullin 1b; Belongs to the cullin family. (776 aa)
	ENSPMGP00000009914	Tripartite motif containing 16. (611 aa)
	ENSPMGP00000010125	F-box protein 4. (399 aa)
	ENSPMGP00000010394	Lysine (K)-specific demethylase 2Ab. (827 aa)
	ENSPMGP00000010839	CDK2 associated cullin domain 1; Belongs to the cullin family. (224 aa)
	ENSPMGP00000012043	F-box and leucine-rich repeat protein 14a. (400 aa)
	ENSPMGP00000012948	DCN1-like protein. (178 aa)
	ENSPMGP00000014014	Uncharacterized protein. (80 aa)
	ENSPMGP00000015149	Uncharacterized protein. (838 aa)
	ENSPMGP00000017027	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (505 aa)
	ENSPMGP00000018230	Ubiquitin-conjugating enzyme E2F (putative); Belongs to the ubiquitin-conjugating enzyme family. (135 aa)
	ENSPMGP00000018582	Zgc:175088. (160 aa)
	ENSPMGP00000018811	TIP120 domain-containing protein. (1235 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (436 aa)
	ENSPMGP00000020298	Uncharacterized protein. (65 aa)
	ENSPMGP00000020299	Uncharacterized protein. (62 aa)
	ENSPMGP00000020407	F-box and WD repeat domain containing 7. (546 aa)
	ENSPMGP00000021707	Fem-1 homolog c (C. elegans). (618 aa)
	ENSPMGP00000022075	Ring-box 1, E3 ubiquitin protein ligase. (125 aa)
	UBE2M	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (172 aa)
	ENSPMGP00000023163	Ubiquitin-like domain-containing protein. (94 aa)
	ENSPMGP00000023295	Ubiquitin-like domain-containing protein. (90 aa)
	ENSPMGP00000023701	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
	ENSPMGP00000025695	DCN1-like protein. (220 aa)
	ENSPMGP00000026952	Uncharacterized protein. (115 aa)
	ENSPMGP00000028365	F-box and WD repeat domain containing 9. (404 aa)
	ENSPMGP00000028715	F-box protein 9. (384 aa)

Your Current Organism:

Periophthalmus magnuspinnatus

NCBI taxonomy Id: 409849
Other names: P. magnuspinnatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPMGP00000000873	ENSPMGP00000001316	ENSPMGP00000000873	ENSPMGP00000001316	Si:dkey-192l18.9.	Uncharacterized protein.	0.608
ENSPMGP00000000873	ENSPMGP00000003515	ENSPMGP00000000873	ENSPMGP00000003515	Si:dkey-192l18.9.	WD_REPEATS_REGION domain-containing protein.	0.608
ENSPMGP00000000873	ENSPMGP00000006841	ENSPMGP00000000873	ENSPMGP00000006841	Si:dkey-192l18.9.	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase.	0.563
ENSPMGP00000000873	ENSPMGP00000009851	ENSPMGP00000000873	ENSPMGP00000009851	Si:dkey-192l18.9.	Cullin 1b; Belongs to the cullin family.	0.901
ENSPMGP00000000873	ENSPMGP00000009914	ENSPMGP00000000873	ENSPMGP00000009914	Si:dkey-192l18.9.	Tripartite motif containing 16.	0.608
ENSPMGP00000000873	ENSPMGP00000010839	ENSPMGP00000000873	ENSPMGP00000010839	Si:dkey-192l18.9.	CDK2 associated cullin domain 1; Belongs to the cullin family.	0.728
ENSPMGP00000000873	ENSPMGP00000017027	ENSPMGP00000000873	ENSPMGP00000017027	Si:dkey-192l18.9.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.662
ENSPMGP00000000873	ENSPMGP00000018230	ENSPMGP00000000873	ENSPMGP00000018230	Si:dkey-192l18.9.	Ubiquitin-conjugating enzyme E2F (putative); Belongs to the ubiquitin-conjugating enzyme family.	0.669
ENSPMGP00000000873	ENSPMGP00000018811	ENSPMGP00000000873	ENSPMGP00000018811	Si:dkey-192l18.9.	TIP120 domain-containing protein.	0.670
ENSPMGP00000000873	ENSPMGP00000020298	ENSPMGP00000000873	ENSPMGP00000020298	Si:dkey-192l18.9.	Uncharacterized protein.	0.670
ENSPMGP00000000873	ENSPMGP00000020299	ENSPMGP00000000873	ENSPMGP00000020299	Si:dkey-192l18.9.	Uncharacterized protein.	0.670
ENSPMGP00000000873	ENSPMGP00000020407	ENSPMGP00000000873	ENSPMGP00000020407	Si:dkey-192l18.9.	F-box and WD repeat domain containing 7.	0.608
ENSPMGP00000000873	ENSPMGP00000022075	ENSPMGP00000000873	ENSPMGP00000022075	Si:dkey-192l18.9.	Ring-box 1, E3 ubiquitin protein ligase.	0.900
ENSPMGP00000000873	ENSPMGP00000023163	ENSPMGP00000000873	ENSPMGP00000023163	Si:dkey-192l18.9.	Ubiquitin-like domain-containing protein.	0.609
ENSPMGP00000000873	ENSPMGP00000023295	ENSPMGP00000000873	ENSPMGP00000023295	Si:dkey-192l18.9.	Ubiquitin-like domain-containing protein.	0.779
ENSPMGP00000000873	ENSPMGP00000023701	ENSPMGP00000000873	ENSPMGP00000023701	Si:dkey-192l18.9.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.944
ENSPMGP00000000873	ENSPMGP00000026952	ENSPMGP00000000873	ENSPMGP00000026952	Si:dkey-192l18.9.	Uncharacterized protein.	0.584
ENSPMGP00000000873	ENSPMGP00000028365	ENSPMGP00000000873	ENSPMGP00000028365	Si:dkey-192l18.9.	F-box and WD repeat domain containing 9.	0.608
ENSPMGP00000000873	ENSPMGP00000028715	ENSPMGP00000000873	ENSPMGP00000028715	Si:dkey-192l18.9.	F-box protein 9.	0.504
ENSPMGP00000000873	UBA3	ENSPMGP00000000873	ENSPMGP00000019145	Si:dkey-192l18.9.	Ubiquitin like modifier activating enzyme 3.	0.662