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| | ENSPMGP00000007240 | Chromatin licensing and DNA replication factor 1. (653 aa) |
| | ENSPMGP00000000027 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa) |
| | ENSPMGP00000000182 | Single-stranded DNA binding protein 1. (148 aa) |
| | ENSPMGP00000000505 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (537 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (587 aa) |
| | ENSPMGP00000000691 | Kin17 DNA and RNA binding protein. (384 aa) |
| | ENSPMGP00000000772 | GUCT domain-containing protein. (138 aa) |
| | ENSPMGP00000000792 | DEAD (Asp-Glu-Ala-Asp) box helicase 21. (352 aa) |
| | ENSPMGP00000000850 | SPT16 homolog, facilitates chromatin remodeling subunit. (1035 aa) |
| | ENSPMGP00000001324 | ORC_WH_C domain-containing protein. (694 aa) |
| | ENSPMGP00000001519 | DNA replication helicase/nuclease 2. (918 aa) |
| | ENSPMGP00000001692 | WD repeat domain 18. (429 aa) |
| | ENSPMGP00000001855 | HD domain-containing protein. (556 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (630 aa) |
| | ENSPMGP00000002554 | Origin recognition complex, subunit 5. (413 aa) |
| | ENSPMGP00000002767 | Dpoe2NT domain-containing protein. (92 aa) |
| | ENSPMGP00000002778 | DNA helicase; Belongs to the MCM family. (809 aa) |
| | ENSPMGP00000002787 | Polymerase (DNA directed), epsilon 2. (325 aa) |
| | ENSPMGP00000003171 | RIBORED_LARGE domain-containing protein. (83 aa) |
| | ENSPMGP00000030032 | POLAc domain-containing protein. (623 aa) |
| | ENSPMGP00000030031 | Uncharacterized protein. (109 aa) |
| | ENSPMGP00000030030 | DEAD domain-containing protein. (168 aa) |
| | ENSPMGP00000030015 | RFC1 domain-containing protein. (135 aa) |
| | ENSPMGP00000030014 | BRCT domain-containing protein. (398 aa) |
| | ENSPMGP00000029992 | Leucine-rich repeats and WD repeat domain containing 1. (707 aa) |
| | ENSPMGP00000029829 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (126 aa) |
| | ENSPMGP00000029620 | Nurim. (264 aa) |
| | ENSPMGP00000029368 | Replication factor C (activator 1) 3. (270 aa) |
| | ENSPMGP00000029337 | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (473 aa) |
| | ENSPMGP00000029070 | TatD DNase domain containing 1. (298 aa) |
| | ENSPMGP00000029058 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (252 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1105 aa) |
| | ENSPMGP00000028797 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (583 aa) |
| | ENSPMGP00000028598 | Polymerase (DNA directed), delta 2, regulatory subunit. (446 aa) |
| | ENSPMGP00000028514 | Ribonucleotide reductase M2 b. (294 aa) |
| | ENSPMGP00000028425 | Uncharacterized protein. (725 aa) |
| | ENSPMGP00000028311 | Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (528 aa) |
| | ENSPMGP00000028223 | Ring finger and WD repeat domain 3. (514 aa) |
| | ENSPMGP00000028205 | DNA replication and sister chromatid cohesion 1. (380 aa) |
| | ENSPMGP00000028190 | Geminin DNA replication inhibitor. (232 aa) |
| | ENSPMGP00000028142 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (412 aa) |
| | ENSPMGP00000028109 | WD_REPEATS_REGION domain-containing protein. (623 aa) |
| | ENSPMGP00000027896 | Si:dkey-28b4.7. (119 aa) |
| | ENSPMGP00000027850 | Uncharacterized protein. (292 aa) |
| | ENSPMGP00000027809 | Ribonucleotide reductase M2 polypeptide. (355 aa) |
| | ENSPMGP00000027527 | SCY domain-containing protein. (116 aa) |
| | ENSPMGP00000027525 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (131 aa) |
| | ENSPMGP00000027443 | Polymerase (DNA directed) kappa. (419 aa) |
| | ENSPMGP00000027407 | MMS22-like, DNA repair protein. (1226 aa) |
| | ENSPMGP00000026818 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa) |
| | ENSPMGP00000026544 | RecQ helicase-like 4. (1317 aa) |
| | ENSPMGP00000026513 | TPR_REGION domain-containing protein. (266 aa) |
| | ENSPMGP00000026467 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (798 aa) |
| | ENSPMGP00000026408 | Replication protein A3. (122 aa) |
| | ENSPMGP00000026390 | DNA helicase; Belongs to the MCM family. (890 aa) |
| | ENSPMGP00000026254 | TRAF-interacting protein. (439 aa) |
| | ENSPMGP00000026072 | Exonuclease 3'-5' domain containing 2. (626 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Belongs to the MGME1 family. (361 aa) |
| | ENSPMGP00000025557 | Origin recognition complex, subunit 2. (360 aa) |
| | ENSPMGP00000025147 | DNA helicase; Belongs to the MCM family. (791 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa) |
| | ENSPMGP00000024912 | Timeless circadian clock. (1215 aa) |
| | ENSPMGP00000024769 | WD repeat and HMG-box DNA binding protein 1. (1043 aa) |
| | ENSPMGP00000013369 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (650 aa) |
| | ENSPMGP00000013132 | Helicase ATP-binding domain-containing protein. (249 aa) |
| | ENSPMGP00000013130 | Uncharacterized protein. (422 aa) |
| | ENSPMGP00000012993 | Tonsoku-like, DNA repair protein. (1226 aa) |
| | NFIX | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (459 aa) |
| | ENSPMGP00000012423 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (405 aa) |
| | ENSPMGP00000012419 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Belongs to the DEAD box helicase family. (771 aa) |
| | ENSPMGP00000012064 | Inhibitor of growth protein. (234 aa) |
| | ENSPMGP00000011789 | Chromatin assembly factor 1, subunit B. (566 aa) |
| | ENSPMGP00000011677 | Uncharacterized protein. (151 aa) |
| | ENSPMGP00000011646 | Metallophos domain-containing protein. (104 aa) |
| | ENSPMGP00000011645 | MRE11 homolog A, double strand break repair nuclease. (451 aa) |
| | ENSPMGP00000011542 | ATPase_AAA_core domain-containing protein. (799 aa) |
| | ENSPMGP00000011247 | Uncharacterized protein. (510 aa) |
| | ENSPMGP00000011077 | Uncharacterized protein. (133 aa) |
| | ENSPMGP00000010928 | TPR_REGION domain-containing protein. (365 aa) |
| | ENSPMGP00000005437 | Polymerase (DNA directed), gamma 2, accessory subunit. (455 aa) |
| | ENSPMGP00000005554 | RecQ mediated genome instability 2. (149 aa) |
| | ZNF830 | Zinc finger protein 830. (329 aa) |
| | ENSPMGP00000006532 | CTF/NF-I domain-containing protein. (207 aa) |
| | ENSPMGP00000007026 | RNA binding motif protein 48. (354 aa) |
| | ENSPMGP00000007191 | Uncharacterized protein. (533 aa) |
| | ENSPMGP00000007707 | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (465 aa) |
| | ENSPMGP00000007885 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa) |
| | ENSPMGP00000008014 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (896 aa) |
| | ENSPMGP00000008027 | Cyclin E2; Belongs to the cyclin family. (389 aa) |
| | ENSPMGP00000008393 | SAM domain and HD domain 1. (614 aa) |
| | ENSPMGP00000008407 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (562 aa) |
| | ENSPMGP00000008465 | Uncharacterized protein. (364 aa) |
| | ENSPMGP00000008469 | F-box domain-containing protein. (57 aa) |
| | ENSPMGP00000008736 | WRN helicase interacting protein 1. (622 aa) |
| | ENSPMGP00000010861 | Minichromosome maintenance complex binding protein. (628 aa) |
| | ENSPMGP00000009285 | ZPR1 zinc finger. (428 aa) |
| | ENSPMGP00000009464 | GINS complex subunit 1 (Psf1 homolog). (196 aa) |
| | ENSPMGP00000009518 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11. (829 aa) |
| | ENSPMGP00000009664 | Sde2_N_Ubi domain-containing protein. (385 aa) |
| | ENSPMGP00000009808 | Uncharacterized protein. (547 aa) |
| | ENSPMGP00000024630 | Inhibitor of growth protein. (249 aa) |
| | NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (482 aa) |
| | ENSPMGP00000023767 | Uncharacterized protein. (216 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (888 aa) |
| | ENSPMGP00000023582 | Essential meiotic structure-specific endonuclease 1. (475 aa) |
| | ENSPMGP00000023442 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (328 aa) |
| | ENSPMGP00000023441 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (310 aa) |
| | ENSPMGP00000023182 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | ENSPMGP00000022931 | DNA ligase. (895 aa) |
| | ENSPMGP00000022902 | DNA helicase; Belongs to the MCM family. (694 aa) |
| | ENSPMGP00000022771 | DNA_pol_B_thumb domain-containing protein. (54 aa) |
| | ENSPMGP00000022767 | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (202 aa) |
| | ENSPMGP00000021604 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (300 aa) |
| | ENSPMGP00000021513 | Zf-primase domain-containing protein. (206 aa) |
| | ENSPMGP00000021037 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (497 aa) |
| | ENSPMGP00000020510 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (865 aa) |
| | ENSPMGP00000020400 | Replication factor C (activator 1) 4. (358 aa) |
| | ENSPMGP00000020229 | Sirtuin 7. (401 aa) |
| | ENSPMGP00000019989 | DNA helicase; Belongs to the MCM family. (809 aa) |
| | ENSPMGP00000019895 | PHD-type domain-containing protein. (691 aa) |
| | ENSPMGP00000019587 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2554 aa) |
| | ENSPMGP00000019186 | DNA polymerase. (1034 aa) |
| | ENSPMGP00000018529 | Replication factor C (activator 1) 5. (336 aa) |
| | ENSPMGP00000018412 | Polymerase (DNA directed), gamma. (457 aa) |
| | ENSPMGP00000018175 | Uncharacterized protein. (405 aa) |
| | ENSPMGP00000017754 | Twinkle mtDNA helicase. (709 aa) |
| | ENSPMGP00000017472 | Chromatin assembly factor 1, subunit A (p150). (788 aa) |
| | ENSPMGP00000017286 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (793 aa) |
| | ENSPMGP00000017091 | D-aminoacyl-tRNA deacylase. (164 aa) |
| | ENSPMGP00000016778 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (246 aa) |
| | ENSPMGP00000016642 | Zgc:110269. (304 aa) |
| | ENSPMGP00000016417 | DNA ligase. (913 aa) |
| | ENSPMGP00000015885 | DNA polymerase. (1380 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (290 aa) |
| | ENSPMGP00000015207 | Tetratricopeptide repeat domain 38. (468 aa) |
| | ENSPMGP00000015103 | Primase and polymerase (DNA-directed). (506 aa) |
| | ENSPMGP00000014891 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (614 aa) |
| | ENSPMGP00000010000 | THO complex 1. (629 aa) |
| | ENSPMGP00000010071 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (454 aa) |
| | ENSPMGP00000010348 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (495 aa) |
| | ENSPMGP00000010401 | RPA interacting protein. (234 aa) |
| | ENSPMGP00000010735 | SET domain and mariner transposase fusion gene. (160 aa) |
| | ENSPMGP00000010777 | PCNA clamp associated factor. (111 aa) |
| | ENSPMGP00000014791 | Glutamate-rich WD repeat containing 1. (455 aa) |
| | ENSPMGP00000014113 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (568 aa) |
| | ENSPMGP00000003172 | Uncharacterized protein. (91 aa) |
| | ENSPMGP00000003957 | Replication factor C (activator 1) 2. (342 aa) |
| | ENSPMGP00000003968 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (248 aa) |
| | ENSPMGP00000004039 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (559 aa) |
| | ENSPMGP00000004081 | Centromere protein X. (86 aa) |
| | ENSPMGP00000004403 | Nucleolar complex protein 3 homolog. (735 aa) |
| | ENSPMGP00000004468 | Retinoblastoma binding protein 4, like. (426 aa) |
| | ENSPMGP00000004524 | Uncharacterized protein. (243 aa) |
| | CINP | Cyclin dependent kinase 2 interacting protein. (207 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1273 aa) |
| | ENSPMGP00000005307 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa) |
| | ENSPMGP00000013782 | Retinoblastoma binding protein 4. (398 aa) |
| | DONSON | Downstream neighbor of SON. (439 aa) |
| | ENSPMGP00000013738 | Zinc finger, RAN-binding domain containing 3. (997 aa) |
| | ENSPMGP00000013512 | DNA topoisomerase II binding protein 1. (1436 aa) |
