(91 nodes) Bone development network (Periophthalmus magnuspinnatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPMGP00000029255	Cellular communication network factor 4a. (351 aa)
	ENSPMGP00000000268	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1688 aa)
	ENSPMGP00000000814	Checkpoint suppressor 1. (308 aa)
	ENSPMGP00000000912	Protein tyrosine phosphatase non-receptor type 11b. (562 aa)
	SRC	Tyrosine-protein kinase. (469 aa)
	ENSPMGP00000001509	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (263 aa)
	ENSPMGP00000001827	MADS-box domain-containing protein. (263 aa)
	ENSPMGP00000001903	Fras1 related extracellular matrix 1b. (1945 aa)
	ENSPMGP00000002125	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (860 aa)
	ENSPMGP00000002135	Bromo domain-containing protein. (84 aa)
	ENSPMGP00000003000	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1250 aa)
	ENSPMGP00000003071	EBP cholestenol delta-isomerase. (225 aa)
	ENSPMGP00000003298	Annexin. (676 aa)
	ENSPMGP00000003768	Semaphorin 4e; Belongs to the semaphorin family. (746 aa)
	EPYC	Epiphycan. (265 aa)
	ENSPMGP00000004116	Uncharacterized protein. (283 aa)
	ENSPMGP00000004594	Ectodysplasin A receptor. (518 aa)
	ENSPMGP00000004917	Solute carrier family 38 member 10. (611 aa)
	ENSPMGP00000005182	Integrin beta. (275 aa)
	ENSPMGP00000005462	Phosphate regulating endopeptidase homolog, X-linked. (705 aa)
	ENSPMGP00000005476	Membrane-bound transcription factor peptidase, site 2. (499 aa)
	ENSPMGP00000005751	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (701 aa)
	ENSPMGP00000006039	SH2B adaptor protein 3. (498 aa)
	ENSPMGP00000007144	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
	ENSPMGP00000007641	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (513 aa)
	ENSPMGP00000007793	SH2 domain-containing protein. (48 aa)
	ENSPMGP00000007839	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (480 aa)
	ENSPMGP00000008380	Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family. (436 aa)
	ENSPMGP00000008627	Gla domain-containing protein. (210 aa)
	ENSPMGP00000008920	Leucine rich repeat containing 17. (397 aa)
	ENSPMGP00000009196	Peroxisomal biogenesis factor 7. (325 aa)
	ENSPMGP00000009278	Golgi glycoprotein 1a. (1032 aa)
	ENSPMGP00000009333	Muscle segment homeobox 1a. (152 aa)
	ENSPMGP00000009505	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family. (410 aa)
	ENSPMGP00000009777	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	ENSPMGP00000009878	Protein kinase domain-containing protein. (86 aa)
	ENSPMGP00000010010	ATPase H+ transporting accessory protein 1b. (445 aa)
	ENSPMGP00000010346	RAB23, member RAS oncogene family. (202 aa)
	ENSPMGP00000010473	Dehydrogenase/reductase (SDR family) member 3b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	ENSPMGP00000010504	Uncharacterized protein. (381 aa)
	ENSPMGP00000011760	Extracellular sulfatase. (891 aa)
	ENSPMGP00000012936	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (440 aa)
	ENSPMGP00000013079	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (795 aa)
	ENSPMGP00000013888	Sp5 transcription factor a. (361 aa)
	ENSPMGP00000014410	Thyroid hormone receptor interactor 11. (1964 aa)
	ENSPMGP00000014571	Fras1 related extracellular matrix 1a. (2161 aa)
	ENSPMGP00000014870	Phosphatase, orphan 2. (239 aa)
	ENSPMGP00000015140	Serum response factor b. (528 aa)
	ENSPMGP00000015181	Ripply transcriptional repressor 1. (130 aa)
	ENSPMGP00000015566	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (69 aa)
	ENSPMGP00000016193	Uncharacterized protein. (759 aa)
	ENSPMGP00000016485	Integrin_b_cyt domain-containing protein. (92 aa)
	ENSPMGP00000016967	Ankyrin repeat domain 11. (2717 aa)
	ENSPMGP00000017090	Intraflagellar transport 80 homolog (Chlamydomonas). (780 aa)
	ENSPMGP00000017353	Bone morphogenetic protein 16. (444 aa)
	ABI1	Abl-interactor 1a. (462 aa)
	ENSPMGP00000017497	Si:ch211-129c21.1; Belongs to the semaphorin family. (715 aa)
	SPNS2	Sphingolipid transporter 2. (491 aa)
	ENSPMGP00000018882	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (123 aa)
	ENSPMGP00000018965	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (980 aa)
	ENSPMGP00000019409	Bone morphogenetic protein 4. (392 aa)
	ENSPMGP00000019626	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b; Belongs to the serpin family. (403 aa)
	ENSPMGP00000019669	Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis). (358 aa)
	ENSPMGP00000021081	Glycoprotein IX (platelet). (226 aa)
	ENSPMGP00000021270	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	ENSPMGP00000022010	E1A binding protein p300 b. (2642 aa)
	ENSPMGP00000022134	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (189 aa)
	ENSPMGP00000022715	Glycoprotein Ib platelet subunit beta. (206 aa)
	ENSPMGP00000022852	Leptin receptor. (1036 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (383 aa)
	ENSPMGP00000023380	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
	ENSPMGP00000023392	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (385 aa)
	ENSPMGP00000023761	SH2 domain-containing protein. (76 aa)
	ENSPMGP00000024026	Leucine-rich repeat kinase 1. (1179 aa)
	ENSPMGP00000024092	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (287 aa)
	ENSPMGP00000024731	Nuclear receptor binding SET domain protein 2. (1123 aa)
	TTC9	Tetratricopeptide repeat domain 9. (234 aa)
	ENSPMGP00000025032	Abl-interactor 1b. (477 aa)
	ENSPMGP00000025058	Uncharacterized protein. (260 aa)
	ENSPMGP00000025486	Checkpoint suppressor 1. (193 aa)
	ENSPMGP00000025652	FAM20C golgi associated secretory pathway kinase a. (577 aa)
	MEF2D	MADS-box domain-containing protein. (526 aa)
	ENSPMGP00000026849	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (548 aa)
	ENSPMGP00000026954	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (195 aa)
	ENSPMGP00000027308	ATPase H+ transporting accessory protein 1a. (486 aa)
	ENSPMGP00000027510	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (570 aa)
	ENSPMGP00000028210	Tripartite motif containing 45. (536 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (818 aa)
	ENSPMGP00000028506	Ig-like domain-containing protein. (120 aa)
	ENSPMGP00000028678	BRCT domain-containing protein. (508 aa)
	ENSPMGP00000028842	Sulfatase 2a. (855 aa)

Your Current Organism:

Periophthalmus magnuspinnatus

NCBI taxonomy Id: 409849
Other names: P. magnuspinnatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	ENSPMGP00000007839	ENSPMGP00000017474	ENSPMGP00000007839	Abl-interactor 1a.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.412
ABI1	ENSPMGP00000009878	ENSPMGP00000017474	ENSPMGP00000009878	Abl-interactor 1a.	Protein kinase domain-containing protein.	0.555
ABI1	ENSPMGP00000018965	ENSPMGP00000017474	ENSPMGP00000018965	Abl-interactor 1a.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.412
ABI1	ENSPMGP00000026849	ENSPMGP00000017474	ENSPMGP00000026849	Abl-interactor 1a.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.411
ABI1	ENSPMGP00000027510	ENSPMGP00000017474	ENSPMGP00000027510	Abl-interactor 1a.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.411
ABI1	SRC	ENSPMGP00000017474	ENSPMGP00000001419	Abl-interactor 1a.	Tyrosine-protein kinase.	0.555
ENSPMGP00000000268	ENSPMGP00000002135	ENSPMGP00000000268	ENSPMGP00000002135	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Bromo domain-containing protein.	0.601
ENSPMGP00000000268	ENSPMGP00000008380	ENSPMGP00000000268	ENSPMGP00000008380	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family.	0.648
ENSPMGP00000000268	ENSPMGP00000009878	ENSPMGP00000000268	ENSPMGP00000009878	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Protein kinase domain-containing protein.	0.671
ENSPMGP00000000268	ENSPMGP00000013079	ENSPMGP00000000268	ENSPMGP00000013079	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.601
ENSPMGP00000000268	ENSPMGP00000017090	ENSPMGP00000000268	ENSPMGP00000017090	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Intraflagellar transport 80 homolog (Chlamydomonas).	0.560
ENSPMGP00000000268	ENSPMGP00000022010	ENSPMGP00000000268	ENSPMGP00000022010	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	E1A binding protein p300 b.	0.768
ENSPMGP00000000268	SPNS2	ENSPMGP00000000268	ENSPMGP00000017626	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Sphingolipid transporter 2.	0.467
ENSPMGP00000000268	SRC	ENSPMGP00000000268	ENSPMGP00000001419	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Tyrosine-protein kinase.	0.671
ENSPMGP00000000814	ENSPMGP00000002135	ENSPMGP00000000814	ENSPMGP00000002135	Checkpoint suppressor 1.	Bromo domain-containing protein.	0.470
ENSPMGP00000000814	ENSPMGP00000013079	ENSPMGP00000000814	ENSPMGP00000013079	Checkpoint suppressor 1.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.470
ENSPMGP00000000814	ENSPMGP00000015140	ENSPMGP00000000814	ENSPMGP00000015140	Checkpoint suppressor 1.	Serum response factor b.	0.487
ENSPMGP00000000814	ENSPMGP00000022010	ENSPMGP00000000814	ENSPMGP00000022010	Checkpoint suppressor 1.	E1A binding protein p300 b.	0.615
ENSPMGP00000000814	ENSPMGP00000025486	ENSPMGP00000000814	ENSPMGP00000025486	Checkpoint suppressor 1.	Checkpoint suppressor 1.	0.911
ENSPMGP00000000912	ENSPMGP00000005182	ENSPMGP00000000912	ENSPMGP00000005182	Protein tyrosine phosphatase non-receptor type 11b.	Integrin beta.	0.623