STRINGSTRING
ENSPMGP00000019989 ENSPMGP00000019989 ENSPMGP00000000027 ENSPMGP00000000027 RPA1 RPA1 ENSPMGP00000002778 ENSPMGP00000002778 ENSPMGP00000003968 ENSPMGP00000003968 ENSPMGP00000007707 ENSPMGP00000007707 ENSPMGP00000007885 ENSPMGP00000007885 ENSPMGP00000009464 ENSPMGP00000009464 ENSPMGP00000010348 ENSPMGP00000010348 ENSPMGP00000012423 ENSPMGP00000012423 NFIX NFIX ENSPMGP00000014113 ENSPMGP00000014113 ENSPMGP00000014891 ENSPMGP00000014891 ENSPMGP00000015885 ENSPMGP00000015885 ENSPMGP00000016417 ENSPMGP00000016417 ENSPMGP00000017286 ENSPMGP00000017286 ENSPMGP00000019186 ENSPMGP00000019186 ENSPMGP00000022902 ENSPMGP00000022902 ENSPMGP00000022931 ENSPMGP00000022931 ENSPMGP00000023441 ENSPMGP00000023441 ENSPMGP00000023442 ENSPMGP00000023442 NFIB NFIB MCM7 MCM7 ENSPMGP00000025147 ENSPMGP00000025147 FEN1 FEN1 ENSPMGP00000026390 ENSPMGP00000026390 ENSPMGP00000026467 ENSPMGP00000026467 ENSPMGP00000026818 ENSPMGP00000026818 ENSPMGP00000028142 ENSPMGP00000028142 ENSPMGP00000029337 ENSPMGP00000029337
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPMGP00000019989DNA helicase; Belongs to the MCM family. (809 aa)
ENSPMGP00000000027DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (587 aa)
ENSPMGP00000002778DNA helicase; Belongs to the MCM family. (809 aa)
ENSPMGP00000003968Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (248 aa)
ENSPMGP00000007707Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (465 aa)
ENSPMGP00000007885DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa)
ENSPMGP00000009464GINS complex subunit 1 (Psf1 homolog). (196 aa)
ENSPMGP00000010348DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (495 aa)
ENSPMGP00000012423DNA primase; Belongs to the eukaryotic-type primase small subunit family. (405 aa)
NFIXNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (459 aa)
ENSPMGP00000014113Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (568 aa)
ENSPMGP00000014891FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (614 aa)
ENSPMGP00000015885DNA polymerase. (1380 aa)
ENSPMGP00000016417DNA ligase. (913 aa)
ENSPMGP00000017286Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (793 aa)
ENSPMGP00000019186DNA polymerase. (1034 aa)
ENSPMGP00000022902DNA helicase; Belongs to the MCM family. (694 aa)
ENSPMGP00000022931DNA ligase. (895 aa)
ENSPMGP00000023441DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (310 aa)
ENSPMGP00000023442DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (328 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (482 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
ENSPMGP00000025147DNA helicase; Belongs to the MCM family. (791 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa)
ENSPMGP00000026390DNA helicase; Belongs to the MCM family. (890 aa)
ENSPMGP00000026467Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (798 aa)
ENSPMGP00000026818DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa)
ENSPMGP00000028142Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (412 aa)
ENSPMGP00000029337Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (473 aa)
Your Current Organism:
Periophthalmus magnuspinnatus
NCBI taxonomy Id: 409849
Other names: P. magnuspinnatus
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.