STRINGSTRING
ENSPMGP00000022771 ENSPMGP00000022771 ENSPMGP00000010788 ENSPMGP00000010788 ENSPMGP00000011036 ENSPMGP00000011036 ENSPMGP00000011542 ENSPMGP00000011542 RCBTB1 RCBTB1 ENSPMGP00000014113 ENSPMGP00000014113 ENSPMGP00000016642 ENSPMGP00000016642 ENSPMGP00000018021 ENSPMGP00000018021 ENSPMGP00000018175 ENSPMGP00000018175 ENSPMGP00000018529 ENSPMGP00000018529 ENSPMGP00000019186 ENSPMGP00000019186 ENSPMGP00000020400 ENSPMGP00000020400 ENSPMGP00000020518 ENSPMGP00000020518 ENSPMGP00000022767 ENSPMGP00000022767 ENSPMGP00000010557 ENSPMGP00000010557 ENSPMGP00000023441 ENSPMGP00000023441 ENSPMGP00000023442 ENSPMGP00000023442 FEN1 FEN1 ENSPMGP00000026408 ENSPMGP00000026408 ENSPMGP00000027525 ENSPMGP00000027525 ENSPMGP00000027896 ENSPMGP00000027896 ENSPMGP00000028425 ENSPMGP00000028425 ENSPMGP00000028598 ENSPMGP00000028598 ENSPMGP00000029368 ENSPMGP00000029368 ENSPMGP00000029939 ENSPMGP00000029939 ENSPMGP00000030014 ENSPMGP00000030014 RPA1 RPA1 ENSPMGP00000001872 ENSPMGP00000001872 ENSPMGP00000002767 ENSPMGP00000002767 ENSPMGP00000030015 ENSPMGP00000030015 ENSPMGP00000002787 ENSPMGP00000002787 ENSPMGP00000002793 ENSPMGP00000002793 ENSPMGP00000002858 ENSPMGP00000002858 ENSPMGP00000003957 ENSPMGP00000003957 ENSPMGP00000003968 ENSPMGP00000003968 ENSPMGP00000004772 ENSPMGP00000004772 ENSPMGP00000005307 ENSPMGP00000005307 ENSPMGP00000005337 ENSPMGP00000005337 ENSPMGP00000006344 ENSPMGP00000006344
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPMGP00000022771DNA_pol_B_thumb domain-containing protein. (54 aa)
ENSPMGP00000010788Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (975 aa)
ENSPMGP00000011036DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (549 aa)
ENSPMGP00000011542ATPase_AAA_core domain-containing protein. (799 aa)
RCBTB1Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (350 aa)
ENSPMGP00000014113Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (568 aa)
ENSPMGP00000016642Zgc:110269. (304 aa)
ENSPMGP00000018021Von Willebrand factor A domain containing 5B2. (976 aa)
ENSPMGP00000018175Uncharacterized protein. (405 aa)
ENSPMGP00000018529Replication factor C (activator 1) 5. (336 aa)
ENSPMGP00000019186DNA polymerase. (1034 aa)
ENSPMGP00000020400Replication factor C (activator 1) 4. (358 aa)
ENSPMGP00000020518DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (333 aa)
ENSPMGP00000022767DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (202 aa)
ENSPMGP00000010557Methionine sulfoxide reductase B1b. (383 aa)
ENSPMGP00000023441DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (310 aa)
ENSPMGP00000023442DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (328 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa)
ENSPMGP00000026408Replication protein A3. (122 aa)
ENSPMGP00000027525Polymerase (DNA-directed), epsilon 4, accessory subunit. (131 aa)
ENSPMGP00000027896Si:dkey-28b4.7. (119 aa)
ENSPMGP00000028425Uncharacterized protein. (725 aa)
ENSPMGP00000028598Polymerase (DNA directed), delta 2, regulatory subunit. (446 aa)
ENSPMGP00000029368Replication factor C (activator 1) 3. (270 aa)
ENSPMGP00000029939ADP-ribosylhydrolase like 2. (385 aa)
ENSPMGP00000030014BRCT domain-containing protein. (398 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (587 aa)
ENSPMGP00000001872Poly (ADP-ribose) glycohydrolase a. (626 aa)
ENSPMGP00000002767Dpoe2NT domain-containing protein. (92 aa)
ENSPMGP00000030015RFC1 domain-containing protein. (135 aa)
ENSPMGP00000002787Polymerase (DNA directed), epsilon 2. (325 aa)
ENSPMGP00000002793Poly [ADP-ribose] polymerase. (624 aa)
ENSPMGP00000002858Uncharacterized protein. (158 aa)
ENSPMGP00000003957Replication factor C (activator 1) 2. (342 aa)
ENSPMGP00000003968Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (248 aa)
ENSPMGP00000004772Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (571 aa)
ENSPMGP00000005307Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa)
ENSPMGP00000005337Replication protein A2. (280 aa)
ENSPMGP00000006344Poly [ADP-ribose] polymerase. (532 aa)
Your Current Organism:
Periophthalmus magnuspinnatus
NCBI taxonomy Id: 409849
Other names: P. magnuspinnatus
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