STRINGSTRING
ENSPMGP00000019186 ENSPMGP00000019186 ENSPMGP00000013548 ENSPMGP00000013548 RCBTB1 RCBTB1 ENSPMGP00000012423 ENSPMGP00000012423 ENSPMGP00000012369 ENSPMGP00000012369 ENSPMGP00000011677 ENSPMGP00000011677 ENSPMGP00000010858 ENSPMGP00000010858 ENSPMGP00000010672 ENSPMGP00000010672 ENSPMGP00000010557 ENSPMGP00000010557 ENSPMGP00000010348 ENSPMGP00000010348 ENSPMGP00000010052 ENSPMGP00000010052 ENSPMGP00000008747 ENSPMGP00000008747 ENSPMGP00000008667 ENSPMGP00000008667 ENSPMGP00000008638 ENSPMGP00000008638 ENSPMGP00000008434 ENSPMGP00000008434 ENSPMGP00000008014 ENSPMGP00000008014 ENSPMGP00000007885 ENSPMGP00000007885 ENSPMGP00000007496 ENSPMGP00000007496 ENSPMGP00000005337 ENSPMGP00000005337 ENSPMGP00000005322 ENSPMGP00000005322 ENSPMGP00000005178 ENSPMGP00000005178 ENSPMGP00000004848 ENSPMGP00000004848 ENSPMGP00000004772 ENSPMGP00000004772 ENSPMGP00000004122 ENSPMGP00000004122 ENSPMGP00000027255 ENSPMGP00000027255 ENSPMGP00000026851 ENSPMGP00000026851 ENSPMGP00000026544 ENSPMGP00000026544 ENSPMGP00000026408 ENSPMGP00000026408 ENSPMGP00000026072 ENSPMGP00000026072 FEN1 FEN1 ENSPMGP00000024898 ENSPMGP00000024898 ENSPMGP00000000071 ENSPMGP00000000071 RPA1 RPA1 ANKRD66 ANKRD66 ENSPMGP00000001334 ENSPMGP00000001334 ENSPMGP00000001504 ENSPMGP00000001504 ENSPMGP00000001519 ENSPMGP00000001519 ENSPMGP00000002223 ENSPMGP00000002223 PIF1 PIF1 ENSPMGP00000002858 ENSPMGP00000002858 ENSPMGP00000003376 ENSPMGP00000003376 ENSPMGP00000003741 ENSPMGP00000003741 PPP6C PPP6C ENSPMGP00000003939 ENSPMGP00000003939 ENSPMGP00000003957 ENSPMGP00000003957 ENSPMGP00000003968 ENSPMGP00000003968 ENSPMGP00000024762 ENSPMGP00000024762 ENSPMGP00000024294 ENSPMGP00000024294 ENSPMGP00000023998 ENSPMGP00000023998 ENSPMGP00000023271 ENSPMGP00000023271 ENSPMGP00000022998 ENSPMGP00000022998 ENSPMGP00000022329 ENSPMGP00000022329 ENSPMGP00000021764 ENSPMGP00000021764 ENSPMGP00000021762 ENSPMGP00000021762 H4C2 H4C2 ENSPMGP00000020400 ENSPMGP00000020400 ENSPMGP00000020304 ENSPMGP00000020304 ENSPMGP00000019895 ENSPMGP00000019895 ENSPMGP00000019841 ENSPMGP00000019841 ENSPMGP00000019478 ENSPMGP00000019478 ENSPMGP00000019300 ENSPMGP00000019300 ENSPMGP00000019260 ENSPMGP00000019260 ENSPMGP00000013868 ENSPMGP00000013868 ENSPMGP00000018529 ENSPMGP00000018529 ENSPMGP00000018443 ENSPMGP00000018443 ENSPMGP00000018175 ENSPMGP00000018175 ENSPMGP00000017641 ENSPMGP00000017641 ENSPMGP00000017635 ENSPMGP00000017635 ENSPMGP00000017300 ENSPMGP00000017300 ENSPMGP00000017107 ENSPMGP00000017107 ENSPMGP00000016642 ENSPMGP00000016642 ENSPMGP00000016444 ENSPMGP00000016444 ENSPMGP00000016158 ENSPMGP00000016158 ENSPMGP00000016157 ENSPMGP00000016157 ENSPMGP00000016014 ENSPMGP00000016014 ENSPMGP00000015885 ENSPMGP00000015885 ENSPMGP00000015873 ENSPMGP00000015873 ENSPMGP00000015665 ENSPMGP00000015665 ENSPMGP00000014735 ENSPMGP00000014735 ENSPMGP00000014331 ENSPMGP00000014331 ENSPMGP00000014257 ENSPMGP00000014257 ENSPMGP00000014113 ENSPMGP00000014113 ENSPMGP00000013995 ENSPMGP00000013995 ENSPMGP00000030015 ENSPMGP00000030015 ENSPMGP00000030014 ENSPMGP00000030014 ENSPMGP00000029905 ENSPMGP00000029905 ENSPMGP00000029829 ENSPMGP00000029829 ENSPMGP00000029368 ENSPMGP00000029368 RTEL1 RTEL1 ENSPMGP00000028905 ENSPMGP00000028905 ENSPMGP00000028598 ENSPMGP00000028598 ENSPMGP00000028205 ENSPMGP00000028205 ENSPMGP00000027942 ENSPMGP00000027942 ENSPMGP00000027900 ENSPMGP00000027900 ENSPMGP00000027896 ENSPMGP00000027896
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPMGP00000019186DNA polymerase. (1034 aa)
ENSPMGP00000013548WD repeat containing, antisense to TP53. (437 aa)
RCBTB1Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (350 aa)
ENSPMGP00000012423DNA primase; Belongs to the eukaryotic-type primase small subunit family. (405 aa)
ENSPMGP00000012369Histone H2B; Belongs to the histone H2B family. (111 aa)
ENSPMGP00000011677Uncharacterized protein. (151 aa)
ENSPMGP00000010858Telomeric repeat binding factor (NIMA-interacting) 1. (301 aa)
ENSPMGP00000010672SHQ1, H/ACA ribonucleoprotein assembly factor. (580 aa)
ENSPMGP00000010557Methionine sulfoxide reductase B1b. (383 aa)
ENSPMGP00000010348DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (495 aa)
ENSPMGP00000010052annotation not available (124 aa)
ENSPMGP00000008747Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
ENSPMGP00000008667Histone H2B; Belongs to the histone H2B family. (110 aa)
ENSPMGP00000008638Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSPMGP00000008434Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (99 aa)
ENSPMGP00000008014ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (896 aa)
ENSPMGP00000007885DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa)
ENSPMGP00000007496Uncharacterized protein. (131 aa)
ENSPMGP00000005337Replication protein A2. (280 aa)
ENSPMGP00000005322Uncharacterized protein. (141 aa)
ENSPMGP00000005178Ankyrin repeat domain 44. (980 aa)
ENSPMGP00000004848Dyskeratosis congenita 1, dyskerin. (531 aa)
ENSPMGP00000004772Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (571 aa)
ENSPMGP00000004122Histone H2A; Belongs to the histone H2A family. (136 aa)
ENSPMGP00000027255H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (229 aa)
ENSPMGP00000026851Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)
ENSPMGP00000026544RecQ helicase-like 4. (1317 aa)
ENSPMGP00000026408Replication protein A3. (122 aa)
ENSPMGP00000026072Exonuclease 3'-5' domain containing 2. (626 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa)
ENSPMGP00000024898Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (264 aa)
ENSPMGP00000000071TruB pseudouridine (psi) synthase family member 1. (277 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (587 aa)
ANKRD66Ankyrin repeat domain 66. (164 aa)
ENSPMGP00000001334Histone H2A; Belongs to the histone H2A family. (134 aa)
ENSPMGP00000001504Uncharacterized protein; Belongs to the histone H2A family. (245 aa)
ENSPMGP00000001519DNA replication helicase/nuclease 2. (918 aa)
ENSPMGP00000002223Uncharacterized protein. (458 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (630 aa)
ENSPMGP00000002858Uncharacterized protein. (158 aa)
ENSPMGP00000003376Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (163 aa)
ENSPMGP00000003741Histone H2A; Belongs to the histone H2A family. (135 aa)
PPP6CSerine/threonine-protein phosphatase. (283 aa)
ENSPMGP00000003939Uncharacterized protein; Belongs to the histone H2B family. (103 aa)
ENSPMGP00000003957Replication factor C (activator 1) 2. (342 aa)
ENSPMGP00000003968Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (248 aa)
ENSPMGP00000024762ANK_REP_REGION domain-containing protein. (1005 aa)
ENSPMGP00000024294Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1062 aa)
ENSPMGP00000023998annotation not available (124 aa)
ENSPMGP00000023271TINF2_N domain-containing protein. (445 aa)
ENSPMGP00000022998Histone H2A; Belongs to the histone H2A family. (137 aa)
ENSPMGP00000022329Cyclin A1; Belongs to the cyclin family. (399 aa)
ENSPMGP00000021764Histone H2B; Belongs to the histone H2B family. (128 aa)
ENSPMGP00000021762Histone H2A; Belongs to the histone H2A family. (130 aa)
H4C2H4 clustered histone 2. (103 aa)
ENSPMGP00000020400Replication factor C (activator 1) 4. (358 aa)
ENSPMGP00000020304CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae). (776 aa)
ENSPMGP00000019895PHD-type domain-containing protein. (691 aa)
ENSPMGP00000019841Serine/threonine-protein phosphatase. (283 aa)
ENSPMGP00000019478Histone H2A; Belongs to the histone H2A family. (97 aa)
ENSPMGP00000019300Uncharacterized protein; Belongs to the histone H2B family. (115 aa)
ENSPMGP00000019260annotation not available (245 aa)
ENSPMGP00000013868Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
ENSPMGP00000018529Replication factor C (activator 1) 5. (336 aa)
ENSPMGP00000018443Histone H2B; Belongs to the histone H2B family. (108 aa)
ENSPMGP00000018175Uncharacterized protein. (405 aa)
ENSPMGP00000017641RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (48 aa)
ENSPMGP00000017635RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (354 aa)
ENSPMGP00000017300Cyclin A2; Belongs to the cyclin family. (411 aa)
ENSPMGP00000017107STN1 subunit of CST complex. (346 aa)
ENSPMGP00000016642Zgc:110269. (304 aa)
ENSPMGP00000016444Myb-like domain-containing protein. (490 aa)
ENSPMGP00000016158Histone H2B; Belongs to the histone H2B family. (156 aa)
ENSPMGP00000016157Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (165 aa)
ENSPMGP00000016014Histone H2B; Belongs to the histone H2B family. (118 aa)
ENSPMGP00000015885DNA polymerase. (1380 aa)
ENSPMGP00000015873Histone_H2A_C domain-containing protein; Belongs to the histone H2A family. (116 aa)
ENSPMGP00000015665Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSPMGP00000014735TEN1 subunit of CST complex. (133 aa)
ENSPMGP00000014331Ankyrin repeat domain 28b. (966 aa)
ENSPMGP00000014257Telo_bind domain-containing protein. (352 aa)
ENSPMGP00000014113Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (568 aa)
ENSPMGP00000013995Histone H2B; Belongs to the histone H2B family. (113 aa)
ENSPMGP00000030015RFC1 domain-containing protein. (135 aa)
ENSPMGP00000030014BRCT domain-containing protein. (398 aa)
ENSPMGP00000029905Death-domain associated protein. (557 aa)
ENSPMGP00000029829CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (126 aa)
ENSPMGP00000029368Replication factor C (activator 1) 3. (270 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1105 aa)
ENSPMGP00000028905Ankyrin repeat domain 52a. (1078 aa)
ENSPMGP00000028598Polymerase (DNA directed), delta 2, regulatory subunit. (446 aa)
ENSPMGP00000028205DNA replication and sister chromatid cohesion 1. (380 aa)
ENSPMGP00000027942Uncharacterized protein. (762 aa)
ENSPMGP00000027900annotation not available (92 aa)
ENSPMGP00000027896Si:dkey-28b4.7. (119 aa)
Your Current Organism:
Periophthalmus magnuspinnatus
NCBI taxonomy Id: 409849
Other names: P. magnuspinnatus
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