STRINGSTRING
RPA1 RPA1 ENSPMGP00000029368 ENSPMGP00000029368 ENSPMGP00000028552 ENSPMGP00000028552 ENSPMGP00000028142 ENSPMGP00000028142 ENSPMGP00000026605 ENSPMGP00000026605 ENSPMGP00000026467 ENSPMGP00000026467 ENSPMGP00000026408 ENSPMGP00000026408 ENSPMGP00000026390 ENSPMGP00000026390 ENSPMGP00000026090 ENSPMGP00000026090 ENSPMGP00000025557 ENSPMGP00000025557 ENSPMGP00000025147 ENSPMGP00000025147 MCM7 MCM7 ENSPMGP00000024898 ENSPMGP00000024898 ENSPMGP00000022902 ENSPMGP00000022902 ENSPMGP00000021513 ENSPMGP00000021513 ENSPMGP00000020400 ENSPMGP00000020400 ENSPMGP00000019989 ENSPMGP00000019989 ENSPMGP00000019587 ENSPMGP00000019587 ENSPMGP00000018529 ENSPMGP00000018529 HUS1 HUS1 ENSPMGP00000014113 ENSPMGP00000014113 ENSPMGP00000013444 ENSPMGP00000013444 RCBTB1 RCBTB1 ENSPMGP00000010440 ENSPMGP00000010440 ENSPMGP00000009758 ENSPMGP00000009758 ENSPMGP00000006737 ENSPMGP00000006737 ENSPMGP00000005957 ENSPMGP00000005957 ENSPMGP00000005337 ENSPMGP00000005337 ENSPMGP00000004772 ENSPMGP00000004772 ENSPMGP00000004508 ENSPMGP00000004508 ENSPMGP00000004039 ENSPMGP00000004039 ENSPMGP00000003957 ENSPMGP00000003957 ENSPMGP00000002858 ENSPMGP00000002858 ENSPMGP00000002778 ENSPMGP00000002778 ENSPMGP00000002554 ENSPMGP00000002554 ENSPMGP00000001324 ENSPMGP00000001324 ENSPMGP00000000505 ENSPMGP00000000505
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (587 aa)
ENSPMGP00000029368Replication factor C (activator 1) 3. (270 aa)
ENSPMGP00000028552RAD1 homolog (S. pombe). (281 aa)
ENSPMGP00000028142Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (412 aa)
ENSPMGP00000026605DBF4 zinc finger. (529 aa)
ENSPMGP00000026467Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (798 aa)
ENSPMGP00000026408Replication protein A3. (122 aa)
ENSPMGP00000026390DNA helicase; Belongs to the MCM family. (890 aa)
ENSPMGP00000026090Cell division cycle 25B. (454 aa)
ENSPMGP00000025557Origin recognition complex, subunit 2. (360 aa)
ENSPMGP00000025147DNA helicase; Belongs to the MCM family. (791 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
ENSPMGP00000024898Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (264 aa)
ENSPMGP00000022902DNA helicase; Belongs to the MCM family. (694 aa)
ENSPMGP00000021513Zf-primase domain-containing protein. (206 aa)
ENSPMGP00000020400Replication factor C (activator 1) 4. (358 aa)
ENSPMGP00000019989DNA helicase; Belongs to the MCM family. (809 aa)
ENSPMGP00000019587ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2554 aa)
ENSPMGP00000018529Replication factor C (activator 1) 5. (336 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (275 aa)
ENSPMGP00000014113Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (568 aa)
ENSPMGP00000013444Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (497 aa)
RCBTB1Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (350 aa)
ENSPMGP00000010440Cell cycle checkpoint control protein; Belongs to the rad9 family. (385 aa)
ENSPMGP00000009758Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (717 aa)
ENSPMGP00000006737RAD17 checkpoint clamp loader component. (472 aa)
ENSPMGP00000005957Checkpoint kinase 1; Belongs to the protein kinase superfamily. (412 aa)
ENSPMGP00000005337Replication protein A2. (280 aa)
ENSPMGP00000004772Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (571 aa)
ENSPMGP00000004508RAD9 checkpoint clamp component B. (183 aa)
ENSPMGP00000004039CDC45 cell division cycle 45 homolog (S. cerevisiae). (559 aa)
ENSPMGP00000003957Replication factor C (activator 1) 2. (342 aa)
ENSPMGP00000002858Uncharacterized protein. (158 aa)
ENSPMGP00000002778DNA helicase; Belongs to the MCM family. (809 aa)
ENSPMGP00000002554Origin recognition complex, subunit 5. (413 aa)
ENSPMGP00000001324ORC_WH_C domain-containing protein. (694 aa)
ENSPMGP00000000505Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (537 aa)
Your Current Organism:
Periophthalmus magnuspinnatus
NCBI taxonomy Id: 409849
Other names: P. magnuspinnatus
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