STRINGSTRING
ENSPMGP00000027525 ENSPMGP00000027525 ENSPMGP00000000505 ENSPMGP00000000505 RPA1 RPA1 ENSPMGP00000001324 ENSPMGP00000001324 ENSPMGP00000002554 ENSPMGP00000002554 ENSPMGP00000002767 ENSPMGP00000002767 ENSPMGP00000002778 ENSPMGP00000002778 ENSPMGP00000002787 ENSPMGP00000002787 ENSPMGP00000004039 ENSPMGP00000004039 ENSPMGP00000005307 ENSPMGP00000005307 ENSPMGP00000005337 ENSPMGP00000005337 ENSPMGP00000007240 ENSPMGP00000007240 ENSPMGP00000007885 ENSPMGP00000007885 ENSPMGP00000009758 ENSPMGP00000009758 ENSPMGP00000010348 ENSPMGP00000010348 ENSPMGP00000010557 ENSPMGP00000010557 ENSPMGP00000012423 ENSPMGP00000012423 ENSPMGP00000013444 ENSPMGP00000013444 ENSPMGP00000014113 ENSPMGP00000014113 ENSPMGP00000015885 ENSPMGP00000015885 ENSPMGP00000019989 ENSPMGP00000019989 ENSPMGP00000021513 ENSPMGP00000021513 ENSPMGP00000022902 ENSPMGP00000022902 ENSPMGP00000023441 ENSPMGP00000023441 ENSPMGP00000023442 ENSPMGP00000023442 ENSPMGP00000024137 ENSPMGP00000024137 ENSPMGP00000024898 ENSPMGP00000024898 MCM7 MCM7 ENSPMGP00000025147 ENSPMGP00000025147 ENSPMGP00000025557 ENSPMGP00000025557 ENSPMGP00000026390 ENSPMGP00000026390 ENSPMGP00000026408 ENSPMGP00000026408 ENSPMGP00000026467 ENSPMGP00000026467 ENSPMGP00000026605 ENSPMGP00000026605 ENSPMGP00000027527 ENSPMGP00000027527 ENSPMGP00000028142 ENSPMGP00000028142 ENSPMGP00000028190 ENSPMGP00000028190
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPMGP00000027525Polymerase (DNA-directed), epsilon 4, accessory subunit. (131 aa)
ENSPMGP00000000505Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (537 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (587 aa)
ENSPMGP00000001324ORC_WH_C domain-containing protein. (694 aa)
ENSPMGP00000002554Origin recognition complex, subunit 5. (413 aa)
ENSPMGP00000002767Dpoe2NT domain-containing protein. (92 aa)
ENSPMGP00000002778DNA helicase; Belongs to the MCM family. (809 aa)
ENSPMGP00000002787Polymerase (DNA directed), epsilon 2. (325 aa)
ENSPMGP00000004039CDC45 cell division cycle 45 homolog (S. cerevisiae). (559 aa)
ENSPMGP00000005307Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa)
ENSPMGP00000005337Replication protein A2. (280 aa)
ENSPMGP00000007240Chromatin licensing and DNA replication factor 1. (653 aa)
ENSPMGP00000007885DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa)
ENSPMGP00000009758Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (717 aa)
ENSPMGP00000010348DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (495 aa)
ENSPMGP00000010557Methionine sulfoxide reductase B1b. (383 aa)
ENSPMGP00000012423DNA primase; Belongs to the eukaryotic-type primase small subunit family. (405 aa)
ENSPMGP00000013444Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (497 aa)
ENSPMGP00000014113Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (568 aa)
ENSPMGP00000015885DNA polymerase. (1380 aa)
ENSPMGP00000019989DNA helicase; Belongs to the MCM family. (809 aa)
ENSPMGP00000021513Zf-primase domain-containing protein. (206 aa)
ENSPMGP00000022902DNA helicase; Belongs to the MCM family. (694 aa)
ENSPMGP00000023441DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (310 aa)
ENSPMGP00000023442DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (328 aa)
ENSPMGP00000024137Uncharacterized protein. (114 aa)
ENSPMGP00000024898Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (264 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
ENSPMGP00000025147DNA helicase; Belongs to the MCM family. (791 aa)
ENSPMGP00000025557Origin recognition complex, subunit 2. (360 aa)
ENSPMGP00000026390DNA helicase; Belongs to the MCM family. (890 aa)
ENSPMGP00000026408Replication protein A3. (122 aa)
ENSPMGP00000026467Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (798 aa)
ENSPMGP00000026605DBF4 zinc finger. (529 aa)
ENSPMGP00000027527SCY domain-containing protein. (116 aa)
ENSPMGP00000028142Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (412 aa)
ENSPMGP00000028190Geminin DNA replication inhibitor. (232 aa)
Your Current Organism:
Periophthalmus magnuspinnatus
NCBI taxonomy Id: 409849
Other names: P. magnuspinnatus
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.