Your Input: | |
| | ENSPMGP00000022579 | Uncharacterized protein. (199 aa) |
| | ENSPMGP00000027704 | KxDL motif containing 1. (173 aa) |
| | ENSPMGP00000027896 | Si:dkey-28b4.7. (119 aa) |
| | ENSPMGP00000027900 | annotation not available (92 aa) |
| | ENSPMGP00000028074 | Proteasome activator subunit 1. (194 aa) |
| | ENSPMGP00000028142 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (412 aa) |
| | ENSPMGP00000028190 | Geminin DNA replication inhibitor. (232 aa) |
| | ENSPMGP00000028425 | Uncharacterized protein. (725 aa) |
| | ENSPMGP00000028598 | Polymerase (DNA directed), delta 2, regulatory subunit. (446 aa) |
| | ENSPMGP00000028996 | Proteasome subunit beta. (200 aa) |
| | ENSPMGP00000029063 | Proteasome subunit beta. (274 aa) |
| | ENSPMGP00000029368 | Replication factor C (activator 1) 3. (270 aa) |
| | ENSPMGP00000029438 | Importin subunit alpha; Belongs to the importin alpha family. (539 aa) |
| | ENSPMGP00000030014 | BRCT domain-containing protein. (398 aa) |
| | ENSPMGP00000030015 | RFC1 domain-containing protein. (135 aa) |
| | ENSPMGP00000014733 | Proteasome inhibitor subunit 1. (268 aa) |
| | ENSPMGP00000014800 | Ubiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (245 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (290 aa) |
| | ENSPMGP00000015495 | Cell division cycle 16 homolog (S. cerevisiae). (605 aa) |
| | ENSPMGP00000015665 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | ENSPMGP00000015781 | Proteasome activator subunit 2. (184 aa) |
| | ENSPMGP00000015845 | APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa) |
| | ENSPMGP00000015873 | Histone_H2A_C domain-containing protein; Belongs to the histone H2A family. (116 aa) |
| | ENSPMGP00000015885 | DNA polymerase. (1380 aa) |
| | ENSPMGP00000016014 | Histone H2B; Belongs to the histone H2B family. (118 aa) |
| | ENSPMGP00000016071 | Proteasome subunit beta. (212 aa) |
| | ENSPMGP00000016157 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (165 aa) |
| | ENSPMGP00000016158 | Histone H2B; Belongs to the histone H2B family. (156 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6. (173 aa) |
| | ENSPMGP00000016362 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (220 aa) |
| | ENSPMGP00000016642 | Zgc:110269. (304 aa) |
| | ENSPMGP00000016802 | Proteasome subunit beta. (274 aa) |
| | ENSPMGP00000016803 | Proteasome subunit beta 13a. (131 aa) |
| | ENSPMGP00000017300 | Cyclin A2; Belongs to the cyclin family. (411 aa) |
| | ENSPMGP00000017384 | Uncharacterized protein. (274 aa) |
| | ENSPMGP00000018175 | Uncharacterized protein. (405 aa) |
| | ENSPMGP00000018443 | Histone H2B; Belongs to the histone H2B family. (108 aa) |
| | ENSPMGP00000018529 | Replication factor C (activator 1) 5. (336 aa) |
| | ENSPMGP00000018778 | Proteasome 26S subunit, non-ATPase 9. (210 aa) |
| | ENSPMGP00000018869 | BRD4 interacting chromatin remodeling complex associated protein. (1422 aa) |
| | ENSPMGP00000019186 | DNA polymerase. (1034 aa) |
| | ENSPMGP00000019260 | annotation not available (245 aa) |
| | ENSPMGP00000019300 | Uncharacterized protein; Belongs to the histone H2B family. (115 aa) |
| | ENSPMGP00000019478 | Histone H2A; Belongs to the histone H2A family. (97 aa) |
| | ENSPMGP00000019785 | Proteasome 26S subunit, non-ATPase 8. (265 aa) |
| | ENSPMGP00000019989 | DNA helicase; Belongs to the MCM family. (809 aa) |
| | ENSPMGP00000020050 | Cell division cycle 27. (437 aa) |
| | ENSPMGP00000020055 | Cell division cycle 27. (312 aa) |
| | ENSPMGP00000020174 | Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (194 aa) |
| | ENSPMGP00000020400 | Replication factor C (activator 1) 4. (358 aa) |
| | ENSPMGP00000020705 | Proteasome 26S subunit, non-ATPase 3. (499 aa) |
| | ENSPMGP00000020881 | Proteasome endopeptidase complex. (164 aa) |
| | ENSPMGP00000021098 | Uncharacterized protein. (1731 aa) |
| | FZR1 | Fizzy/cell division cycle 20 related 1a. (492 aa) |
| | ENSPMGP00000021513 | Zf-primase domain-containing protein. (206 aa) |
| | ENSPMGP00000021568 | Ubiquitin-like domain-containing protein. (77 aa) |
| | ENSPMGP00000021631 | Uncharacterized protein. (164 aa) |
| | H4C2 | H4 clustered histone 2. (103 aa) |
| | ENSPMGP00000021762 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | ENSPMGP00000021764 | Histone H2B; Belongs to the histone H2B family. (128 aa) |
| | ENSPMGP00000021811 | Pr_beta_C domain-containing protein. (195 aa) |
| | ENSPMGP00000021823 | Histone H3; Belongs to the histone H3 family. (141 aa) |
| | ENSPMGP00000022075 | Ring-box 1, E3 ubiquitin protein ligase. (125 aa) |
| | ENSPMGP00000022329 | Cyclin A1; Belongs to the cyclin family. (399 aa) |
| | ENSPMGP00000025558 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | ENSPMGP00000025557 | Origin recognition complex, subunit 2. (360 aa) |
| | ENSPMGP00000025527 | Proteasome subunit alpha type. (246 aa) |
| | ENSPMGP00000025496 | Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (384 aa) |
| | ENSPMGP00000025346 | Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa) |
| | ENSPMGP00000025147 | DNA helicase; Belongs to the MCM family. (791 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa) |
| | ENSPMGP00000024898 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (264 aa) |
| | ENSPMGP00000024778 | Proteasome subunit beta 5. (324 aa) |
| | ENSPMGP00000024772 | Uncharacterized protein. (332 aa) |
| | ENSPMGP00000024714 | Proteasome subunit alpha type. (241 aa) |
| | ENSPMGP00000024444 | BLM10_mid domain-containing protein. (557 aa) |
| | ENSPMGP00000024440 | DUF3437 domain-containing protein. (330 aa) |
| | ENSPMGP00000024365 | Proteasome 26S subunit, non-ATPase 13. (378 aa) |
| | ENSPMGP00000024137 | Uncharacterized protein. (114 aa) |
| | ENSPMGP00000024077 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (361 aa) |
| | ENSPMGP00000023998 | annotation not available (124 aa) |
| | ENSPMGP00000023701 | S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa) |
| | ENSPMGP00000023678 | Proteasome activator subunit 3. (193 aa) |
| | ENSPMGP00000023648 | Uncharacterized protein. (65 aa) |
| | ENSPMGP00000023642 | Proteasome 26S subunit, ATPase 5. (193 aa) |
| | ENSPMGP00000023442 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (328 aa) |
| | ENSPMGP00000023441 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (310 aa) |
| | ENSPMGP00000023423 | Family with sequence similarity 89 member B. (168 aa) |
| | ENSPMGP00000022998 | Histone H2A; Belongs to the histone H2A family. (137 aa) |
| | ENSPMGP00000022902 | DNA helicase; Belongs to the MCM family. (694 aa) |
| | ENSPMGP00000027614 | Histone H2A; Belongs to the histone H2A family. (90 aa) |
| | ENSPMGP00000027527 | SCY domain-containing protein. (116 aa) |
| | ENSPMGP00000027525 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (131 aa) |
| | ENSPMGP00000027120 | Anaphase promoting complex subunit 15. (126 aa) |
| | ENSPMGP00000026851 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa) |
| | ENSPMGP00000026818 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa) |
| | ENSPMGP00000026743 | annotation not available (136 aa) |
| | ENSPMGP00000026740 | annotation not available (136 aa) |
| | H3-3B | H3.3 histone B. (136 aa) |
| | ENSPMGP00000026707 | Importin subunit alpha; Belongs to the importin alpha family. (525 aa) |
| | ENSPMGP00000026648 | Proteasome subunit alpha type. (243 aa) |
| | ENSPMGP00000026605 | DBF4 zinc finger. (529 aa) |
| | ENSPMGP00000026467 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (798 aa) |
| | ENSPMGP00000026408 | Replication protein A3. (122 aa) |
| | ENSPMGP00000026390 | DNA helicase; Belongs to the MCM family. (890 aa) |
| | ENSPMGP00000026275 | Proteasome endopeptidase complex. (252 aa) |
| | ENSPMGP00000026234 | Anaphase promoting complex subunit 4. (719 aa) |
| | PSMA4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (237 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa) |
| | ENSPMGP00000022577 | Ubiquitin-like domain-containing protein. (108 aa) |
| | ENSPMGP00000025609 | Cyclin E1; Belongs to the cyclin family. (421 aa) |
| | ENSPMGP00000000027 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa) |
| | ENSPMGP00000000058 | Anaphase promoting complex subunit 5. (733 aa) |
| | ENSPMGP00000000393 | Proteasome subunit beta11b. (398 aa) |
| | ENSPMGP00000000505 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (537 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (587 aa) |
| | ENSPMGP00000000671 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | ENSPMGP00000000837 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (789 aa) |
| | ENSPMGP00000001112 | Uncharacterized protein. (89 aa) |
| | ENSPMGP00000001188 | Karyopherin (importin) beta 1. (948 aa) |
| | ENSPMGP00000001227 | Importin subunit alpha; Belongs to the importin alpha family. (510 aa) |
| | ENSPMGP00000001286 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (186 aa) |
| | ENSPMGP00000001296 | Proteasome 26S subunit, non-ATPase 6. (389 aa) |
| | ENSPMGP00000001324 | ORC_WH_C domain-containing protein. (694 aa) |
| | ENSPMGP00000001334 | Histone H2A; Belongs to the histone H2A family. (134 aa) |
| | ENSPMGP00000001474 | Histone H3; Belongs to the histone H3 family. (123 aa) |
| | ENSPMGP00000001504 | Uncharacterized protein; Belongs to the histone H2A family. (245 aa) |
| | ENSPMGP00000001519 | DNA replication helicase/nuclease 2. (918 aa) |
| | ENSPMGP00000001672 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (422 aa) |
| | ENSPMGP00000002105 | Proteasome 26S subunit, non-ATPase 4a. (371 aa) |
| | ENSPMGP00000002234 | Proteasome subunit beta. (237 aa) |
| | ENSPMGP00000002554 | Origin recognition complex, subunit 5. (413 aa) |
| | ENSPMGP00000002666 | Proteasome 26S subunit, non-ATPase 12. (436 aa) |
| | ENSPMGP00000002767 | Dpoe2NT domain-containing protein. (92 aa) |
| | ENSPMGP00000002778 | DNA helicase; Belongs to the MCM family. (809 aa) |
| | ENSPMGP00000002787 | Polymerase (DNA directed), epsilon 2. (325 aa) |
| | ENSPMGP00000002858 | Uncharacterized protein. (158 aa) |
| | ENSPMGP00000003537 | Uncharacterized protein. (155 aa) |
| | ENSPMGP00000003538 | Anaphase promoting complex subunit 1. (1353 aa) |
| | ENSPMGP00000003741 | Histone H2A; Belongs to the histone H2A family. (135 aa) |
| | ENSPMGP00000003939 | Uncharacterized protein; Belongs to the histone H2B family. (103 aa) |
| | ENSPMGP00000003957 | Replication factor C (activator 1) 2. (342 aa) |
| | ENSPMGP00000003968 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (248 aa) |
| | ENSPMGP00000004039 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (559 aa) |
| | ENSPMGP00000004122 | Histone H2A; Belongs to the histone H2A family. (136 aa) |
| | ENSPMGP00000004136 | Proteasome subunit beta 6. (131 aa) |
| | ENSPMGP00000004232 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (206 aa) |
| | ENSPMGP00000004233 | Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (192 aa) |
| | ENSPMGP00000004499 | Family with sequence similarity 89 member A. (176 aa) |
| | ENSPMGP00000004503 | Anaphase promoting complex subunit 7. (565 aa) |
| | ENSPMGP00000004656 | Proteasome 26S subunit, non-ATPase 11b. (422 aa) |
| | ENSPMGP00000004698 | Anaphase promoting complex subunit 16. (108 aa) |
| | ENSPMGP00000004772 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (571 aa) |
| | ENSPMGP00000004890 | Proteasome subunit alpha type. (255 aa) |
| | ENSPMGP00000005159 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | ENSPMGP00000005307 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa) |
| | ENSPMGP00000005323 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (921 aa) |
| | ENSPMGP00000005337 | Replication protein A2. (280 aa) |
| | ENSPMGP00000005402 | Proteasome subunit beta. (215 aa) |
| | ENSPMGP00000005506 | Proteasome 26S subunit, non-ATPase 5. (504 aa) |
| | H3F3B | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | ENSPMGP00000006841 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (397 aa) |
| | ENSPMGP00000006875 | Proteasome subunit beta. (249 aa) |
| | ENSPMGP00000007084 | annotation not available (136 aa) |
| | ENSPMGP00000007240 | Chromatin licensing and DNA replication factor 1. (653 aa) |
| | ENSPMGP00000007639 | WD_REPEATS_REGION domain-containing protein. (496 aa) |
| | ENSPMGP00000007885 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa) |
| | ENSPMGP00000008027 | Cyclin E2; Belongs to the cyclin family. (389 aa) |
| | ENSPMGP00000008263 | CDC23 (cell division cycle 23, yeast, homolog). (563 aa) |
| | ENSPMGP00000008434 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (99 aa) |
| | ENSPMGP00000008638 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | ENSPMGP00000008667 | Histone H2B; Belongs to the histone H2B family. (110 aa) |
| | ENSPMGP00000008747 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa) |
| | ENSPMGP00000008949 | Histone H2A; Belongs to the histone H2A family. (106 aa) |
| | ENSPMGP00000009464 | GINS complex subunit 1 (Psf1 homolog). (196 aa) |
| | ENSPMGP00000009577 | Transmembrane 7 superfamily member 3. (560 aa) |
| | ENSPMGP00000009758 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (717 aa) |
| | ENSPMGP00000009851 | Cullin 1b; Belongs to the cullin family. (776 aa) |
| | ENSPMGP00000010052 | annotation not available (124 aa) |
| | ENSPMGP00000010348 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (495 aa) |
| | ENSPMGP00000010404 | PCI domain-containing protein. (422 aa) |
| | ENSPMGP00000010514 | Proteasome 26S subunit, non-ATPase 4b. (373 aa) |
| | ENSPMGP00000010557 | Methionine sulfoxide reductase B1b. (383 aa) |
| | ENSPMGP00000010714 | Fizzy/cell division cycle 20 related 1b. (280 aa) |
| | ENSPMGP00000010755 | Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa) |
| | ENSPMGP00000011077 | Uncharacterized protein. (133 aa) |
| | ENSPMGP00000011542 | ATPase_AAA_core domain-containing protein. (799 aa) |
| | ENSPMGP00000011637 | Proteasome subunit alpha type. (251 aa) |
| | ENSPMGP00000012075 | Proteasome 26S subunit, non-ATPase 7. (328 aa) |
| | PSMD2 | Proteasome 26S subunit, non-ATPase 2. (341 aa) |
| | PSMD2-2 | Proteasome 26S subunit, non-ATPase 2. (434 aa) |
| | ENSPMGP00000012369 | Histone H2B; Belongs to the histone H2B family. (111 aa) |
| | ENSPMGP00000012423 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (405 aa) |
| | RCBTB1 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (350 aa) |
| | ENSPMGP00000012776 | Proteasome subunit beta. (240 aa) |
| | ENSPMGP00000013376 | Proteasome subunit beta. (220 aa) |
| | ENSPMGP00000013444 | Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (497 aa) |
| | HIST3H3 | Histone H3; Belongs to the histone H3 family. (140 aa) |
| | ENSPMGP00000013868 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa) |
| | ENSPMGP00000013995 | Histone H2B; Belongs to the histone H2B family. (113 aa) |
| | ENSPMGP00000014113 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (568 aa) |
| | ENSPMGP00000014715 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (393 aa) |
