85 items (Periophthalmus magnuspinnatus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
	ENSPMGP00000000182	Single-stranded DNA binding protein 1. (148 aa)
	ENSPMGP00000000248	Copine family member IX. (551 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (587 aa)
	ENSPMGP00000001054	YJU2 splicing factor homolog. (335 aa)
	ENSPMGP00000001058	SH2 domain-containing protein. (385 aa)
	ENSPMGP00000001519	DNA replication helicase/nuclease 2. (918 aa)
	ENSPMGP00000002444	Si:dkey-102f14.5. (416 aa)
	ENSPMGP00000002767	Dpoe2NT domain-containing protein. (92 aa)
	ENSPMGP00000002778	DNA helicase; Belongs to the MCM family. (809 aa)
	ENSPMGP00000002787	Polymerase (DNA directed), epsilon 2. (325 aa)
	ENSPMGP00000003031	Macro domain-containing protein. (296 aa)
	ENSPMGP00000003957	Replication factor C (activator 1) 2. (342 aa)
	ENSPMGP00000003968	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (248 aa)
	ENSPMGP00000004043	RNase H domain-containing protein. (325 aa)
	ENSPMGP00000004153	Uncharacterized protein. (132 aa)
	ENSPMGP00000004491	Exocyst complex component 8. (686 aa)
	CPNE8	Copine 8. (529 aa)
	ENSPMGP00000004850	Uncharacterized protein. (92 aa)
	ENSPMGP00000005307	Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa)
	ENSPMGP00000005337	Replication protein A2. (280 aa)
	ENSPMGP00000005398	Poly [ADP-ribose] polymerase. (631 aa)
	ENSPMGP00000006219	Uncharacterized protein. (207 aa)
	ENSPMGP00000006454	Calcium binding protein 5a. (176 aa)
	ENSPMGP00000006654	Torsin family 2, member A. (315 aa)
	ENSPMGP00000006737	RAD17 checkpoint clamp loader component. (472 aa)
	ENSPMGP00000007299	Copine VII. (563 aa)
	ENSPMGP00000007386	Macro domain-containing protein. (237 aa)
	ENSPMGP00000007885	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa)
	ENSPMGP00000008736	WRN helicase interacting protein 1. (622 aa)
	ENSPMGP00000009806	Copine VIII. (515 aa)
	ENSPMGP00000010213	Copine Vb. (470 aa)
	ENSPMGP00000010348	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (495 aa)
	ENSPMGP00000010557	Methionine sulfoxide reductase B1b. (383 aa)
	ENSPMGP00000011542	ATPase_AAA_core domain-containing protein. (799 aa)
	ENSPMGP00000012423	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (405 aa)
	ENSPMGP00000012485	Ribonuclease H2, subunit B. (203 aa)
	ENSPMGP00000014113	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (568 aa)
	CPNE3	Copine 3. (512 aa)
	CPNE3-2	Uncharacterized protein. (535 aa)
	ENSPMGP00000015345	Copine III. (515 aa)
	ENSPMGP00000015885	DNA polymerase. (1380 aa)
	ENSPMGP00000016642	Zgc:110269. (304 aa)
	ENSPMGP00000016909	Copine II. (512 aa)
	ENSPMGP00000017107	STN1 subunit of CST complex. (346 aa)
	ENSPMGP00000017421	Copine Va. (486 aa)
	ENSPMGP00000018175	Uncharacterized protein. (405 aa)
	ENSPMGP00000018529	Replication factor C (activator 1) 5. (336 aa)
	ENSPMGP00000019186	DNA polymerase. (1034 aa)
	ENSPMGP00000019989	DNA helicase; Belongs to the MCM family. (809 aa)
	ENSPMGP00000020400	Replication factor C (activator 1) 4. (358 aa)
	ENSPMGP00000020714	Torsin. (331 aa)
	ENSPMGP00000020731	PRKR interacting protein 1. (172 aa)
	ENSPMGP00000021314	Torsin family 4, member Aa. (433 aa)
	ENSPMGP00000021604	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (300 aa)
	ENSPMGP00000022489	Mono-ADP ribosylhydrolase 1. (179 aa)
	ENSPMGP00000022902	DNA helicase; Belongs to the MCM family. (694 aa)
	ENSPMGP00000023263	C2 domain-containing protein. (149 aa)
	ENSPMGP00000023441	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (310 aa)
	ENSPMGP00000023442	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (328 aa)
	ENSPMGP00000023767	Uncharacterized protein. (216 aa)
	ENSPMGP00000024137	Uncharacterized protein. (114 aa)
	ENSPMGP00000025147	DNA helicase; Belongs to the MCM family. (791 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa)
	ENSPMGP00000026390	DNA helicase; Belongs to the MCM family. (890 aa)
	ENSPMGP00000026393	VWFA domain-containing protein. (381 aa)
	ENSPMGP00000026408	Replication protein A3. (122 aa)
	ENSPMGP00000027246	C2 domain-containing protein. (118 aa)
	ENSPMGP00000027398	Torsin family 3, member A. (367 aa)
	ENSPMGP00000027525	Polymerase (DNA-directed), epsilon 4, accessory subunit. (131 aa)
	ENSPMGP00000027896	Si:dkey-28b4.7. (119 aa)
	ENSPMGP00000028148	Chromatin accessibility complex subunit 1. (119 aa)
	ENSPMGP00000028195	Ganglioside induced differentiation associated protein 2. (496 aa)
	ENSPMGP00000028425	Uncharacterized protein. (725 aa)
	ENSPMGP00000028598	Polymerase (DNA directed), delta 2, regulatory subunit. (446 aa)
	ENSPMGP00000029058	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (252 aa)
	ENSPMGP00000029273	Copine IVb. (553 aa)
	ENSPMGP00000029334	Macro domain-containing protein. (300 aa)
	ENSPMGP00000029356	Uncharacterized protein. (168 aa)
	ENSPMGP00000029368	Replication factor C (activator 1) 3. (270 aa)
	ENSPMGP00000029432	Uncharacterized protein. (429 aa)
	ENSPMGP00000029439	Family with sequence similarity 162 member A. (148 aa)
	MCMDC2	Minichromosome maintenance domain containing 2. (654 aa)
	ENSPMGP00000030014	BRCT domain-containing protein. (398 aa)
	ENSPMGP00000030015	RFC1 domain-containing protein. (135 aa)

Your Current Organism:

Periophthalmus magnuspinnatus

NCBI taxonomy Id: 409849
Other names: P. magnuspinnatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPNE3	ENSPMGP00000012485	ENSPMGP00000015339	ENSPMGP00000012485	Copine 3.	Ribonuclease H2, subunit B.	0.686
CPNE3	ENSPMGP00000029058	ENSPMGP00000015339	ENSPMGP00000029058	Copine 3.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.642
CPNE3-2	ENSPMGP00000012485	ENSPMGP00000015341	ENSPMGP00000012485	Uncharacterized protein.	Ribonuclease H2, subunit B.	0.687
CPNE3-2	ENSPMGP00000029058	ENSPMGP00000015341	ENSPMGP00000029058	Uncharacterized protein.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.645
CPNE8	ENSPMGP00000012485	ENSPMGP00000004844	ENSPMGP00000012485	Copine 8.	Ribonuclease H2, subunit B.	0.687
CPNE8	ENSPMGP00000029058	ENSPMGP00000004844	ENSPMGP00000029058	Copine 8.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.645
ENSPMGP00000000182	ENSPMGP00000001519	ENSPMGP00000000182	ENSPMGP00000001519	Single-stranded DNA binding protein 1.	DNA replication helicase/nuclease 2.	0.629
ENSPMGP00000000182	ENSPMGP00000002778	ENSPMGP00000000182	ENSPMGP00000002778	Single-stranded DNA binding protein 1.	DNA helicase; Belongs to the MCM family.	0.465
ENSPMGP00000000182	ENSPMGP00000003957	ENSPMGP00000000182	ENSPMGP00000003957	Single-stranded DNA binding protein 1.	Replication factor C (activator 1) 2.	0.513
ENSPMGP00000000182	ENSPMGP00000003968	ENSPMGP00000000182	ENSPMGP00000003968	Single-stranded DNA binding protein 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.710
ENSPMGP00000000182	ENSPMGP00000004043	ENSPMGP00000000182	ENSPMGP00000004043	Single-stranded DNA binding protein 1.	RNase H domain-containing protein.	0.814
ENSPMGP00000000182	ENSPMGP00000004153	ENSPMGP00000000182	ENSPMGP00000004153	Single-stranded DNA binding protein 1.	Uncharacterized protein.	0.814
ENSPMGP00000000182	ENSPMGP00000005337	ENSPMGP00000000182	ENSPMGP00000005337	Single-stranded DNA binding protein 1.	Replication protein A2.	0.489
ENSPMGP00000000182	ENSPMGP00000006737	ENSPMGP00000000182	ENSPMGP00000006737	Single-stranded DNA binding protein 1.	RAD17 checkpoint clamp loader component.	0.440
ENSPMGP00000000182	ENSPMGP00000010557	ENSPMGP00000000182	ENSPMGP00000010557	Single-stranded DNA binding protein 1.	Methionine sulfoxide reductase B1b.	0.605
ENSPMGP00000000182	ENSPMGP00000014113	ENSPMGP00000000182	ENSPMGP00000014113	Single-stranded DNA binding protein 1.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.605
ENSPMGP00000000182	ENSPMGP00000017107	ENSPMGP00000000182	ENSPMGP00000017107	Single-stranded DNA binding protein 1.	STN1 subunit of CST complex.	0.460
ENSPMGP00000000182	ENSPMGP00000018529	ENSPMGP00000000182	ENSPMGP00000018529	Single-stranded DNA binding protein 1.	Replication factor C (activator 1) 5.	0.463
ENSPMGP00000000182	ENSPMGP00000020400	ENSPMGP00000000182	ENSPMGP00000020400	Single-stranded DNA binding protein 1.	Replication factor C (activator 1) 4.	0.502
ENSPMGP00000000182	ENSPMGP00000021604	ENSPMGP00000000182	ENSPMGP00000021604	Single-stranded DNA binding protein 1.	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.828