(73 nodes) Ferroptosis network (Periophthalmus magnuspinnatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPMGP00000014854	Acyl-CoA synthetase long chain family member 2. (669 aa)
	ENSPMGP00000014282	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (360 aa)
	ENSPMGP00000013080	XK-related protein. (442 aa)
	HMOX1	Heme oxygenase 1. (271 aa)
	ENSPMGP00000012640	AMP-binding domain-containing protein. (317 aa)
	ENSPMGP00000012344	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (669 aa)
	ENSPMGP00000012264	Transferrin receptor 1a. (386 aa)
	ENSPMGP00000009904	Spermidine/spermine N1-acetyltransferase family member 2a. (171 aa)
	ENSPMGP00000009835	Uncharacterized protein. (181 aa)
	ENSPMGP00000008569	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (185 aa)
	ENSPMGP00000007871	NADPH oxidase 1. (509 aa)
	ENSPMGP00000007868	XK-related protein. (491 aa)
	ENSPMGP00000007415	Spermidine/spermine N1-acetyltransferase 1. (179 aa)
	ENSPMGP00000007090	Voltage-dependent anion channel 2. (283 aa)
	ENSPMGP00000006750	STEAP family member 3, metalloreductase. (498 aa)
	ENSPMGP00000006310	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (174 aa)
	ENSPMGP00000005583	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (658 aa)
	ENSPMGP00000005214	Poly(rC) binding protein 2. (313 aa)
	ENSPMGP00000004464	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (94 aa)
	VDAC2	Voltage dependent anion channel 2. (283 aa)
	PCBP2	Poly(rC) binding protein 2. (294 aa)
	FTH1	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (221 aa)
	ENSPMGP00000029030	Glutamate-cysteine ligase, catalytic subunit. (630 aa)
	ENSPMGP00000028234	Uncharacterized protein. (431 aa)
	ENSPMGP00000027939	KH domain-containing protein. (199 aa)
	ENSPMGP00000027737	Uncharacterized protein. (348 aa)
	ENSPMGP00000027624	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (320 aa)
	ENSPMGP00000027506	Glutamate-cysteine ligase, modifier subunit. (271 aa)
	ENSPMGP00000026760	Zgc:110045. (432 aa)
	ENSPMGP00000026756	Solute carrier family 3 member 2a. (508 aa)
	ENSPMGP00000026600	AMP-binding domain-containing protein. (355 aa)
	ENSPMGP00000025613	Glutathione synthetase. (482 aa)
	ENSPMGP00000025582	Cytochrome b-245, beta polypeptide (chronic granulomatous disease). (543 aa)
	STEAP3	Uncharacterized protein. (501 aa)
	ENSPMGP00000024892	Solute carrier family 39 member 8. (414 aa)
	ENSPMGP00000024794	Glutathione synthetase. (412 aa)
	SLC11A2	Solute carrier family 11 member 2. (521 aa)
	ENSPMGP00000023583	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ENSPMGP00000023162	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (271 aa)
	ENSPMGP00000022777	Voltage-dependent anion channel 3. (266 aa)
	ENSPMGP00000022752	Uncharacterized protein. (210 aa)
	ENSPMGP00000022695	Ceruloplasmin; Belongs to the multicopper oxidase family. (1067 aa)
	ENSPMGP00000022497	Uncharacterized protein. (519 aa)
	ENSPMGP00000000067	Poly(rC) binding protein 4. (404 aa)
	ENSPMGP00000000388	AMP-binding domain-containing protein. (269 aa)
	ENSPMGP00000000513	Uncharacterized protein. (944 aa)
	ENSPMGP00000000716	Acyl-CoA synthetase long chain family member 4a. (712 aa)
	ENSPMGP00000000789	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (468 aa)
	ENSPMGP00000001028	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (200 aa)
	ENSPMGP00000001505	Uncharacterized protein. (504 aa)
	ENSPMGP00000001718	Uncharacterized protein. (123 aa)
	ENSPMGP00000002425	Si:ch73-352p4.8. (481 aa)
	ENSPMGP00000003243	AMP-binding domain-containing protein. (695 aa)
	ENSPMGP00000003692	Spermidine/spermine N1-acetyltransferase family member 2b. (173 aa)
	ENSPMGP00000003795	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (158 aa)
	ENSPMGP00000022373	Solute carrier family 39 member 14. (482 aa)
	ENSPMGP00000022372	Microtubule-associated protein 1 light chain 3 gamma, like. (123 aa)
	ENSPMGP00000021842	Microtubule-associated protein 1 light chain 3 beta. (126 aa)
	ENSPMGP00000021406	Pyroglutamyl-peptidase I. (229 aa)
	ENSPMGP00000021316	Zgc:56235. (281 aa)
	ENSPMGP00000019846	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (687 aa)
	ENSPMGP00000018338	Transferrin receptor 1b. (646 aa)
	ENSPMGP00000018273	Acyl-CoA synthetase long chain family member 3b. (707 aa)
	ENSPMGP00000017884	Acyl-CoA synthetase long chain family member 5. (591 aa)
	ENSPMGP00000017681	STEAP family member 2, metalloreductase. (504 aa)
	ENSPMGP00000017533	Uncharacterized protein. (175 aa)
	ENSPMGP00000017297	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (671 aa)
	ENSPMGP00000016034	Aamy domain-containing protein. (499 aa)
	ENSPMGP00000015464	Solute carrier family 7 member 11. (491 aa)
	ENSPMGP00000015114	Acyl-CoA synthetase long chain family member 1a. (435 aa)
	ENSPMGP00000015110	Acyl-CoA synthetase long chain family member 1a. (268 aa)
	ENSPMGP00000015048	Microtubule-associated protein 1 light chain 3 alpha. (121 aa)
	ENSPMGP00000015015	Microtubule-associated protein 1 light chain 3 gamma. (167 aa)

Your Current Organism:

Periophthalmus magnuspinnatus

NCBI taxonomy Id: 409849
Other names: P. magnuspinnatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPMGP00000000388	ENSPMGP00000000716	ENSPMGP00000000388	ENSPMGP00000000716	AMP-binding domain-containing protein.	Acyl-CoA synthetase long chain family member 4a.	0.615
ENSPMGP00000000388	ENSPMGP00000003243	ENSPMGP00000000388	ENSPMGP00000003243	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.619
ENSPMGP00000000388	ENSPMGP00000012640	ENSPMGP00000000388	ENSPMGP00000012640	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.924
ENSPMGP00000000388	ENSPMGP00000015114	ENSPMGP00000000388	ENSPMGP00000015114	AMP-binding domain-containing protein.	Acyl-CoA synthetase long chain family member 1a.	0.949
ENSPMGP00000000388	ENSPMGP00000018273	ENSPMGP00000000388	ENSPMGP00000018273	AMP-binding domain-containing protein.	Acyl-CoA synthetase long chain family member 3b.	0.614
ENSPMGP00000000388	ENSPMGP00000026600	ENSPMGP00000000388	ENSPMGP00000026600	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.862
ENSPMGP00000000388	ENSPMGP00000027624	ENSPMGP00000000388	ENSPMGP00000027624	AMP-binding domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.766
ENSPMGP00000000716	ENSPMGP00000000388	ENSPMGP00000000716	ENSPMGP00000000388	Acyl-CoA synthetase long chain family member 4a.	AMP-binding domain-containing protein.	0.615
ENSPMGP00000000716	ENSPMGP00000003243	ENSPMGP00000000716	ENSPMGP00000003243	Acyl-CoA synthetase long chain family member 4a.	AMP-binding domain-containing protein.	0.824
ENSPMGP00000000716	ENSPMGP00000012344	ENSPMGP00000000716	ENSPMGP00000012344	Acyl-CoA synthetase long chain family member 4a.	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.	0.462
ENSPMGP00000000716	ENSPMGP00000012640	ENSPMGP00000000716	ENSPMGP00000012640	Acyl-CoA synthetase long chain family member 4a.	AMP-binding domain-containing protein.	0.864
ENSPMGP00000000716	ENSPMGP00000014854	ENSPMGP00000000716	ENSPMGP00000014854	Acyl-CoA synthetase long chain family member 4a.	Acyl-CoA synthetase long chain family member 2.	0.863
ENSPMGP00000000716	ENSPMGP00000015110	ENSPMGP00000000716	ENSPMGP00000015110	Acyl-CoA synthetase long chain family member 4a.	Acyl-CoA synthetase long chain family member 1a.	0.849
ENSPMGP00000000716	ENSPMGP00000015114	ENSPMGP00000000716	ENSPMGP00000015114	Acyl-CoA synthetase long chain family member 4a.	Acyl-CoA synthetase long chain family member 1a.	0.863
ENSPMGP00000000716	ENSPMGP00000017297	ENSPMGP00000000716	ENSPMGP00000017297	Acyl-CoA synthetase long chain family member 4a.	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.	0.462
ENSPMGP00000000716	ENSPMGP00000017884	ENSPMGP00000000716	ENSPMGP00000017884	Acyl-CoA synthetase long chain family member 4a.	Acyl-CoA synthetase long chain family member 5.	0.862
ENSPMGP00000000716	ENSPMGP00000018273	ENSPMGP00000000716	ENSPMGP00000018273	Acyl-CoA synthetase long chain family member 4a.	Acyl-CoA synthetase long chain family member 3b.	0.823
ENSPMGP00000000716	ENSPMGP00000019846	ENSPMGP00000000716	ENSPMGP00000019846	Acyl-CoA synthetase long chain family member 4a.	Serotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.	0.462
ENSPMGP00000000716	ENSPMGP00000026600	ENSPMGP00000000716	ENSPMGP00000026600	Acyl-CoA synthetase long chain family member 4a.	AMP-binding domain-containing protein.	0.870
ENSPMGP00000000716	ENSPMGP00000027624	ENSPMGP00000000716	ENSPMGP00000027624	Acyl-CoA synthetase long chain family member 4a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.735