STRINGSTRING
A0A2I2EXT2 A0A2I2EXT2 A0A2I2EYG2 A0A2I2EYG2 A0A2I2EZ43 A0A2I2EZ43 A0A2I2EZT8 A0A2I2EZT8 A0A2I2F2D2 A0A2I2F2D2 A0A2I2F4D4 A0A2I2F4D4 A0A2I2F6L2 A0A2I2F6L2 A0A2I2F770 A0A2I2F770 A0A2I2F7N9 A0A2I2F7N9 A0A2I2F8J7 A0A2I2F8J7 A0A2I2FAI6 A0A2I2FAI6 A0A2I2FAQ8 A0A2I2FAQ8 A0A2I2FAU2 A0A2I2FAU2 A0A2I2FBU1 A0A2I2FBU1 A0A2I2FCU6 A0A2I2FCU6 A0A2I2FCV0 A0A2I2FCV0 A0A2I2FDS4 A0A2I2FDS4 A0A2I2FDT9 A0A2I2FDT9 A0A2I2FE84 A0A2I2FE84 A0A2I2FEA8 A0A2I2FEA8 A0A2I2FH61 A0A2I2FH61 A0A2I2FKG3 A0A2I2FKG3 A0A2I2FL09 A0A2I2FL09 A0A2I2FLK5 A0A2I2FLK5 A0A2I2FN08 A0A2I2FN08 A0A2I2FPE1 A0A2I2FPE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A2I2EXT2Putative exonuclease. (733 aa)
A0A2I2EYG2DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
A0A2I2EZ43Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (783 aa)
A0A2I2EZT8RPA_C domain-containing protein. (287 aa)
A0A2I2F2D2Rad51 domain-containing protein. (407 aa)
A0A2I2F4D4Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (601 aa)
A0A2I2F6L2P-loop containing nucleoside triphosphate hydrolase protein. (375 aa)
A0A2I2F770RECA_2 domain-containing protein. (887 aa)
A0A2I2F7N9Ribonuclease H-like protein. (299 aa)
A0A2I2F8J7UVSB PI-3 kinase; Belongs to the PI3/PI4-kinase family. (2460 aa)
A0A2I2FAI6Uncharacterized protein. (290 aa)
A0A2I2FAQ8Rad51-domain-containing protein; Belongs to the RecA family. (326 aa)
A0A2I2FAU2Rad9-domain-containing protein. (553 aa)
A0A2I2FBU1Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2893 aa)
A0A2I2FCU6Exonuclease. (574 aa)
A0A2I2FCV0Putative RecQ-mediated genome instability protein. (244 aa)
A0A2I2FDS4Uncharacterized protein. (492 aa)
A0A2I2FDT9DNA repair protein RAD50, ABC-type ATPase/SMC superfamily. (1301 aa)
A0A2I2FE84ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (560 aa)
A0A2I2FEA8Uncharacterized protein. (608 aa)
A0A2I2FH61DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (347 aa)
A0A2I2FKG3Checkpoint protein; Belongs to the HUS1 family. (339 aa)
A0A2I2FL09RecQ family helicase MusN. (1541 aa)
A0A2I2FLK5Uncharacterized protein. (1088 aa)
A0A2I2FN08Uncharacterized protein. (383 aa)
A0A2I2FPE1Uncharacterized protein. (518 aa)
Your Current Organism:
Aspergillus candidus
NCBI taxonomy Id: 41067
Other names: A. candidus, CBS 566.65
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