(43 nodes) RNA polymerase II, holoenzyme network (Aspergillus candidus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2I2F2H0	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (300 aa)
	A0A2I2F2D5	Bromodomain associated domain protein. (361 aa)
	A0A2I2F276	Protein prenylyltransferase. (1640 aa)
	A0A2I2F1V1	Leo1-like protein-domain-containing protein. (459 aa)
	A0A2I2F1T4	WD domain protein. (400 aa)
	A0A2I2F183	Uncharacterized protein. (1264 aa)
	A0A2I2F101	Uncharacterized protein. (374 aa)
	A0A2I2F0Z7	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (111 aa)
	A0A2I2F0R1	CDC73-domain-containing protein. (468 aa)
	A0A2I2EZY5	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (128 aa)
	A0A2I2EZI2	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (456 aa)
	A0A2I2EY61	RNA polymerase II transcription factor subunit 1. (636 aa)
	A0A2I2EY10	TAFII55 protein conserved region-domain-containing protein. (486 aa)
	A0A2I2EY00	Bromodomain-containing protein. (216 aa)
	A0A2I2F3R5	Transcription factor TFIIH complex subunit Tfb5-domain-containing protein. (112 aa)
	A0A2I2F3S7	Transcription factor IIA, alpha/beta subunit. (436 aa)
	A0A2I2F3U6	Transcription initiation factor IID, 31kD subunit-domain-containing protein. (319 aa)
	A0A2I2F4A8	DUF4211 domain-containing protein. (623 aa)
	A0A2I2F5I3	TFIID-18kDa-domain-containing protein. (301 aa)
	A0A2I2F6F5	DNA-directed RNA polymerase I, II, and III subunit Rpb6. (158 aa)
	A0A2I2F7U1	RBP11-like subunits of RNA polymerase. (128 aa)
	A0A2I2F7V4	Kinase-like domain-containing protein; Belongs to the protein kinase superfamily. (407 aa)
	A0A2I2F948	Transcription initiation factor IIF, beta subunit. (373 aa)
	A0A2I2F9H8	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (479 aa)
	A0A2I2FAR1	Uncharacterized protein. (272 aa)
	A0A2I2FDV0	Putative cyclin Ccl1; Belongs to the cyclin family. (433 aa)
	A0A2I2FFA5	Transcription initiation factor TFIID subunit A-domain-containing protein. (626 aa)
	A0A2I2FFE5	Uncharacterized protein. (471 aa)
	A0A2I2FG40	Putative transcription factor TFIID complex 145 kDa subunit. (1205 aa)
	A0A2I2FGI3	Rap30/74 interaction domain-containing protein. (710 aa)
	A0A2I2FGV8	CDK-activating kinase assembly factor MAT1. (357 aa)
	A0A2I2FHU7	DNA-directed RNA polymerase. (342 aa)
	A0A2I2FJF1	Uncharacterized protein. (608 aa)
	A0A2I2FK17	RNA polymerase II transcription elongation factor Rtf1p. (599 aa)
	A0A2I2FLG9	WD40 repeat-like protein. (743 aa)
	A0A2I2FLZ4	Transcription factor TFIIE complex alpha subunit. (452 aa)
	A0A2I2FM50	Uncharacterized protein. (430 aa)
	A0A2I2FNA1	TFIIH subunit Tfb4/p34. (391 aa)
	A0A2I2FNA8	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (281 aa)
	A0A2I2FNX5	DNA repair helicase RAD25. (825 aa)
	A0A2I2FP20	Transcription initiation factor TFIID complex subunit. (445 aa)
	A0A2I2FP27	HTAFII28-like protein conserved region-domain-containing protein. (364 aa)
	A0A2I2FPD6	DNA directed RNA polymerase. (75 aa)

Your Current Organism:

Aspergillus candidus

NCBI taxonomy Id: 41067
Other names: A. candidus, CBS 566.65

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2I2EY00	A0A2I2EY10	Bromodomain-containing protein.	TAFII55 protein conserved region-domain-containing protein.	0.937
A0A2I2EY00	A0A2I2F183	Bromodomain-containing protein.	Uncharacterized protein.	0.937
A0A2I2EY00	A0A2I2F2D5	Bromodomain-containing protein.	Bromodomain associated domain protein.	0.946
A0A2I2EY00	A0A2I2F3U6	Bromodomain-containing protein.	Transcription initiation factor IID, 31kD subunit-domain-containing protein.	0.759
A0A2I2EY00	A0A2I2F4A8	Bromodomain-containing protein.	DUF4211 domain-containing protein.	0.659
A0A2I2EY00	A0A2I2F5I3	Bromodomain-containing protein.	TFIID-18kDa-domain-containing protein.	0.766
A0A2I2EY00	A0A2I2FFA5	Bromodomain-containing protein.	Transcription initiation factor TFIID subunit A-domain-containing protein.	0.937
A0A2I2EY00	A0A2I2FG40	Bromodomain-containing protein.	Putative transcription factor TFIID complex 145 kDa subunit.	0.937
A0A2I2EY00	A0A2I2FLG9	Bromodomain-containing protein.	WD40 repeat-like protein.	0.937
A0A2I2EY00	A0A2I2FNA8	Bromodomain-containing protein.	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...]	0.937
A0A2I2EY00	A0A2I2FP20	Bromodomain-containing protein.	Transcription initiation factor TFIID complex subunit.	0.937
A0A2I2EY00	A0A2I2FP27	Bromodomain-containing protein.	HTAFII28-like protein conserved region-domain-containing protein.	0.772
A0A2I2EY10	A0A2I2EY00	TAFII55 protein conserved region-domain-containing protein.	Bromodomain-containing protein.	0.937
A0A2I2EY10	A0A2I2EY61	TAFII55 protein conserved region-domain-containing protein.	RNA polymerase II transcription factor subunit 1.	0.842
A0A2I2EY10	A0A2I2EZI2	TAFII55 protein conserved region-domain-containing protein.	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family.	0.823
A0A2I2EY10	A0A2I2EZY5	TAFII55 protein conserved region-domain-containing protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.842
A0A2I2EY10	A0A2I2F0Z7	TAFII55 protein conserved region-domain-containing protein.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.814
A0A2I2EY10	A0A2I2F101	TAFII55 protein conserved region-domain-containing protein.	Uncharacterized protein.	0.814
A0A2I2EY10	A0A2I2F183	TAFII55 protein conserved region-domain-containing protein.	Uncharacterized protein.	0.999
A0A2I2EY10	A0A2I2F2D5	TAFII55 protein conserved region-domain-containing protein.	Bromodomain associated domain protein.	0.991