STRINGSTRING
metF metF EDR48543.1 EDR48543.1 EDR48544.1 EDR48544.1 asnA asnA EDR48466.1 EDR48466.1 dapF dapF dapL dapL EDR48039.1 EDR48039.1 EDR48040.1 EDR48040.1 dapB dapB dapA dapA cysE cysE ilvE ilvE EDR47759.1 EDR47759.1 EDR47500.1 EDR47500.1 EDR47564.1 EDR47564.1 EDR46953.1 EDR46953.1 EDR46998.1 EDR46998.1 EDR47081.1 EDR47081.1 asd asd luxS luxS metA metA thrH thrH thrC thrC cysK cysK dapF-2 dapF-2 mtnN mtnN EDR46362.1 EDR46362.1 EDR46372.1 EDR46372.1 EDR45479.1 EDR45479.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
metFKEGG: mxa:MXAN_3039 1.4e-68 metF; 5,10-methylenetetrahydrofolate reductase; COG: COG0685 5,10-methylenetetrahydrofolate reductase; Psort location: Cytoplasmic, score: 8.87. (293 aa)
EDR48543.1Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: ctc:CTC01807 5.7e-26 putative 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; COG: NOG21937 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (214 aa)
EDR48544.1KEGG: ctc:CTC01806 6.6e-199 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; COG: COG1410 Methionine synthase I, cobalamin-binding domain; Psort location: Cytoplasmic, score: 8.87. (801 aa)
asnAAspartate--ammonia ligase; KEGG: lsl:LSL_1033 3.7e-134 asnA; aspartate--ammonia ligase K01914; COG: COG2502 Asparagine synthetase A; Psort location: Cytoplasmic, score: 10.00. (335 aa)
EDR48466.1Pyridoxal-dependent decarboxylase, C-terminal sheet domain protein; KEGG: rso:RS00881 3.3e-30 RSp0424; probable diaminopimelate decarboxylase protein K01586; COG: COG0019 Diaminopimelate decarboxylase; Psort location: Cytoplasmic, score: 8.87. (408 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (288 aa)
dapLLL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (404 aa)
EDR48039.1KEGG: chy:CHY_1909 7.1e-115 aspartate kinase, monofunctional class K00928; COG: COG0527 Aspartokinases; Belongs to the aspartokinase family. (402 aa)
EDR48040.1KEGG: swo:Swol_1319 6.6e-80 homoserine dehydrogenase K00003; COG: COG0460 Homoserine dehydrogenase; Psort location: Cytoplasmic, score: 8.87. (406 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (252 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa)
cysEKEGG: chy:CHY_2339 6.4e-66 cysE; serine acetyltransferase K00640; COG: COG1045 Serine acetyltransferase; Psort location: Cytoplasmic, score: 9.98. (276 aa)
ilvEKEGG: cac:CAC1479 4.6e-159 ilvE; branched-chain-amino-acid transaminase (ilvE) K00826; COG: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Psort location: Cytoplasmic, score: 8.87. (341 aa)
EDR47759.1KEGG: chy:CHY_1912 3.5e-129 hom; homoserine dehydrogenase K00003; COG: COG0460 Homoserine dehydrogenase; Psort location: Cytoplasmic, score: 8.87. (430 aa)
EDR47500.1Diaminopimelate dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (328 aa)
EDR47564.1Putative dipeptidase; KEGG: tte:TTE1746 5.7e-81 argE2; acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase and related deacylases K01439; COG: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases; Psort location: Cytoplasmic, score: 8.87. (450 aa)
EDR46953.1KEGG: spn:SP_1978 2.1e-145 diaminopimelate decarboxylase K01586; COG: COG0019 Diaminopimelate decarboxylase; Psort location: Cytoplasmic, score: 8.87. (423 aa)
EDR46998.1O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; KEGG: bth:BT1923 1.5e-176 O-acetylhomoserine (thiol)-lyase K01740; COG: COG2873 O-acetylhomoserine sulfhydrylase; Psort location: Cytoplasmic, score: 9.98. (426 aa)
EDR47081.1Aspartate kinase; KEGG: ctc:CTC02356 2.7e-129 aspartate kinase K00928; COG: COG0527 Aspartokinases; Psort location: Cytoplasmic, score: 8.87; Belongs to the aspartokinase family. (461 aa)
asdKEGG: lsl:LSL_0313 4.1e-142 asd; aspartate-semialdehyde dehydrogenase K00133; COG: COG0136 Aspartate-semialdehyde dehydrogenase; Psort location: Cytoplasmic, score: 8.87. (361 aa)
luxSS-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (159 aa)
metAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (322 aa)
thrHKEGG: hch:HCH_02661 1.1e-54 thrH; phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein K01079; COG: COG0560 Phosphoserine phosphatase; Psort location: Cytoplasmic, score: 8.87. (209 aa)
thrCThreonine synthase; KEGG: cac:CAC0999 6.3e-162 thrC; threonine synthase K01733; COG: COG0498 Threonine synthase; Psort location: Cytoplasmic, score: 8.87. (509 aa)
cysKCysteine synthase A; KEGG: chy:CHY_0808 1.1e-109 cysK; cysteine synthase A K01738; COG: COG0031 Cysteine synthase; Psort location: Cytoplasmic, score: 8.87; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa)
dapF-2Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (285 aa)
mtnNMTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa)
EDR46362.1Methionine synthase, vitamin-B12 independent; KEGG: lsl:LSL_0129 6.8e-94 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score: 8.87. (371 aa)
EDR46372.1Methionine synthase, vitamin-B12 independent; KEGG: lsl:LSL_0129 2.7e-90 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score: 8.87. (372 aa)
EDR45479.1O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; KEGG: bth:BT2387 5.7e-168 O-acetylhomoserine (thiol)-lyase K01740; COG: COG2873 O-acetylhomoserine sulfhydrylase; Psort location: Cytoplasmic, score: 9.98. (475 aa)
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.