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EDR48550.1 EDR48550.1 ldh ldh EDR48332.1 EDR48332.1 EDR48333.1 EDR48333.1 EDR48334.1 EDR48334.1 EDR48335.1 EDR48335.1 EDR48336.1 EDR48336.1 glnA glnA EDR48354.1 EDR48354.1 sdhA sdhA sdhB sdhB EDR48173.1 EDR48173.1 ilvC ilvC ilvN ilvN EDR47918.1 EDR47918.1 ilvB ilvB ilvD ilvD leuB leuB EDR47700.1 EDR47700.1 fucO fucO ilvN-2 ilvN-2 ilvB-2 ilvB-2 EDR47504.1 EDR47504.1 EDR47539.1 EDR47539.1 EDR47540.1 EDR47540.1 EDR47566.1 EDR47566.1 glnA-2 glnA-2 EDR47352.1 EDR47352.1 EDR47355.1 EDR47355.1 EDR47356.1 EDR47356.1 EDR47360.1 EDR47360.1 EDR47361.1 EDR47361.1 EDR47362.1 EDR47362.1 pyk pyk EDR46957.1 EDR46957.1 etfA etfA pta pta ackA ackA ilvA ilvA EDR46989.1 EDR46989.1 EDR47002.1 EDR47002.1 EDR47003.1 EDR47003.1 gltA gltA pflB pflB pflA pflA leuA leuA EDR47244.1 EDR47244.1 EDR46532.1 EDR46532.1 EDR46533.1 EDR46533.1 EDR46534.1 EDR46534.1 cobB-2 cobB-2 pckA pckA EDR46579.1 EDR46579.1 EDR46625.1 EDR46625.1 EDR45652.1 EDR45652.1 EDR45683.1 EDR45683.1 EDR45684.1 EDR45684.1 leuD leuD leuC leuC EDR45778.1 EDR45778.1 ppdK ppdK EDR45799.1 EDR45799.1 nifJ nifJ EDR45865.1 EDR45865.1 EDR46214.1 EDR46214.1 EDR46411.1 EDR46411.1 EDR46507.1 EDR46507.1 EDR46508.1 EDR46508.1 EDR45358.1 EDR45358.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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EDR48550.1Hypothetical protein; KEGG: ctc:CTC00937 1.2e-14 pyruvate formate-lyase K04069; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: Cytoplasmic, score: 8.87. (144 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (314 aa)
EDR48332.12-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; KEGG: cno:NT01CX_0147 5.6e-67 porG; pyruvate synthase subunit PorC K00168; COG: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit; Psort location: Cytoplasmic, score: 8.87. (190 aa)
EDR48333.12-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; KEGG: cno:NT01CX_0146 4.8e-22 porD; pyruvate synthase subunit PorD K00168; COG: COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit; Psort location: Cytoplasmic, score: 8.87. (100 aa)
EDR48334.1Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain protein; KEGG: ctc:CTC02526 2.0e-126 porA; pyruvate synthase subunit porA K00169; COG: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit; Psort location: Cytoplasmic, score: 8.87. (394 aa)
EDR48335.1Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; KEGG: ctc:CTC02525 4.2e-101 porB; pyruvate synthase subunit porB K00170; COG: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; Psort location: Cytoplasmic, score: 8.87. (311 aa)
EDR48336.1Propanediol utilization protein PduL; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (214 aa)
glnAKEGG: chy:CHY_0704 5.6e-154 glnA1; glutamine synthetase K01915; COG: COG0174 Glutamine synthetase; Psort location: Cytoplasmic, score: 9.98. (444 aa)
EDR48354.1Rep protein; COG: NOG14934 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (277 aa)
sdhAKEGG: gka:GK2672 5.6e-83 sdhA; succinate dehydrogenase (flavoprotein subunit) K00239; COG: COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Psort location: Cytoplasmic, score: 9.36. (472 aa)
sdhBKEGG: sha:SH1812 1.0e-35 sdhB; succinate dehydrogenase iron-sulfur protein subunit K00240; COG: COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. (236 aa)
EDR48173.1Rep protein; COG: NOG14934 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (277 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
ilvNKEGG: chy:CHY_1594 4.3e-37 ilvN2; acetolactate synthase, small subunit K01653; COG: COG0440 Acetolactate synthase, small (regulatory) subunit; Psort location: Cytoplasmic, score: 8.87. (165 aa)
EDR47918.1KEGG: dra:DRA0143 1.2e-55 3-hydroxyacyl-CoA dehydrogenase, putative K00022; COG: COG1250 3-hydroxyacyl-CoA dehydrogenase. (238 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 4.9e-171 ilvB; acetolactate synthase large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: Cytoplasmic, score: 8.87. (558 aa)
ilvDKEGG: chy:CHY_0516 1.4e-198 ilvD; dihydroxy-acid dehydratase K01687; COG: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Psort location: Cytoplasmic, score: 8.87; Belongs to the IlvD/Edd family. (557 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (360 aa)
EDR47700.1Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; KEGG: lsl:LSL_1297 1.5e-192 gdhA; NADP-specific glutamate dehydrogenase K00262; COG: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Psort location: Cytoplasmic, score: 9.98; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa)
fucOLactaldehyde reductase; KEGG: cpf:CPF_1046 2.0e-156 fucO; lactaldehyde reductase K00048; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: Cytoplasmic, score: 9.98. (381 aa)
ilvN-2KEGG: noc:Noc_2519 6.8e-30 acetolactate synthase, small subunit K01653; COG: COG0440 Acetolactate synthase, small (regulatory) subunit; Psort location: Cytoplasmic, score: 8.87. (172 aa)
ilvB-2Acetolactate synthase, large subunit, biosynthetic type; KEGG: mma:MM0670 1.1e-155 acetolactate synthase large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: Cytoplasmic, score: 8.87. (575 aa)
EDR47504.1KEGG: lla:L67186 3.9e-137 gltA; citrate synthase K01647; COG: COG0372 Citrate synthase; Psort location: Cytoplasmic, score: 9.98. (461 aa)
EDR47539.1Putative formate C-acetyltransferase; KEGG: cno:NT01CX_0385 3.1e-144 pyruvate formate-lyase K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: Cytoplasmic, score: 9.98. (803 aa)
EDR47540.1Glycyl-radical enzyme activating protein family protein; KEGG: cno:NT01CX_0497 3.9e-59 pflC; pyruvate formate-lyase K00538; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: Cytoplasmic, score: 9.98. (302 aa)
EDR47566.1KEGG: ctc:CTC00824 3.1e-169 aspartate ammonia-lyase, aspartase K01744; COG: COG1027 Aspartate ammonia-lyase; Psort location: Cytoplasmic, score: 9.98. (485 aa)
glnA-2Glutamate--ammonia ligase, catalytic domain protein; KEGG: tte:TTE0821 6.4e-240 glnA; Glutamine synthase K01915; COG: COG3968 Uncharacterized protein related to glutamine synthetase; Psort location: Cytoplasmic, score: 9.98. (703 aa)
EDR47352.1Aldehyde dehydrogenase (NAD) family protein; KEGG: cpe:CPE2531 0. adhE; alcohol dehydrogenase / acetaldehyde dehydrogenase K00001:K04072; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: Cytoplasmic, score: 9.98; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (868 aa)
EDR47355.1Hydrogenase, Fe-only; KEGG: mta:Moth_1717 5.5e-147 iron hydrogenase, small subunit K00336; COG: COG4624 Iron only hydrogenase large subunit, C-terminal domain; Psort location: Cytoplasmic, score: 8.87. (577 aa)
EDR47356.1Pyridine nucleotide-disulfide oxidoreductase; KEGG: cte:CT0282 3.9e-82 glutamate synthase (NADPH) small chain K00266; COG: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; Psort location: Cytoplasmic, score: 9.98. (610 aa)
EDR47360.1Pyridine nucleotide-disulfide oxidoreductase; KEGG: cte:CT0282 5.7e-74 glutamate synthase (NADPH) small chain K00266; COG: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; Psort location: Cytoplasmic, score: 9.98. (611 aa)
EDR47361.1Molybdopterin oxidoreductase Fe4S4 domain protein; KEGG: msu:MS0732 7.5e-111 uncharacterized anaerobic dehydrogenase K00123; COG: COG3383 Uncharacterized anaerobic dehydrogenase; Psort location: Cytoplasmic, score: 8.87. (353 aa)
EDR47362.1Molybdopterin oxidoreductase; KEGG: msu:MS0732 3.0e-203 uncharacterized anaerobic dehydrogenase K00123; COG: COG3383 Uncharacterized anaerobic dehydrogenase; Psort location: Cytoplasmic, score: 8.87; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (533 aa)
pykPyruvate kinase; KEGG: tte:TTE1815 2.8e-136 pykF; pyruvate kinase K00873; COG: COG0469 Pyruvate kinase; Psort location: Cytoplasmic, score: 8.87. (478 aa)
EDR46957.1COG: COG2086 Electron transfer flavoprotein, beta subunit; Psort location: Cytoplasmic, score: 8.87. (263 aa)
etfAElectron transfer flavoprotein FAD-binding domain protein; KEGG: fnu:FN1424 7.8e-17 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit; Psort location: Cytoplasmic, score: 8.87. (327 aa)
ptaPhosphate acetyltransferase; KEGG: hhe:HH1309 1.8e-100 pta; phosphotransacetylase K00625; COG: COG0280 Phosphotransacetylase; Psort location: Cytoplasmic, score: 8.87. (334 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa)
ilvAKEGG: fnu:FN1411 1.5e-114 threonine dehydratase K01754; COG: COG1171 Threonine dehydratase. (404 aa)
EDR46989.1Isocitrate dehydrogenase, NADP-dependent; KEGG: tte:TTE0387 7.5e-159 icd; Isocitrate dehydrogenases K00031; COG: COG0538 Isocitrate dehydrogenases; Psort location: Cytoplasmic, score: 8.87; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (399 aa)
EDR47002.1Alcohol dehydrogenase, iron-dependent; KEGG: cpf:CPF_1465 1.4e-143 adh1; NADPH-dependent butanol dehydrogenase K00100; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: Cytoplasmic, score: 9.98. (393 aa)
EDR47003.1ferredoxin--NADP+ reductase, subunit alpha; KEGG: cno:NT01CX_0467 5.6e-106 glutamate synthase, small subunit K00226; COG: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases; Psort location: Cytoplasmic, score: 9.98. (295 aa)
gltAKEGG: cno:NT01CX_0466 6.1e-180 gltA; glutamate synthase (NADPH), homotetrameric K00264; COG: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; Psort location: Cytoplasmic, score: 9.98. (462 aa)
pflBKEGG: bli:BL01863 3.6e-269 hypothetical formate acetyltransferase K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: Cytoplasmic, score: 9.98. (769 aa)
pflAPyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (241 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (665 aa)
EDR47244.1Oxidoreductase, aldo/keto reductase family protein; KEGG: lsl:LSL_0710 1.4e-68 oxidoreductase K00100; COG: COG0656 Aldo/keto reductases, related to diketogulonate reductase; Psort location: Cytoplasmic, score: 8.87. (280 aa)
EDR46532.1KEGG: tma:TM1424 7.2e-35 NADH dehydrogenase I chain E K00334; COG: COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit; Psort location: Cytoplasmic, score: 9.98. (162 aa)
EDR46533.14Fe-4S binding domain protein; KEGG: chy:CHY_0732 2.8e-200 hydB; Fe-hydrogenase, beta subunit K00335; COG: COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit; Psort location: Cytoplasmic, score: 9.98. (625 aa)
EDR46534.1Hydrogenase, Fe-only; KEGG: tte:TTE0894 5.9e-143 nuoG; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) K00336; COG: COG4624 Iron only hydrogenase large subunit, C-terminal domain; Psort location: Cytoplasmic, score: 8.87. (582 aa)
cobB-2Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (240 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (534 aa)
EDR46579.1Formate dehydrogenase accessory protein; Required for formate dehydrogenase (FDH) activity. Belongs to the FdhD family. (270 aa)
EDR46625.14Fe-4S binding domain protein; KEGG: mka:MK0930 4.4e-07 coenzyme F420-reducing hydrogenase, gamma subunit K00439; COG: COG1145 Ferredoxin; Psort location: Cytoplasmic, score: 8.87. (249 aa)
EDR45652.14Fe-4S binding domain protein; KEGG: mja:MJ1167 1.7e-05 fwdG; formylmethanofuran dehydrogenase, subunit G (tungsten) K00205; COG: COG1145 Ferredoxin; Psort location: Cytoplasmic, score: 8.87. (249 aa)
EDR45683.14Fe-4S binding domain protein; KEGG: ecp:ECP_0909 5.9e-24 anaerobic dimethyl sulfoxide reductase, subunit B K07307; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: CytoplasmicMembrane, score: 9.49. (142 aa)
EDR45684.1KEGG: afu:AF1203 7.7e-86 molybdopterin oxidoreductase, molybdopterin binding subunit K00183; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Cytoplasmic, score: 8.87; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (707 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa)
EDR45778.1Putative membrane protein FdrA; KEGG: ape:APE_1072.1 1.2e-11 succinyl-CoA synthetase alpha chain K01902; COG: COG0074 Succinyl-CoA synthetase, alpha subunit; Psort location: Cytoplasmic, score: 8.87. (1003 aa)
ppdKPyruvate, phosphate dikinase; KEGG: tte:TTE0981 0. ppsA2; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase K01006; COG: COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Psort location: Cytoplasmic, score: 9.98; Belongs to the PEP-utilizing enzyme family. (874 aa)
EDR45799.1KEGG: afu:AF1203 1.6e-69 molybdopterin oxidoreductase, molybdopterin binding subunit K00183; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: Cytoplasmic, score: 8.87; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (702 aa)
nifJKEGG: ctc:CTC01741 0. pyruvate-flavodoxin oxidoreductase K03737; COG: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; Psort location: Cytoplasmic, score: 8.87. (1179 aa)
EDR45865.1Malic enzyme, NAD binding domain protein; KEGG: tte:TTE2332 3.2e-126 sfcA; malic enzyme K00027; COG: COG0281 Malic enzyme; Psort location: CytoplasmicMembrane, score: 9.76. (386 aa)
EDR46214.1Aconitase domain protein; KEGG: ecp:ECP_0784 6.2e-242 aconitate hydratase K01680; COG: COG1048 Aconitase A; Psort location: Cytoplasmic, score: 9.98. (759 aa)
EDR46411.1KEGG: cno:NT01CX_0234 3.0e-132 citrate synthase I K01647; COG: COG0372 Citrate synthase; Psort location: Cytoplasmic, score: 9.98. (484 aa)
EDR46507.1Class II glutamine amidotransferase; KEGG: gka:GK1431 0. glutamate synthaselarge subunit K00265; COG: COG0069 Glutamate synthase domain 2; Psort location: Cytoplasmic, score: 8.87. (1512 aa)
EDR46508.1Pyridine nucleotide-disulfide oxidoreductase; KEGG: syn:sll1027 1.5e-144 gltD; NADH-dependent glutamate synthase small subunit K00269; COG: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; Psort location: Cytoplasmic, score: 9.98. (516 aa)
EDR45358.1Aldehyde dehydrogenase (NAD) family protein; KEGG: bca:BCE_1397 3.1e-121 ywdH; aldehyde dehydrogenase K00128; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: Cytoplasmic, score: 9.98. (459 aa)
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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