STRINGSTRING
coaX coaX EDR48274.1 EDR48274.1 EDR48287.1 EDR48287.1 ilvC ilvC ilvN ilvN ilvB ilvB ilvD ilvD ilvE ilvE ilvN-2 ilvN-2 ilvB-2 ilvB-2 EDR47832.1 EDR47832.1 EDR47833.1 EDR47833.1 coaE coaE coaD coaD EDR45599.1 EDR45599.1 EDR45697.1 EDR45697.1 EDR45783.1 EDR45783.1 EDR46140.1 EDR46140.1 EDR46144.1 EDR46144.1 EDR46181.1 EDR46181.1 coaBC coaBC EDR45358.1 EDR45358.1 EDR45446.1 EDR45446.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
coaXPantothenate kinase, type III; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (256 aa)
EDR48274.1Hypothetical protein. (66 aa)
EDR48287.1Lipase/acylhydrolase, GDSL family; KEGG: fra:Francci3_1861 4.7e-09 2-dehydropantoate 2-reductase K00077; COG: COG1893 Ketopantoate reductase. (315 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
ilvNKEGG: chy:CHY_1594 4.3e-37 ilvN2; acetolactate synthase, small subunit K01653; COG: COG0440 Acetolactate synthase, small (regulatory) subunit; Psort location: Cytoplasmic, score: 8.87. (165 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 4.9e-171 ilvB; acetolactate synthase large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: Cytoplasmic, score: 8.87. (558 aa)
ilvDKEGG: chy:CHY_0516 1.4e-198 ilvD; dihydroxy-acid dehydratase K01687; COG: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Psort location: Cytoplasmic, score: 8.87; Belongs to the IlvD/Edd family. (557 aa)
ilvEKEGG: cac:CAC1479 4.6e-159 ilvE; branched-chain-amino-acid transaminase (ilvE) K00826; COG: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Psort location: Cytoplasmic, score: 8.87. (341 aa)
ilvN-2KEGG: noc:Noc_2519 6.8e-30 acetolactate synthase, small subunit K01653; COG: COG0440 Acetolactate synthase, small (regulatory) subunit; Psort location: Cytoplasmic, score: 8.87. (172 aa)
ilvB-2Acetolactate synthase, large subunit, biosynthetic type; KEGG: mma:MM0670 1.1e-155 acetolactate synthase large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: Cytoplasmic, score: 8.87. (575 aa)
EDR47832.1Hypothetical protein; COG: NOG11065 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (909 aa)
EDR47833.1Site-specific recombinase, phage integrase family; COG: NOG11064 non supervised orthologous group. (495 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (196 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa)
EDR45599.1Ketopantoate reductase PanE/ApbA; KEGG: fra:Francci3_1861 3.0e-09 2-dehydropantoate 2-reductase K00077; COG: COG1893 Ketopantoate reductase; Psort location: Cytoplasmic, score: 8.87. (300 aa)
EDR45697.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (305 aa)
EDR45783.1Putative allantoinase; KEGG: chy:CHY_0678 5.4e-69 allB; allantoinase K01466; COG: COG0044 Dihydroorotase and related cyclic amidohydrolases; Psort location: Cytoplasmic, score: 8.87. (469 aa)
EDR46140.1Hypothetical protein; Psort location: Cytoplasmic, score: 8.87. (74 aa)
EDR46144.1Hypothetical protein; Psort location: Cytoplasmic, score: 8.87. (74 aa)
EDR46181.1KEGG: bld:BLi00407 2.9e-15 hypothetical protein K01005; COG: COG2091 Phosphopantetheinyl transferase; Psort location: Cytoplasmic, score: 8.87. (216 aa)
coaBCPhosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (401 aa)
EDR45358.1Aldehyde dehydrogenase (NAD) family protein; KEGG: bca:BCE_1397 3.1e-121 ywdH; aldehyde dehydrogenase K00128; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: Cytoplasmic, score: 9.98. (459 aa)
EDR45446.1Hypothetical protein. (62 aa)
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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