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argB argB EDR48359.1 EDR48359.1 ilvC ilvC ilvN ilvN ilvB ilvB ilvD ilvD leuB leuB EDR48023.1 EDR48023.1 EDR48039.1 EDR48039.1 EDR47680.1 EDR47680.1 ilvE ilvE ilvN-2 ilvN-2 ilvB-2 ilvB-2 EDR47504.1 EDR47504.1 EDR47666.1 EDR47666.1 EDR46989.1 EDR46989.1 EDR47081.1 EDR47081.1 leuA leuA asd asd EDR46813.1 EDR46813.1 leuD leuD leuC leuC EDR45850.1 EDR45850.1 argD argD argJ argJ EDR45885.1 EDR45885.1 argC argC EDR46214.1 EDR46214.1 EDR46233.1 EDR46233.1 EDR46396.1 EDR46396.1 EDR46411.1 EDR46411.1 EDR45445.1 EDR45445.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (307 aa)
EDR48359.1KEGG: bcz:BCZK2533 2.1e-21 acetyltransferase, GNAT family K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: Cytoplasmic, score: 8.87. (143 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
ilvNKEGG: chy:CHY_1594 4.3e-37 ilvN2; acetolactate synthase, small subunit K01653; COG: COG0440 Acetolactate synthase, small (regulatory) subunit; Psort location: Cytoplasmic, score: 8.87. (165 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 4.9e-171 ilvB; acetolactate synthase large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: Cytoplasmic, score: 8.87. (558 aa)
ilvDKEGG: chy:CHY_0516 1.4e-198 ilvD; dihydroxy-acid dehydratase K01687; COG: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Psort location: Cytoplasmic, score: 8.87; Belongs to the IlvD/Edd family. (557 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (360 aa)
EDR48023.1KEGG: bca:BCE_3757 7.1e-12 acetyltransferase, GNAT family, putative K03830; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: Cytoplasmic, score: 8.87. (153 aa)
EDR48039.1KEGG: chy:CHY_1909 7.1e-115 aspartate kinase, monofunctional class K00928; COG: COG0527 Aspartokinases; Belongs to the aspartokinase family. (402 aa)
EDR47680.1KEGG: fnu:FN1462 3.6e-88 transcriptional regulator, GntR family K00375; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: Cytoplasmic, score: 9.98. (465 aa)
ilvEKEGG: cac:CAC1479 4.6e-159 ilvE; branched-chain-amino-acid transaminase (ilvE) K00826; COG: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Psort location: Cytoplasmic, score: 8.87. (341 aa)
ilvN-2KEGG: noc:Noc_2519 6.8e-30 acetolactate synthase, small subunit K01653; COG: COG0440 Acetolactate synthase, small (regulatory) subunit; Psort location: Cytoplasmic, score: 8.87. (172 aa)
ilvB-2Acetolactate synthase, large subunit, biosynthetic type; KEGG: mma:MM0670 1.1e-155 acetolactate synthase large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: Cytoplasmic, score: 8.87. (575 aa)
EDR47504.1KEGG: lla:L67186 3.9e-137 gltA; citrate synthase K01647; COG: COG0372 Citrate synthase; Psort location: Cytoplasmic, score: 9.98. (461 aa)
EDR47666.1Aminotransferase, class I/II; KEGG: pac:PPA1893 2.5e-96 aminotransferase K00811; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: Cytoplasmic, score: 8.87. (428 aa)
EDR46989.1Isocitrate dehydrogenase, NADP-dependent; KEGG: tte:TTE0387 7.5e-159 icd; Isocitrate dehydrogenases K00031; COG: COG0538 Isocitrate dehydrogenases; Psort location: Cytoplasmic, score: 8.87; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (399 aa)
EDR47081.1Aspartate kinase; KEGG: ctc:CTC02356 2.7e-129 aspartate kinase K00928; COG: COG0527 Aspartokinases; Psort location: Cytoplasmic, score: 8.87; Belongs to the aspartokinase family. (461 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (665 aa)
asdKEGG: lsl:LSL_0313 4.1e-142 asd; aspartate-semialdehyde dehydrogenase K00133; COG: COG0136 Aspartate-semialdehyde dehydrogenase; Psort location: Cytoplasmic, score: 8.87. (361 aa)
EDR46813.1UbiC transcription regulator-associated domain protein; KEGG: reh:H16_A3019 3.4e-11 hutC; histidine utilization repressor; COG: COG2188 Transcriptional regulators; Psort location: Cytoplasmic, score: 8.87. (236 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa)
EDR45850.1Aminotransferase, class I/II; KEGG: cac:CAC2832 5.0e-114 PLP-dependent aminotransferase K00811; COG: COG0436 Aspartate/tyrosine/aromatic aminotransferase; Psort location: Cytoplasmic, score: 8.87. (395 aa)
argDAminotransferase, acetylornithine/succinylornithine family; KEGG: cje:Cj0227 1.5e-112 argD; acetylornithine aminotransferase K00818; COG: COG4992 Ornithine/acetylornithine aminotransferase; Psort location: Cytoplasmic, score: 8.87; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (397 aa)
argJGlutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa)
EDR45885.1Acetyltransferase, GNAT family; KEGG: rba:RB7615 9.0e-12 putative acetyltransferase K00680; COG: COG0456 Acetyltransferases; Psort location: Cytoplasmic, score: 8.87. (143 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
EDR46214.1Aconitase domain protein; KEGG: ecp:ECP_0784 6.2e-242 aconitate hydratase K01680; COG: COG1048 Aconitase A; Psort location: Cytoplasmic, score: 9.98. (759 aa)
EDR46233.1KEGG: saa:SAUSA300_2505 6.3e-20 acetyltransferase, GNAT family K00680; COG: NOG18266 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (179 aa)
EDR46396.1Hypothetical protein; COG: NOG32695 non supervised orthologous group. (154 aa)
EDR46411.1KEGG: cno:NT01CX_0234 3.0e-132 citrate synthase I K01647; COG: COG0372 Citrate synthase; Psort location: Cytoplasmic, score: 9.98. (484 aa)
EDR45445.1Hypothetical protein. (113 aa)
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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