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| | EDR48543.1 | Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: ctc:CTC01807 5.7e-26 putative 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; COG: NOG21937 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (214 aa) |
| | EDR48544.1 | KEGG: ctc:CTC01806 6.6e-199 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; COG: COG1410 Methionine synthase I, cobalamin-binding domain; Psort location: Cytoplasmic, score: 8.87. (801 aa) |
| | asnA | Aspartate--ammonia ligase; KEGG: lsl:LSL_1033 3.7e-134 asnA; aspartate--ammonia ligase K01914; COG: COG2502 Asparagine synthetase A; Psort location: Cytoplasmic, score: 10.00. (335 aa) |
| | maf | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (189 aa) |
| | EDR48453.1 | Hypothetical protein; COG: COG3547 Transposase and inactivated derivatives; Psort location: Cytoplasmic, score: 8.87. (193 aa) |
| | glnA | KEGG: chy:CHY_0704 5.6e-154 glnA1; glutamine synthetase K01915; COG: COG0174 Glutamine synthetase; Psort location: Cytoplasmic, score: 9.98. (444 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (288 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (404 aa) |
| | EDR48359.1 | KEGG: bcz:BCZK2533 2.1e-21 acetyltransferase, GNAT family K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: Cytoplasmic, score: 8.87. (143 aa) |
| | argG | KEGG: lma:LmjF23.0260 3.0e-132 argininosuccinate synthase, putative K01940; COG: COG0137 Argininosuccinate synthase; Psort location: Cytoplasmic, score: 8.87; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (408 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (330 aa) |
| | EDR48302.1 | KEGG: cac:CAC0089 3.4e-76 serA; D-3-phosphoglycerate dehydrogenase K00058; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: Cytoplasmic, score: 9.98; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa) |
| | EDR48194.1 | Amidohydrolase; KEGG: fnu:FN1063 2.3e-77 N-acyl-L-amino acid amidohydrolase K01436; COG: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; Psort location: Cytoplasmic, score: 8.87. (399 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | ilvN | KEGG: chy:CHY_1594 4.3e-37 ilvN2; acetolactate synthase, small subunit K01653; COG: COG0440 Acetolactate synthase, small (regulatory) subunit; Psort location: Cytoplasmic, score: 8.87. (165 aa) |
| | EDR47931.1 | Prephenate dehydratase; KEGG: det:DET0461 3.5e-49 tyrA; chorismate mutase / prephenate dehydratase K04093:K04518; COG: COG0077 Prephenate dehydratase; Psort location: Cytoplasmic, score: 9.98. (376 aa) |
| | prs | Ribose-phosphate diphosphokinase; KEGG: cac:CAC0819 9.8e-102 phosphoribosylpyrophosphate synthetase K00948; COG: COG0462 Phosphoribosylpyrophosphate synthetase; Psort location: CytoplasmicMembrane, score: 7.80; Belongs to the ribose-phosphate pyrophosphokinase family. (405 aa) |
| | pdxB | KEGG: bce:BC3248 2.1e-106 D-3-phosphoglycerate dehydrogenase K00058; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: Cytoplasmic, score: 9.98; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (387 aa) |
| | serC | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (360 aa) |
| | ilvB | Acetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 4.9e-171 ilvB; acetolactate synthase large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: Cytoplasmic, score: 8.87. (558 aa) |
| | ilvD | KEGG: chy:CHY_0516 1.4e-198 ilvD; dihydroxy-acid dehydratase K01687; COG: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Psort location: Cytoplasmic, score: 8.87; Belongs to the IlvD/Edd family. (557 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (360 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (367 aa) |
| | EDR48023.1 | KEGG: bca:BCE_3757 7.1e-12 acetyltransferase, GNAT family, putative K03830; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: Cytoplasmic, score: 8.87. (153 aa) |
| | EDR48039.1 | KEGG: chy:CHY_1909 7.1e-115 aspartate kinase, monofunctional class K00928; COG: COG0527 Aspartokinases; Belongs to the aspartokinase family. (402 aa) |
| | EDR48040.1 | KEGG: swo:Swol_1319 6.6e-80 homoserine dehydrogenase K00003; COG: COG0460 Homoserine dehydrogenase; Psort location: Cytoplasmic, score: 8.87. (406 aa) |
| | hisA | KEGG: ath:At2g36230 1.7e-72 F2H17.16; N'-5'-phosphoribosyl-formimino-5-aminoimidazole-4- carboxamide ribonucleotide isomerase K01814; COG: KOG3055 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; Psort location: Cytoplasmic, score: 8.87; Belongs to the HisA/HisF family. (267 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (252 aa) |
| | cysE | KEGG: chy:CHY_2339 6.4e-66 cysE; serine acetyltransferase K00640; COG: COG1045 Serine acetyltransferase; Psort location: Cytoplasmic, score: 9.98. (276 aa) |
| | ilvE | KEGG: cac:CAC1479 4.6e-159 ilvE; branched-chain-amino-acid transaminase (ilvE) K00826; COG: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Psort location: Cytoplasmic, score: 8.87. (341 aa) |
| | ilvN-2 | KEGG: noc:Noc_2519 6.8e-30 acetolactate synthase, small subunit K01653; COG: COG0440 Acetolactate synthase, small (regulatory) subunit; Psort location: Cytoplasmic, score: 8.87. (172 aa) |
| | ilvB-2 | Acetolactate synthase, large subunit, biosynthetic type; KEGG: mma:MM0670 1.1e-155 acetolactate synthase large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: Cytoplasmic, score: 8.87. (575 aa) |
| | EDR47759.1 | KEGG: chy:CHY_1912 3.5e-129 hom; homoserine dehydrogenase K00003; COG: COG0460 Homoserine dehydrogenase; Psort location: Cytoplasmic, score: 8.87. (430 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: chu:CHU_2987 4.8e-100 gapA; glyceraldehyde-3-phosphate dehydrogenase A K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: Cytoplasmic, score: 9.98. (340 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (261 aa) |
| | sdaAB | L-serine dehydratase, iron-sulfur-dependent, beta subunit; KEGG: tte:TTE1008 4.5e-49 sdaA; L-serine deaminase K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87; Belongs to the iron-sulfur dependent L-serine dehydratase family. (223 aa) |
| | sdaAA | KEGG: cno:NT01CX_1254 4.8e-61 sdaAA; L-serine dehydratase, iron-sulfur-dependent, alpha subunit K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87. (289 aa) |
| | EDR47500.1 | Diaminopimelate dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (328 aa) |
| | ksgA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (292 aa) |
| | EDR47504.1 | KEGG: lla:L67186 3.9e-137 gltA; citrate synthase K01647; COG: COG0372 Citrate synthase; Psort location: Cytoplasmic, score: 9.98. (461 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (353 aa) |
| | aroF | 3-deoxy-7-phosphoheptulonate synthase; KEGG: cpe:CPE0694 3.1e-114 phospho-2-dehydro-3-deoxyheptonate aldolase K03856; COG: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Psort location: Cytoplasmic, score: 8.87. (337 aa) |
| | aroK-2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (164 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (422 aa) |
| | EDR47560.1 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.87. (138 aa) |
| | EDR47564.1 | Putative dipeptidase; KEGG: tte:TTE1746 5.7e-81 argE2; acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase and related deacylases K01439; COG: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases; Psort location: Cytoplasmic, score: 8.87. (450 aa) |
| | rpiB | KEGG: sth:STH2337 5.9e-56 ribose 5-phosphate isomerase K01808; COG: COG0698 Ribose 5-phosphate isomerase RpiB; Psort location: Cytoplasmic, score: 8.87. (154 aa) |
| | fba | KEGG: cpf:CPF_1557 1.0e-113 fba; fructose-1,6-bisphosphate aldolase, class II K01624; COG: COG0191 Fructose/tagatose bisphosphate aldolase; Psort location: Cytoplasmic, score: 8.87. (293 aa) |
| | glnA-2 | Glutamate--ammonia ligase, catalytic domain protein; KEGG: tte:TTE0821 6.4e-240 glnA; Glutamine synthase K01915; COG: COG3968 Uncharacterized protein related to glutamine synthetase; Psort location: Cytoplasmic, score: 9.98. (703 aa) |
| | EDR47261.1 | Beta-eliminating lyase; KEGG: cac:CAC3420 3.3e-110 low specificity L-threonine aldolase K01620; COG: COG2008 Threonine aldolase; Psort location: Cytoplasmic, score: 8.87. (347 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (218 aa) |
| | EDR47305.1 | Hypothetical protein; KEGG: ppd:Ppro_1582 1.1e-18 anthranilate synthase component I K01656; COG: COG0147 Anthranilate/para-aminobenzoate synthases component I; Psort location: Cytoplasmic, score: 8.87. (209 aa) |
| | EDR47312.1 | Hypothetical protein; COG: NOG15588 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (83 aa) |
| | EDR46940.1 | Histidinol phosphate phosphatase HisJ family; KEGG: oih:OB0554 1.5e-48 histidinol phosphatase K04486; COG: COG1387 Histidinol phosphatase and related hydrolases of the PHP family; Psort location: Cytoplasmic, score: 8.87. (268 aa) |
| | gap-2 | KEGG: fth:FTH_1121 3.4e-122 gapA; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: Cytoplasmic, score: 9.98. (337 aa) |
| | pgk | Phosphoglycerate kinase; KEGG: ctc:CTC00379 2.2e-152 pgk; phosphoglycerate kinase K00927; COG: COG0126 3-phosphoglycerate kinase; Psort location: Cytoplasmic, score: 9.98. (397 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa) |
| | pyk | Pyruvate kinase; KEGG: tte:TTE1815 2.8e-136 pykF; pyruvate kinase K00873; COG: COG0469 Pyruvate kinase; Psort location: Cytoplasmic, score: 8.87. (478 aa) |
| | EDR46953.1 | KEGG: spn:SP_1978 2.1e-145 diaminopimelate decarboxylase K01586; COG: COG0019 Diaminopimelate decarboxylase; Psort location: Cytoplasmic, score: 8.87. (423 aa) |
| | EDR46962.1 | ACT domain protein; KEGG: nph:NP5006A 9.7e-07 purU; formyltetrahydrofolate deformylase K01433; COG: COG3830 ACT domain-containing protein; Psort location: Cytoplasmic, score: 8.87; Belongs to the UPF0237 family. (90 aa) |
| | ilvA | KEGG: fnu:FN1411 1.5e-114 threonine dehydratase K01754; COG: COG1171 Threonine dehydratase. (404 aa) |
| | EDR46989.1 | Isocitrate dehydrogenase, NADP-dependent; KEGG: tte:TTE0387 7.5e-159 icd; Isocitrate dehydrogenases K00031; COG: COG0538 Isocitrate dehydrogenases; Psort location: Cytoplasmic, score: 8.87; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (399 aa) |
| | rex | CoA binding domain protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (213 aa) |
| | gltA | KEGG: cno:NT01CX_0466 6.1e-180 gltA; glutamate synthase (NADPH), homotetrameric K00264; COG: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; Psort location: Cytoplasmic, score: 9.98. (462 aa) |
| | EDR47081.1 | Aspartate kinase; KEGG: ctc:CTC02356 2.7e-129 aspartate kinase K00928; COG: COG0527 Aspartokinases; Psort location: Cytoplasmic, score: 8.87; Belongs to the aspartokinase family. (461 aa) |
| | hisE | phosphoribosyl-ATP diphosphatase; KEGG: sao:SAOUHSC_03008 4.1e-55 imidazole glycerol phosphate synthase subunit HisF, putative K01663; COG: COG0139 Phosphoribosyl-AMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.98; In the C-terminal section; belongs to the PRA-PH family. (428 aa) |
| | hisB | KEGG: cac:CAC0938 4.7e-54 hisB; imidazoleglycerol-phosphate dehydratase K01693; COG: COG0131 Imidazoleglycerol-phosphate dehydratase; Psort location: Cytoplasmic, score: 8.87. (195 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (443 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (211 aa) |
| | hisZ | ATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (415 aa) |
| | EDR47106.1 | Hypothetical protein; KEGG: ctc:CTC00993 0.0031 V-type sodium ATP synthase subunit G K02121; COG: NOG13209 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (212 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (665 aa) |
| | patB | Cystathionine beta-lyase PatB; KEGG: oih:OB2338 1.1e-70 aminotransferase K00842; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. (406 aa) |
| | asd | KEGG: lsl:LSL_0313 4.1e-142 asd; aspartate-semialdehyde dehydrogenase K00133; COG: COG0136 Aspartate-semialdehyde dehydrogenase; Psort location: Cytoplasmic, score: 8.87. (361 aa) |
| | argH | Argininosuccinate lyase; KEGG: dsy:DSY0786 3.8e-139 hypothetical protein K01755; COG: COG0165 Argininosuccinate lyase; Psort location: Cytoplasmic, score: 8.87. (459 aa) |
| | EDR47215.1 | KEGG: ctc:CTC02637 4.5e-33 phosphoglycerate mutase K01834; COG: COG0406 Fructose-2,6-bisphosphatase; Psort location: Cytoplasmic, score: 8.87. (213 aa) |
| | luxS | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (159 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (322 aa) |
| | aroD | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (253 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (273 aa) |
| | EDR46623.1 | Aminotransferase, class I/II; KEGG: ctc:CTC00825 5.6e-67 putative aspartate aminotransferase K00842; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; Psort location: Cytoplasmic, score: 8.87. (395 aa) |
| | thrH | KEGG: hch:HCH_02661 1.1e-54 thrH; phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein K01079; COG: COG0560 Phosphoserine phosphatase; Psort location: Cytoplasmic, score: 8.87. (209 aa) |
| | pfp | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (407 aa) |
| | glyA-2 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | sdaAB-2 | L-serine dehydratase, iron-sulfur-dependent, beta subunit; KEGG: tte:TTE1008 2.0e-53 sdaA; L-serine deaminase K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87; Belongs to the iron-sulfur dependent L-serine dehydratase family. (224 aa) |
| | sdaAA-2 | KEGG: chy:CHY_2457 3.0e-59 sdhA2; L-serine dehydratase, iron-sulfur-dependent, alpha subunit K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87. (289 aa) |
| | EDR45575.1 | ACT domain protein; KEGG: sat:SYN_01196 9.6e-24 acetolactate synthase small subunit K01651; Psort location: Cytoplasmic, score: 8.87. (156 aa) |
| | EDR45629.1 | Methionine synthase, vitamin-B12 independent; KEGG: lsl:LSL_0129 3.3e-69 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score: 8.87. (381 aa) |
| | EDR45646.1 | Amidohydrolase; KEGG: hso:HS_1434 7.1e-67 amaA; possible N-acyl-L-amino acid amidohydrolase K01436; COG: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; Psort location: Cytoplasmic, score: 8.87. (391 aa) |
| | EDR45691.1 | KEGG: gka:GK2197 6.4e-66 tyrA; prephenate dehydrogenase K04517; COG: COG0287 Prephenate dehydrogenase; Psort location: Cytoplasmic, score: 8.87. (364 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (432 aa) |
| | thrC | Threonine synthase; KEGG: cac:CAC0999 6.3e-162 thrC; threonine synthase K01733; COG: COG0498 Threonine synthase; Psort location: Cytoplasmic, score: 8.87. (509 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa) |
| | cysK | Cysteine synthase A; KEGG: chy:CHY_0808 1.1e-109 cysK; cysteine synthase A K01738; COG: COG0031 Cysteine synthase; Psort location: Cytoplasmic, score: 8.87; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa) |
| | rpe | KEGG: cpe:CPE1736 1.1e-59 ribulose-phosphate 3-epimerase K01783; COG: COG0036 Pentose-5-phosphate-3-epimerase; Psort location: Cytoplasmic, score: 8.87. (220 aa) |
| | EDR45847.1 | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (341 aa) |
| | hisC | KEGG: lla:L0065 6.3e-91 hisC; histidinol-phosphate aminotransferase K00817; COG: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Psort location: Cytoplasmic, score: 8.87; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (358 aa) |
| | EDR45850.1 | Aminotransferase, class I/II; KEGG: cac:CAC2832 5.0e-114 PLP-dependent aminotransferase K00811; COG: COG0436 Aspartate/tyrosine/aromatic aminotransferase; Psort location: Cytoplasmic, score: 8.87. (395 aa) |
| | EDR45852.1 | Amidohydrolase; KEGG: bca:BCE_3698 2.1e-83 hipO; peptidase, M20/M25/M40 family K01436; COG: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; Psort location: Cytoplasmic, score: 8.87. (379 aa) |
| | EDR45853.1 | Aminotransferase, class I/II; KEGG: cac:CAC2970 8.8e-101 patB; PLP-dependent aminotransferase, K00842; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; Psort location: Cytoplasmic, score: 8.87. (395 aa) |
| | EDR45877.1 | Hypothetical protein; COG: NOG21949 non supervised orthologous group. (305 aa) |
| | argD | Aminotransferase, acetylornithine/succinylornithine family; KEGG: cje:Cj0227 1.5e-112 argD; acetylornithine aminotransferase K00818; COG: COG4992 Ornithine/acetylornithine aminotransferase; Psort location: Cytoplasmic, score: 8.87; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (397 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (307 aa) |
| | argJ | Glutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa) |
| | EDR45885.1 | Acetyltransferase, GNAT family; KEGG: rba:RB7615 9.0e-12 putative acetyltransferase K00680; COG: COG0456 Acetyltransferases; Psort location: Cytoplasmic, score: 8.87. (143 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (415 aa) |
| | dapF-2 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (285 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (217 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (432 aa) |
| | EDR45971.1 | Hypothetical protein; COG: NOG04719 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (370 aa) |
| | EDR46160.1 | GIY-YIG catalytic domain protein; KEGG: mca:MCA0838 3.0e-06 type I restriction-modification system, R subunit K01153; COG: COG2827 Predicted endonuclease containing a URI domain. (86 aa) |
| | mtnN | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa) |
| | EDR46214.1 | Aconitase domain protein; KEGG: ecp:ECP_0784 6.2e-242 aconitate hydratase K01680; COG: COG1048 Aconitase A; Psort location: Cytoplasmic, score: 9.98. (759 aa) |
| | EDR46233.1 | KEGG: saa:SAUSA300_2505 6.3e-20 acetyltransferase, GNAT family K00680; COG: NOG18266 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (179 aa) |
| | prs-2 | KEGG: cpr:CPR_1519 1.9e-98 prs; ribose-phosphate pyrophosphokinase K00948; COG: COG0462 Phosphoribosylpyrophosphate synthetase; Psort location: Cytoplasmic, score: 8.87. (395 aa) |
| | pfkA-2 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (364 aa) |
| | fsa | Fructose-6-phosphate aldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | EDR46321.1 | Transketolase, thiamine diphosphate binding domain protein; KEGG: mmp:MMP1115 2.1e-76 transketolase, N terminal half K00615; COG: COG3959 Transketolase, N-terminal subunit. (266 aa) |
| | EDR46322.1 | Transketolase, pyridine binding domain protein; KEGG: chy:CHY_0166 2.3e-84 putative transketolase, C-terminal subunit K00615; COG: COG3958 Transketolase, C-terminal subunit; Psort location: Cytoplasmic, score: 8.87. (308 aa) |
| | EDR46332.1 | GIY-YIG catalytic domain protein; KEGG: mca:MCA0838 1.7e-05 type I restriction-modification system, R subunit K01153; COG: COG2827 Predicted endonuclease containing a URI domain; Psort location: Cytoplasmic, score: 8.87. (101 aa) |
| | EDR46362.1 | Methionine synthase, vitamin-B12 independent; KEGG: lsl:LSL_0129 6.8e-94 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score: 8.87. (371 aa) |
| | EDR46372.1 | Methionine synthase, vitamin-B12 independent; KEGG: lsl:LSL_0129 2.7e-90 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score: 8.87. (372 aa) |
| | EDR46396.1 | Hypothetical protein; COG: NOG32695 non supervised orthologous group. (154 aa) |
| | EDR46411.1 | KEGG: cno:NT01CX_0234 3.0e-132 citrate synthase I K01647; COG: COG0372 Citrate synthase; Psort location: Cytoplasmic, score: 9.98. (484 aa) |
| | EDR46416.1 | Amidohydrolase; KEGG: hso:HS_1434 2.5e-64 amaA; possible N-acyl-L-amino acid amidohydrolase K01436; COG: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; Psort location: Cytoplasmic, score: 8.87. (390 aa) |
| | EDR46507.1 | Class II glutamine amidotransferase; KEGG: gka:GK1431 0. glutamate synthaselarge subunit K00265; COG: COG0069 Glutamate synthase domain 2; Psort location: Cytoplasmic, score: 8.87. (1512 aa) |
| | EDR46508.1 | Pyridine nucleotide-disulfide oxidoreductase; KEGG: syn:sll1027 1.5e-144 gltD; NADH-dependent glutamate synthase small subunit K00269; COG: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; Psort location: Cytoplasmic, score: 9.98. (516 aa) |
| | pyc | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1175 aa) |
| | EDR45401.1 | Plasmid recombination enzyme; COG: NOG17369 non supervised orthologous group. (321 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (276 aa) |
| | EDR45512.1 | DNA-binding helix-turn-helix protein; KEGG: mmo:MMOB3450 0.00014 dam; adenine-specific DNA methyltransferase K06223; COG: NOG17530 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (100 aa) |
| | EDR45515.1 | DNA-binding helix-turn-helix protein; KEGG: mmo:MMOB3450 0.0028 dam; adenine-specific DNA methyltransferase K06223; Psort location: Cytoplasmic, score: 8.87. (100 aa) |
