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EDS08638.1 EDS08638.1 maf maf Cmk_5 Cmk_5 rluD_3 rluD_3 lspA lspA EDS08193.1 EDS08193.1 sepF sepF EDS08195.1 EDS08195.1 EDS08197.1 EDS08197.1 EDS08198.1 EDS08198.1 DacB_3 DacB_3 mgsA mgsA mrdB mrdB minE minE minD minD minC minC MrdA MrdA mreD mreD mreC mreC mreB_1 mreB_1 EDS08209.1 EDS08209.1 EDS08210.1 EDS08210.1 EDS08211.1 EDS08211.1 baiN baiN megL megL EDS08214.1 EDS08214.1 miaA miaA mutL mutL mutS mutS EDS08218.1 EDS08218.1 lytG lytG EDS08221.1 EDS08221.1 ltrA_3 ltrA_3 murA murA mepM_1 mepM_1 ftsW_2 ftsW_2 mraZ mraZ mraW mraW FtsL_2 FtsL_2 spoVD_2 spoVD_2 spoVD_1 spoVD_1 mraY mraY murD murD ftsW_1 ftsW_1 ftsZ ftsZ mgsA-2 mgsA-2 EDS07412.1 EDS07412.1 murC murC Cca Cca cwlC_1 cwlC_1 murB murB EDS06283.1 EDS06283.1 cwlD cwlD murG murG murE murE LytF LytF ripA ripA MepS MepS ywiB ywiB murI murI EDS05749.1 EDS05749.1 ddl ddl murF murF mrcA mrcA lspA_1 lspA_1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
EDS08638.1Hypothetical protein. (211 aa)
mafSeptum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (196 aa)
Cmk_5Hypothetical protein; KEGG: sat:SYN_01231 2.0e-30 cytidylate kinase K00945; COG: NOG14451 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (221 aa)
rluD_3Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (304 aa)
lspASignal peptidase II; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (169 aa)
EDS08193.1S4 domain protein; KEGG: ama:AM825 0.0049 sfhB; sfhb-like protein K06180; COG: COG2302 Uncharacterized conserved protein, contains S4-like domain; Psort location: Cytoplasmic, score: 8.87. (251 aa)
sepFHypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (184 aa)
EDS08195.1Pyridoxal phosphate enzyme, YggS family; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (231 aa)
EDS08197.1Hypothetical protein; COG: COG2155 Uncharacterized conserved protein. (73 aa)
EDS08198.1Radical SAM protein, TIGR01212 family; KEGG: btk:BT9727_4481 4.7e-38 conserved hypothetical protein, possible Fe-S oxidoreductase; COG: COG1242 Predicted Fe-S oxidoreductase; Psort location: Cytoplasmic, score: 8.87. (336 aa)
DacB_3Serine-type D-Ala-D-Ala carboxypeptidase; KEGG: chy:CHY_2101 6.2e-36 D-alanyl-D-alanine carboxypeptidase K07258; COG: COG1686 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (342 aa)
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (131 aa)
mrdBCell cycle protein, FtsW/RodA/SpoVE family; COG: COG0772 Bacterial cell division membrane protein; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the SEDS family. (374 aa)
minEPutative cell division topological specificity factor MinE; Psort location: Cytoplasmic, score: 8.87. (70 aa)
minDSeptum site-determining protein MinD; KEGG: eci:UTI89_C1360 7.8e-61 minD; cell division inhibitor, membrane ATPase MinD K03609; COG: COG2894 Septum formation inhibitor-activating ATPase; Psort location: Cytoplasmic, score: 8.87. (263 aa)
minCPutative septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization. (196 aa)
MrdAPenicillin-binding protein, transpeptidase domain protein; KEGG: ppd:Ppro_2545 4.2e-57 peptidoglycan glycosyltransferase K05364; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: CytoplasmicMembrane, score: 9.49. (984 aa)
mreDRod shape-determining protein MreD; COG: NOG16883 non supervised orthologous group; Psort location: CytoplasmicMembrane, score: 9.99. (172 aa)
mreCRod shape-determining protein MreC; Involved in formation and maintenance of cell shape. (292 aa)
mreB_1Cell shape determining protein, MreB/Mrl family; KEGG: hpa:HPAG1_1318 3.3e-37 rod shape-determining protein K01529; COG: COG1077 Actin-like ATPase involved in cell morphogenesis; Psort location: Cytoplasmic, score: 9.98. (340 aa)
EDS08209.1COG: COG2003 DNA repair proteins; Psort location: Cytoplasmic, score: 8.87; Belongs to the UPF0758 family. (230 aa)
EDS08210.1Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.75. (86 aa)
EDS08211.1Hypothetical protein; KEGG: gox:GOX1630 3.6e-63 putative oxidoreductase K00100; COG: COG2509 Uncharacterized FAD-dependent dehydrogenases; Psort location: Cytoplasmic, score: 8.87. (552 aa)
baiNFlavoprotein family protein; Involved in the secondary bile acid metabolism. Catalyzes two subsequent reductions of the double bonds within the bile acid A/B rings of 3-oxochol-4,6-dien-24-oyl-CoA and 12alpha-hydroxy-3-oxochol- 4,6-dien-24-oyl-CoA to yield 3-oxocholan-24-oyl-CoA and 12alpha- hydroxy-3-oxocholan-24-oyl-CoA, respectively. (409 aa)
megLAluminum resistance protein; KEGG: ava:Ava_4213 1.1e-100 Cys/Met metabolism pyridoxal-phosphate-dependent enzyme K01758; COG: COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance; Psort location: Cytoplasmic, score: 8.87. (428 aa)
EDS08214.1Hypothetical protein; Psort location: Cytoplasmic, score: 8.87. (83 aa)
miaAtRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (323 aa)
mutLDNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (652 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (876 aa)
EDS08218.1COG: COG4905 Predicted membrane protein; Psort location: CytoplasmicMembrane, score: 9.26. (138 aa)
lytGMannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; KEGG: cno:NT01CX_2157 9.9e-26 N-acetylmuramoyl-L-alanine amidase CwlL precursor (cellwall hydrolase) (autolysin) K01446; COG: COG1705 Muramidase (flagellum-specific); Psort location: Extracellular, score: 9.55. (500 aa)
EDS08221.1Toxin secretion/phage lysis holin; Psort location: CytoplasmicMembrane, score: 7.80. (172 aa)
ltrA_3Reverse transcriptase (RNA-dependent DNA polymerase); KEGG: rba:RB818 3.0e-25 reverse transcriptase/maturase K00986; COG: COG3344 Retron-type reverse transcriptase; Psort location: Cytoplasmic, score: 8.87. (309 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (430 aa)
mepM_1KEGG: cya:CYA_1627 1.7e-20 peptidase, M23B family; COG: COG0739 Membrane proteins related to metalloendopeptidases. (497 aa)
ftsW_2COG: COG0772 Bacterial cell division membrane protein; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the SEDS family. (385 aa)
mraZProtein MraZ; COG: COG2001 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87; Belongs to the MraZ family. (146 aa)
mraWS-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (311 aa)
FtsL_2Hypothetical protein. (197 aa)
spoVD_2Penicillin-binding protein, transpeptidase domain protein; KEGG: cac:CAC0329 1.6e-76 spoVD; sporulation specific penicillin-binding protein K03587; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: CytoplasmicMembrane, score: 9.49. (615 aa)
spoVD_1Penicillin-binding protein, transpeptidase domain protein; KEGG: tte:TTE1916 3.0e-91 ftsI4; Cell division protein FtsI/penicillin-binding protein 2 K03587; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: CytoplasmicMembrane, score: 9.70. (574 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (318 aa)
murDUDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (450 aa)
ftsW_1COG: COG0772 Bacterial cell division membrane protein; Psort location: CytoplasmicMembrane, score: 10.00; Belongs to the SEDS family. (362 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (413 aa)
mgsA-2Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (158 aa)
EDS07412.1Hypothetical protein. (121 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (487 aa)
CcaHDIG domain protein; KEGG: ctc:CTC01205 7.4e-104 tRNA nucleotidyltransferase (CCA-adding enzyme) K00974; COG: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; Psort location: Cytoplasmic, score: 8.87. (447 aa)
cwlC_1KEGG: bsu:BG10825 1.1e-31 cwlC; N-acetylmuramoyl-L-alanine amidase, peptidoglycan hydrolase, LytC amidase family K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: Cytoplasmic, score: 8.87. (253 aa)
murBUDP-N-acetylmuramate dehydrogenase; Cell wall formation. (310 aa)
EDS06283.1NlpC/P60 family protein; KEGG: baa:BA_0322 2.0e-14 NLP/P60 family K01446; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: Extracellular, score: 9.95. (300 aa)
cwlDKEGG: bce:BC0167 2.4e-34 spore-specific N-acetylmuramoyl-L-alanine amidase K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase. (226 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (355 aa)
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (504 aa)
LytFNlpC/P60 family protein; KEGG: psp:PSPPH_0470 1.7e-17 NLP/P60 family protein K01183; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: Extracellular, score: 9.95. (360 aa)
ripANlpC/P60 family protein; KEGG: bce:BC5234 1.5e-12 N-acetylmuramoyl-L-alanine amidase K01446; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: Extracellular, score: 9.95. (355 aa)
MepSNlpC/P60 family protein; KEGG: psp:PSPPH_0470 5.8e-10 NLP/P60 family protein K01183; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: Extracellular, score: 9.73. (403 aa)
ywiBCOG: COG4506 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87. (148 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (281 aa)
EDS05749.1Hypothetical protein; Psort location: Extracellular, score: 8.82. (42 aa)
ddlD-ala D-ala ligase N-terminal domain protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (356 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (457 aa)
mrcAPenicillin-binding protein, 1A family; KEGG: tte:TTE0314 1.1e-102 mrcA; Membrane carboxypeptidase (penicillin-binding protein) K05366; COG: COG0744 Membrane carboxypeptidase (penicillin-binding protein); Psort location: Extracellular, score: 9.55. (862 aa)
lspA_1Hypothetical protein; This protein specifically catalyzes the removal of signal peptides from prolipoproteins. (174 aa)
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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