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ecfA2_2 ecfA2_2 ecfA1_3 ecfA1_3 ykoC ykoC folT folT ecfT_1 ecfT_1 ecfA2_1 ecfA2_1 ecfA1_1 ecfA1_1 queT queT RibU_1 RibU_1 btuR btuR bioY2 bioY2 coaBC coaBC panT panT EDS04979.1 EDS04979.1 EDS04980.1 EDS04980.1 cbiD cbiD cobI cobI cobM cobM cbiG cbiG cobJ cobJ cobK cobK cobB cobB cobT cobT cobU_2 cobU_2 cobS cobS cobU_1 cobU_1 pspB pspB cobD cobD cobQ cobQ cobH cobH cbiM cbiM cbiN cbiN cbiQ cbiQ cbiO cbiO cbiK cbiK SirC SirC hemC hemC hemB hemB
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ecfA2_2KEGG: ser:SERP2358 1.3e-26 amino acid ABC transporter, ATP-binding protein K02000; COG: COG1122 ABC-type cobalt transport system, ATPase component; Psort location: CytoplasmicMembrane, score: 9.49. (268 aa)
ecfA1_3ABC transporter, ATP-binding protein; KEGG: nma:NMA0842 2.0e-32 fbpC; iron transport system ATP-binding protein K02010; COG: COG1122 ABC-type cobalt transport system, ATPase component; Psort location: CytoplasmicMembrane, score: 9.49. (289 aa)
ykoCCOG: COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; Psort location: CytoplasmicMembrane, score: 9.99. (251 aa)
folTHypothetical protein; COG: NOG18662 non supervised orthologous group; Psort location: CytoplasmicMembrane, score: 9.99. (173 aa)
ecfT_1Cobalt transport protein; Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (274 aa)
ecfA2_1ABC transporter, ATP-binding protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (284 aa)
ecfA1_1ABC transporter, ATP-binding protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (287 aa)
queTCOG: COG4708 Predicted membrane protein; Psort location: CytoplasmicMembrane, score: 9.99. (164 aa)
RibU_1Hypothetical protein; KEGG: oih:OB1717 0.0055 biotin synthase K01012; COG: COG3601 Predicted membrane protein; Psort location: CytoplasmicMembrane, score: 9.99. (256 aa)
btuRPutative cob(I)yrinic acid a,c-diamide adenosyltransferase; KEGG: tte:TTE0370 2.2e-26 btuR; ATP:corrinoid adenosyltransferase K00798; COG: COG2109 ATP:corrinoid adenosyltransferase; Psort location: Cytoplasmic, score: 9.98. (174 aa)
bioY2BioY family protein; KEGG: oih:OB1717 2.7e-26 biotin synthase K01012; COG: COG1268 Uncharacterized conserved protein; Psort location: CytoplasmicMembrane, score: 9.99. (189 aa)
coaBCPhosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (399 aa)
panTCOG: COG4684 Predicted membrane protein; Psort location: CytoplasmicMembrane, score: 9.99. (218 aa)
EDS04979.1Hypothetical protein. (82 aa)
EDS04980.1Hypothetical protein. (72 aa)
cbiDCobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (384 aa)
cobIKEGG: mst:Msp_0038 1.4e-31 cbiL; CbiL K03394; COG: COG2243 Precorrin-2 methylase; Psort location: Cytoplasmic, score: 8.87; Belongs to the precorrin methyltransferase family. (231 aa)
cobMKEGG: mta:Moth_1092 1.4e-68 precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase. (264 aa)
cbiGCbiG; KEGG: dde:Dde_3181 1.8e-33 precorrin-3B C17-methyltransferase K02189:K03395:K00594; COG: COG2073 Cobalamin biosynthesis protein CbiG; Psort location: Cytoplasmic, score: 8.87. (348 aa)
cobJKEGG: lmo:lmo1199 7.6e-63 cbiH; precorrin-3B C17-methyltransferase K03395; COG: COG1010 Precorrin-3B methylase; Psort location: Cytoplasmic, score: 8.87. (245 aa)
cobKprecorrin-6A reductase; KEGG: ctc:CTC00734 5.1e-57 cbiT; precorrin-6B methylase/decarboxylase cbiT/cbiE K03399:K02191; COG: COG2241 Precorrin-6B methylase 1; Psort location: Cytoplasmic, score: 8.87. (664 aa)
cobBKEGG: tte:TTE0375 2.4e-75 cobB; Cobyrinic acid a,c-diamide synthase K03401; COG: COG1797 Cobyrinic acid a,c-diamide synthase; Psort location: Cytoplasmic, score: 8.87. (470 aa)
cobTNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (353 aa)
cobU_2Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; KEGG: cps:CPS_3657 1.9e-18 cobP; bifunctional cobalamin biosynthesis protein CobP K02231; COG: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; Psort location: Cytoplasmic, score: 8.87. (179 aa)
cobSCobalamin-5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (260 aa)
cobU_1Hypothetical protein; KEGG: eco:b1993 2.6e-14 cobU; bifunctional: cobinamide kinase; cobinamide phosphate guanylyltransferase K02231; COG: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; Psort location: Cytoplasmic, score: 8.87. (125 aa)
pspBPhosphoglycerate mutase family protein; KEGG: cpe:CPE1038 2.5e-25 cobC; probable alpha-ribazole-5'-phosphate phosphatase K02226; COG: COG0406 Fructose-2,6-bisphosphatase; Psort location: Cytoplasmic, score: 8.87. (225 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (296 aa)
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (502 aa)
cobHKEGG: gsu:GSU2999 1.1e-45 cobH; precorrin-8X methylmutase K01833; COG: COG2082 Precorrin isomerase; Psort location: Cytoplasmic, score: 8.87. (224 aa)
cbiMCobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (256 aa)
cbiNCobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (108 aa)
cbiQCOG: COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; Psort location: CytoplasmicMembrane, score: 9.99. (300 aa)
cbiOCobalt ABC transporter, ATP-binding protein; Part of an ABC transporter complex. Responsible for energy coupling to the transport system. (273 aa)
cbiKCobalt chelatase (CbiK); KEGG: lin:lin1165 4.1e-55 cbiK; similar to anaerobic Cobalt Chelatase In Cobalamin Biosynthesis K02190; COG: COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase; Psort location: Cytoplasmic, score: 8.87. (261 aa)
SirCSiroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase. (163 aa)
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (803 aa)
hemBPorphobilinogen synthase; KEGG: aae:aq_2109 1.1e-102 hemB; delta-aminolevulinic acid dehydratase K01698; COG: COG0113 Delta-aminolevulinic acid dehydratase; Psort location: Cytoplasmic, score: 8.87; Belongs to the ALAD family. (325 aa)
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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