STRINGSTRING
cobU_2 cobU_2 purC purC YeiR YeiR cobQ_2 cobQ_2 yjiA yjiA btuR btuR ureG ureG cbiD cbiD cobI cobI cobM cobM cbiG cbiG cobJ cobJ cobK cobK cobB cobB cobT cobT cobS cobS cobU_1 cobU_1 cobD cobD cobQ cobQ cobH cobH cbiM cbiM cbiN cbiN SirC SirC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cobU_2Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; KEGG: cps:CPS_3657 1.9e-18 cobP; bifunctional cobalamin biosynthesis protein CobP K02231; COG: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; Psort location: Cytoplasmic, score: 8.87. (179 aa)
purCKEGG: cac:CAC1391 2.2e-81 purC; phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase K01923; COG: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Psort location: Cytoplasmic, score: 8.87; Belongs to the SAICAR synthetase family. (239 aa)
YeiRCobW/P47K family protein; KEGG: reh:H16_A0195 1.4e-31 putative GTPase (G3E family); COG: COG0523 Putative GTPases (G3E family); Psort location: Cytoplasmic, score: 8.87. (337 aa)
cobQ_2CobB/CobQ-like protein; KEGG: lsl:LSL_0587 1.6e-39 cobyric acid synthase K01957; COG: COG3442 Predicted glutamine amidotransferase; Psort location: Cytoplasmic, score: 8.87. (244 aa)
yjiACobW/P47K family protein; KEGG: reh:H16_A3373 7.8e-18 putative GTPase (G3E family); COG: COG0523 Putative GTPases (G3E family); Psort location: Cytoplasmic, score: 8.87. (309 aa)
btuRPutative cob(I)yrinic acid a,c-diamide adenosyltransferase; KEGG: tte:TTE0370 2.2e-26 btuR; ATP:corrinoid adenosyltransferase K00798; COG: COG2109 ATP:corrinoid adenosyltransferase; Psort location: Cytoplasmic, score: 9.98. (174 aa)
ureGCobW/P47K family protein; KEGG: reh:H16_A3373 3.9e-07 putative GTPase (G3E family); COG: COG0523 Putative GTPases (G3E family); Psort location: Cytoplasmic, score: 8.87. (365 aa)
cbiDCobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (384 aa)
cobIKEGG: mst:Msp_0038 1.4e-31 cbiL; CbiL K03394; COG: COG2243 Precorrin-2 methylase; Psort location: Cytoplasmic, score: 8.87; Belongs to the precorrin methyltransferase family. (231 aa)
cobMKEGG: mta:Moth_1092 1.4e-68 precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase. (264 aa)
cbiGCbiG; KEGG: dde:Dde_3181 1.8e-33 precorrin-3B C17-methyltransferase K02189:K03395:K00594; COG: COG2073 Cobalamin biosynthesis protein CbiG; Psort location: Cytoplasmic, score: 8.87. (348 aa)
cobJKEGG: lmo:lmo1199 7.6e-63 cbiH; precorrin-3B C17-methyltransferase K03395; COG: COG1010 Precorrin-3B methylase; Psort location: Cytoplasmic, score: 8.87. (245 aa)
cobKprecorrin-6A reductase; KEGG: ctc:CTC00734 5.1e-57 cbiT; precorrin-6B methylase/decarboxylase cbiT/cbiE K03399:K02191; COG: COG2241 Precorrin-6B methylase 1; Psort location: Cytoplasmic, score: 8.87. (664 aa)
cobBKEGG: tte:TTE0375 2.4e-75 cobB; Cobyrinic acid a,c-diamide synthase K03401; COG: COG1797 Cobyrinic acid a,c-diamide synthase; Psort location: Cytoplasmic, score: 8.87. (470 aa)
cobTNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (353 aa)
cobSCobalamin-5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (260 aa)
cobU_1Hypothetical protein; KEGG: eco:b1993 2.6e-14 cobU; bifunctional: cobinamide kinase; cobinamide phosphate guanylyltransferase K02231; COG: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; Psort location: Cytoplasmic, score: 8.87. (125 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (296 aa)
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (502 aa)
cobHKEGG: gsu:GSU2999 1.1e-45 cobH; precorrin-8X methylmutase K01833; COG: COG2082 Precorrin isomerase; Psort location: Cytoplasmic, score: 8.87. (224 aa)
cbiMCobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (256 aa)
cbiNCobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (108 aa)
SirCSiroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase. (163 aa)
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.