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EEU98345.1 EEU98345.1 EEU98346.1 EEU98346.1 aroA aroA aroF aroF aroQ aroQ aroK aroK aroC aroC aroB aroB EEU98353.1 EEU98353.1 EEU98354.1 EEU98354.1 ilvE ilvE ilvD ilvD ilvC ilvC ilvN ilvN ilvB ilvB ilvA ilvA EEU97744.1 EEU97744.1 EEU97757.1 EEU97757.1 aroD aroD leuB leuB leuD leuD leuC leuC leuA leuA aroF-2 aroF-2 dapL dapL dapF dapF asnB asnB EEU96229.1 EEU96229.1 thrB thrB EEU96231.1 EEU96231.1 EEU96263.1 EEU96263.1 EEU96049.1 EEU96049.1 dapB dapB dapA dapA asd asd EEU96011.1 EEU96011.1 thrC thrC EEU95816.1 EEU95816.1 asnA asnA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EEU98345.1Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (320 aa)
EEU98346.1KEGG: cno:NT01CX_0626 2.0e-48 prephenate dehydrogenase K00210; Psort location: Cytoplasmic, score: 8.96. (286 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (424 aa)
aroF3-deoxy-7-phosphoheptulonate synthase; KEGG: cpe:CPE0694 6.0e-102 phospho-2-dehydro-3-deoxyheptonate aldolase K03856; Psort location: Cytoplasmic, score: 8.96. (338 aa)
aroQDehydroquinase class II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (154 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (420 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (380 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (347 aa)
EEU98353.1Chorismate mutase; KEGG: bxe:Bxe_A0977 1.7e-42 bifunctional, chorismate mutase/prephenate dehydratase K01850; Psort location: Cytoplasmic, score: 9.97. (357 aa)
EEU98354.1Hypothetical protein. (42 aa)
ilvEBranched-chain-amino-acid transaminase; KEGG: bha:BH2156 8.6e-110 bcaT; branched-chain amino acid aminotransferase K00826; Psort location: Cytoplasmic, score: 8.96. (359 aa)
ilvDKEGG: tte:TTE0020 7.2e-193 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; Belongs to the IlvD/Edd family. (552 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
ilvNKEGG: sth:STH2689 1.5e-32 acetolactate synthase small subunit K01653; Psort location: Cytoplasmic, score: 8.96. (187 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 3.2e-142 ilvB; acetolactate synthase large subunit K01652. (554 aa)
ilvAKEGG: chy:CHY_2459 2.3e-102 ilvA2; threonine dehydratase K01754; Psort location: Cytoplasmic, score: 8.96. (401 aa)
EEU97744.1Beta-eliminating lyase; KEGG: sag:SAG1756 6.6e-112 putative threonine aldolase K01620; Psort location: Cytoplasmic, score: 8.96. (340 aa)
EEU97757.1Aminotransferase, class I/II; KEGG: blo:BL0783 2.4e-137 probable aminotransferase K00811; Psort location: Cytoplasmic, score: 8.96. (394 aa)
aroD3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (252 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (357 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa)
leuAPutative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (550 aa)
aroF-23-deoxy-7-phosphoheptulonate synthase; KEGG: cac:CAC0892 3.6e-104 phospho-2-dehydro-3-deoxyheptonate aldolase K03856; Psort location: Cytoplasmic, score: 8.96. (347 aa)
dapLLL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (417 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (279 aa)
asnBAsparagine synthase (glutamine-hydrolyzing); KEGG: lla:L00396 1.1e-159 asnB; asparagine synthetase B K01953; Psort location: Cytoplasmic, score: 8.96. (524 aa)
EEU96229.1KEGG: chy:CHY_1909 1.4e-109 aspartate kinase, monofunctional class K00928; Psort location: Cytoplasmic, score: 8.96; Belongs to the aspartokinase family. (399 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (301 aa)
EEU96231.1KEGG: mta:Moth_1307 5.1e-73 homoserine dehydrogenase K00003; Psort location: Cytoplasmic, score: 8.96. (411 aa)
EEU96263.1KEGG: spr:spr1792 9.4e-136 lysA; diaminopimelate decarboxylase K01586; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (464 aa)
EEU96049.1ACT domain protein; KEGG: ace:Acel_2012 3.0e-14 aspartate kinase K00928. (155 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (252 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa)
asdKEGG: cac:CAC0568 2.0e-126 asd; aspartate semialdehyde dehydrogenase (gene asd) K00133; Belongs to the aspartate-semialdehyde dehydrogenase family. (378 aa)
EEU96011.1Hypothetical protein. (44 aa)
thrCThreonine synthase; KEGG: smu:SMU.70 8.9e-108 thrC; putative threonine synthase K01733. (440 aa)
EEU95816.1L-asparaginase, type I; KEGG: ctc:CTC01877 1.0e-67 L-asparaginase K01424; Psort location: Periplasmic, score: 9.44. (335 aa)
asnAKEGG: ljo:LJ0511 6.0e-102 aspartate-ammonia ligase K01914; Psort location: Cytoplasmic, score: 10.00. (337 aa)
Your Current Organism:
Faecalibacterium prausnitzii A2165
NCBI taxonomy Id: 411483
Other names: F. prausnitzii A2-165, Faecalibacterium prausnitzii A2-165
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