(8 nodes) Valine, leucine and isoleucine biosynthesis network (Faecalibacterium prausnitzii A2165)

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Your Input:
	ilvD	KEGG: tte:TTE0020 7.2e-193 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; Belongs to the IlvD/Edd family. (552 aa)
	ilvC	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
	ilvN	KEGG: sth:STH2689 1.5e-32 acetolactate synthase small subunit K01653; Psort location: Cytoplasmic, score: 8.96. (187 aa)
	ilvB	Acetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 3.2e-142 ilvB; acetolactate synthase large subunit K01652. (554 aa)
	leuB	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (357 aa)
	leuD	3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa)
	leuC	3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa)
	leuA	Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (550 aa)

Your Current Organism:

Faecalibacterium prausnitzii A2165

NCBI taxonomy Id: 411483
Other names: F. prausnitzii A2-165, Faecalibacterium prausnitzii A2-165

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ilvB	ilvC	FAEPRAA2165_00374	FAEPRAA2165_00372	Acetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 3.2e-142 ilvB; acetolactate synthase large subunit K01652.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.999
ilvB	ilvD	FAEPRAA2165_00374	FAEPRAA2165_00371	Acetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 3.2e-142 ilvB; acetolactate synthase large subunit K01652.	KEGG: tte:TTE0020 7.2e-193 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; Belongs to the IlvD/Edd family.	0.994
ilvB	ilvN	FAEPRAA2165_00374	FAEPRAA2165_00373	Acetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 3.2e-142 ilvB; acetolactate synthase large subunit K01652.	KEGG: sth:STH2689 1.5e-32 acetolactate synthase small subunit K01653; Psort location: Cytoplasmic, score: 8.96.	0.999
ilvB	leuA	FAEPRAA2165_00374	FAEPRAA2165_01131	Acetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 3.2e-142 ilvB; acetolactate synthase large subunit K01652.	Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.	0.949
ilvB	leuB	FAEPRAA2165_00374	FAEPRAA2165_01127	Acetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 3.2e-142 ilvB; acetolactate synthase large subunit K01652.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.987
ilvB	leuC	FAEPRAA2165_00374	FAEPRAA2165_01130	Acetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 3.2e-142 ilvB; acetolactate synthase large subunit K01652.	3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.860
ilvB	leuD	FAEPRAA2165_00374	FAEPRAA2165_01128	Acetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 3.2e-142 ilvB; acetolactate synthase large subunit K01652.	3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.	0.915
ilvC	ilvB	FAEPRAA2165_00372	FAEPRAA2165_00374	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	Acetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 3.2e-142 ilvB; acetolactate synthase large subunit K01652.	0.999
ilvC	ilvD	FAEPRAA2165_00372	FAEPRAA2165_00371	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	KEGG: tte:TTE0020 7.2e-193 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; Belongs to the IlvD/Edd family.	0.999
ilvC	ilvN	FAEPRAA2165_00372	FAEPRAA2165_00373	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	KEGG: sth:STH2689 1.5e-32 acetolactate synthase small subunit K01653; Psort location: Cytoplasmic, score: 8.96.	0.999
ilvC	leuA	FAEPRAA2165_00372	FAEPRAA2165_01131	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.	0.970
ilvC	leuB	FAEPRAA2165_00372	FAEPRAA2165_01127	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.976
ilvC	leuC	FAEPRAA2165_00372	FAEPRAA2165_01130	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.982
ilvC	leuD	FAEPRAA2165_00372	FAEPRAA2165_01128	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.	0.968
ilvD	ilvB	FAEPRAA2165_00371	FAEPRAA2165_00374	KEGG: tte:TTE0020 7.2e-193 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; Belongs to the IlvD/Edd family.	Acetolactate synthase, large subunit, biosynthetic type; KEGG: cac:CAC3169 3.2e-142 ilvB; acetolactate synthase large subunit K01652.	0.994
ilvD	ilvC	FAEPRAA2165_00371	FAEPRAA2165_00372	KEGG: tte:TTE0020 7.2e-193 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; Belongs to the IlvD/Edd family.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.999
ilvD	ilvN	FAEPRAA2165_00371	FAEPRAA2165_00373	KEGG: tte:TTE0020 7.2e-193 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; Belongs to the IlvD/Edd family.	KEGG: sth:STH2689 1.5e-32 acetolactate synthase small subunit K01653; Psort location: Cytoplasmic, score: 8.96.	0.971
ilvD	leuA	FAEPRAA2165_00371	FAEPRAA2165_01131	KEGG: tte:TTE0020 7.2e-193 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; Belongs to the IlvD/Edd family.	Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.	0.992
ilvD	leuB	FAEPRAA2165_00371	FAEPRAA2165_01127	KEGG: tte:TTE0020 7.2e-193 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; Belongs to the IlvD/Edd family.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.972
ilvD	leuC	FAEPRAA2165_00371	FAEPRAA2165_01130	KEGG: tte:TTE0020 7.2e-193 ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; Belongs to the IlvD/Edd family.	3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.963