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fba fba CBO0210 CBO0210 gap1 gap1 pgK pgK tpiA tpiA gpmI gpmI eno eno CBO0246 CBO0246 adhE adhE fbp fbp gcvT gcvT gcvH gcvH gcvP gcvP gcvP-2 gcvP-2 pdhD1 pdhD1 lplA1 lplA1 CBO0759 CBO0759 glcA glcA CBO1006 CBO1006 etfB etfB etfB-2 etfB-2 glcD glcD gapA2 gapA2 aldH aldH fchA fchA folD folD nifJ1 nifJ1 CBO1197 CBO1197 gapN gapN tal tal bdh bdh CBO1438 CBO1438 CBO1503 CBO1503 ldh ldh deoC deoC rbsK rbsK metF metF CBO1622 CBO1622 metH metH CBO1627 CBO1627 acoR acoR CBO1629 CBO1629 acoA acoA acoB acoB acoX acoX acoC acoC acoL acoL lplA2 lplA2 opuCA opuCA opuCB opuCB CBO1643 CBO1643 gluD gluD gadA gadA eutE eutE CBO2119 CBO2119 CBO2126 CBO2126 CBO2153 CBO2153 fldZ fldZ etfA1 etfA1 etfB1 etfB1 acdB acdB ackA ackA ptA ptA rpe rpe glyA glyA glpX glpX nifJ2 nifJ2 glsA glsA ctfA ctfA ctfB ctfB ppdK ppdK ptb1 ptb1 CBO3197 CBO3197 CBO3198 CBO3198 bcd bcd thl thl hbd hbd crt crt act act pflA pflA pgi pgi ldhA1 ldhA1 etfA2 etfA2 etfB2 etfB2 acdA acdA rex rex ccmA-5 ccmA-5 pyc pyc pykF pykF pfkA pfkA tkt tkt tkt-2 tkt-2 CBO3421 CBO3421 CBO3422 CBO3422 CBO3423 CBO3423 CBO3424 CBO3424 CBO3425 CBO3425 buk1 buk1 ptb2 ptb2 buk2 buk2 fhs fhs murI murI glnA glnA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
gene fusions
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Your Input:
fbaSimilar to Entamoeba histolytica putative fructose-1,6-bisphosphate aldolase Ald SWALL:Q8MTW2 (EMBL:AY057996) (326 aa) fasta scores: E(): 5.8e-51, 49.2 id in 315 aa, and to Clostridium tetani fructose-bisphosphate aldolase ctc00341 SWALL:Q898U8 (EMBL:AE015937) (320 aa) fasta scores: E(): 3.3e-80,76.75 38d in 314 aa. (308 aa)
CBO0210NAD-dependent malic enzyme; Similar to Bacillus stearothermophilus NAD-dependent malic enzyme SWALL:MAOX_BACST (SWALL:P16468) (478 aa) fasta scores: E(): 7e-79, 59.38 38d in 389 aa,and to Clostridium tetani NAD-dependent malic enzyme ctc00356 SWALL:Q898T6 (EMBL:AE015937) (389 aa) fasta scores: E(): 6.1e-102, 73.52 38d in 389 aa; Also similar to CBO0246 (66.6 38d). (390 aa)
gap1Similar to Bacillus megaterium glyceraldehyde 3-phosphate dehydrogenase Gap SWALL:G3P_BACME (SWALL:P23722) (334 aa) fasta scores: E(): 4.3e-78, 64.86 id in 333 aa, and to Bacillus stearothermophilus glyceraldehyde 3-phosphate dehydrogenase Gap SWALL:G3P_BACST (SWALL:P00362) (334 aa) fasta scores: E(): 4.1e-82, 69.06 38d in 333 aa; Also similar to CBO1095 (66.26 38d). (335 aa)
pgKPhosphoglycerate kinase; Similar to Bacillus megaterium phosphoglycerate kinase Pgk SWALL:PGK_BACME (SWALL:P24269) (394 aa) fasta scores: E(): 2.4e-80, 57.07 38d in 396 aa, and to Clostridium acetobutylicum phosphoglycerate kinase Pgk or cac0710 SWALL:PGK_CLOAB (SWALL:O52632) (397 aa) fasta scores: E(): 5.4e-110, 77.44 38d in 399 aa. (398 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
CBO0246Similar to Corynebacterium melassecola malic enzyme MalE SWALL:Q9KIF8 (EMBL:AF234535) (392 aa) fasta scores: E(): 3.3e-63, 52.91 38d in 378 aa, and to Escherichia coli NADP-dependent malic enzyme MaeB or b2463 SWALL:MAO2_ECOLI (SWALL:P76558) (759 aa) fasta scores: E(): 2.7e-57, 48.88 id in 403 aa; Also similar to CBO0210 (66.6 38d). (390 aa)
adhESimilar to Clostridium acetobutylicum aldehyde-alcohol dehydrogenase [includes: alcohol dehydrogenase; acetaldehyde dehydrogenase [acetylating] (EC 1.2.1.10) (acdh); pyruvate-formate-lyase deactivase (pfl deactivase)] AdhE or Aad or cap0162 SWALL:ADHE_CLOAB (SWALL:P33744) (862 aa) fasta scores: E(): 2.6e-212,65.04 38d in 861 aa, and to Escherichia coli, and Escherichia coli O157:H7 aldehyde-alcohol dehydrogenase [includes: alcohol dehydrogenase; acetaldehyde dehydrogenase [acetylating] (EC 1.2.1.10) (acdh); pyruvate-formate-lyase deactivase (pfl deactivase)] AdhE or Ana or b1241 or z20 [...] (862 aa)
fbpFructose-1,6-bisphosphatase. (668 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (375 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa)
gcvPGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (446 aa)
gcvP-2Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (484 aa)
pdhD1Dihydrolipoyl dehydrogenase (E3 component of pyruvate complex). (462 aa)
lplA1Lipoate-protein ligase A. (325 aa)
CBO0759Conserved hypothetical protein (pseudogene); Pseudogene. This CDS contains an in-frame TGA stop codon. Similar to Halobacterium sp. orf h1434 vng5177C SWALL:O52025 (EMBL:AF016485) (391 aa) fasta scores: E(): 3.1e-38, 44.44 38d in 279 aa. (182 aa)
glcALactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family. (507 aa)
CBO1006Conserved hypothetical protein. (424 aa)
etfBElectron transfer flavoprotein beta-subunit. (262 aa)
etfB-2Electron transfer flavoprotein alpha-subunit. (400 aa)
glcDGlycolate oxidase subunit. (465 aa)
gapA2Glyceraldehyde 3-phosphate dehydrogenase A; Also similar to CBO0226 (66.26 38d); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
aldHAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (456 aa)
fchAMethenyltetrahydrofolate cyclohydrolase. (210 aa)
folDPutative methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)
nifJ1Putative pyruvate-flavodoxin oxidoreductase; Also similar to CBO2760 (65.74 38d). (1172 aa)
CBO1197Putative flavin containing amine oxidoreductase. (577 aa)
gapNNADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (486 aa)
talPutative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
bdhNADH-dependent butanol dehydrogenase. (387 aa)
CBO1438Alcohol dehydrogenase. (399 aa)
CBO1503Putative NADH/NADPH oxidoreductase. (339 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (318 aa)
deoCPutative deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (212 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (303 aa)
metF5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (295 aa)
CBO1622Conserved hypothetical protein. (229 aa)
metHPutative methionine synthase. (792 aa)
CBO1627Hypothetical protein; No significant database matches. (35 aa)
acoRSignal-transduction and transcriptional-control protein. (650 aa)
CBO1629Conserved hypothetical protein. (123 aa)
acoAAcetoin:2,6-dichlorophenolindophenol oxidoreductase alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (327 aa)
acoBAcetoin:2,6-dichlorophenolindophenol oxidoreductase beta subunit. (323 aa)
acoXAcetoin catabolism protein X; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (331 aa)
acoCDihydrolipoamide acetyltransferase component of acetoin dehydrogenase complex. (436 aa)
acoLDihydrolipoamide dehydrogenase component of acetoin dehydrogenase complex. (463 aa)
lplA2Lipoate-protein ligase. (331 aa)
opuCAGlycine betaine/carnitine/choline transport ATP-binding protein. (386 aa)
opuCBGlycine betaine/carnitine/choline transport system permease protein opucb. (528 aa)
CBO1643Alcohol dehydrogenase. (388 aa)
gluDNAD-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (421 aa)
gadAGlutamate decarboxylase alpha; Belongs to the group II decarboxylase family. (467 aa)
eutEPutative aldehyde-alcohol dehydrogenase. (532 aa)
CBO2119Putative aldehyde-alcohol dehydrogenase. (497 aa)
CBO2126Putative propanediol utilization: propanol dehydrogenase. (380 aa)
CBO2153Putative transaldolase. (238 aa)
fldZCinnamate reductase; This enzyme was purified from C. sporogenes and its N-terminus sequenced (Dickert et al. 2000 Eur. J. Biochem. 267, 3874-3884. (665 aa)
etfA1Electron transfer flavoprotein alpha-subunit. (349 aa)
etfB1Electron transfer flavoprotein beta-subunit. (261 aa)
acdBacyl-CoA dehydrogenase, short-chain specific. (377 aa)
ackAConserved hypothetical protein (pseudogene); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
ptAPhosphate acetyltransferase. (332 aa)
rpePutative ribulose-phosphate 3-epimerase; Similar to the C-terminal region of Solanum tuberosum ribulose-phosphate 3-epimerase, chloroplast precursor SWALL:RPE_SOLTU (SWALL:Q43843) (280 aa) fasta scores: E(): 1.7e-34, 51.4 38d in 214 aa. (216 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
glpXPutative fructose-1,6-bisphosphatase class II GlpX. (324 aa)
nifJ2Pyruvate-flavodoxin oxidoreductase; Also similar to CBO1192 (65.74 38d). (1192 aa)
glsAGlutaminase; Belongs to the glutaminase family. (305 aa)
ctfAButyrate-acetoacetate CoA-transferase subunit A. (238 aa)
ctfBButyrate-acetoacetate CoA-transferase subunit B. (217 aa)
ppdKPyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (877 aa)
ptb1Phosphate butyryltransferase; Also similar to CBO3427 (53.37 38d). (300 aa)
CBO3197Electron transfer flavoprotein alpha-subunit. (334 aa)
CBO3198Electron transfer flavoprotein beta-subunit. (259 aa)
bcdbutyryl-CoA dehydrogenase. (379 aa)
thlacetyl-CoA acetyltransferase (thiolase); Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
hbd3-hydroxybutyryl-CoA dehydrogenase. (276 aa)
crt3-hydroxybutyryl-CoA dehydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa)
actFormate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (232 aa)
pflAFormate acetyltransferase. (742 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (450 aa)
ldhA1Putative acetyltransferase (pseudogene); Pfam match to entry PF00583 Acetyltransf,Acetyltransferase (GNAT) family, score 28.4, E-value 4.9e-09; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa)
etfA2Electron transfer flavoprotein alpha-subunit; N-terminal extension relative to homologues. (398 aa)
etfB2Electron transfer flavoprotein beta-subunit. (264 aa)
acdAPutative acyl-CoA dehydrogenase. (377 aa)
rexConserved hypothetical protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (210 aa)
ccmA-5Putative ABC transporter ATP-binding protein. (640 aa)
pycPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1144 aa)
pykFPyruvate kinase; Belongs to the pyruvate kinase family. (585 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
tktTransketolase, pyridine binding subunit; Similar to C-terminal region of several transketolases including Homo sapiens transketolase Tkt or Tkt1 SWALL:TKT_HUMAN (SWALL:P29401) (623 aa) fasta scores: E(): 6e-37, 40.69 38d in 317 aa. (313 aa)
tkt-2Transketolase, thiamine disphosphate-bindin subunit; Similar to the N-terminal region of several transketolase including Homo sapiens transketolase Tkt or Tkt1 SWALL:TKT_HUMAN (SWALL:P29401) (623 aa) fasta scores: E(): 3.8e-36, 42.85 38d in 273 aa. (274 aa)
CBO3421Putative subunit of pyruvate:flavodoxin oxidoreductase. (176 aa)
CBO3422Putative subunit of pyruvate:flavodoxin oxidoreductase. (249 aa)
CBO3423Putative subunit of pyruvate:flavodoxin oxidoreductase. (356 aa)
CBO3424Putative ferredoxin subunit of pyruvate:flavodoxin oxidoreductase. (69 aa)
CBO3425Conserved hypothetical protein. (230 aa)
buk1Butyrate kinase 1; Also similar to CBO3428 (57.670 38d. in 352 aa overlap); Belongs to the acetokinase family. (356 aa)
ptb2Phosphate butyryltransferase; Also similar to CBO3118 (53.37 38d). (303 aa)
buk2Butyrate kinase 2; Also similar to CBO3426 (57.670 38d. in 352 aa overlap); Belongs to the acetokinase family. (364 aa)
fhsFormate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (557 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (257 aa)
glnAGlutamine synthetase. (632 aa)
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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