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CBO0037 CBO0037 cobB-2 cobB-2 tmk tmk tdK tdK upp upp CBO0146 CBO0146 CBO0196 CBO0196 cinA cinA rnr rnr surE surE adeC adeC pbuX pbuX xpt xpt panD panD panC panC panB panB CBO0474 CBO0474 nadE nadE CBO0629 CBO0629 CBO0768 CBO0768 add add birA birA pncA pncA xpt-2 xpt-2 panE panE dut dut guaD guaD CBO1410 CBO1410 nadC nadC nadB nadB nadA nadA pyrR pyrR pyrP pyrP pyrK1 pyrK1 gltD gltD cmk cmk pdp pdp punA punA nudF nudF nadK nadK CBO2003 CBO2003 CBO2005 CBO2005 CBO2006 CBO2006 CBO2026 CBO2026 CBO2188 CBO2188 CBO2189 CBO2189 CBO2190 CBO2190 CBO2191 CBO2191 CBO2274 CBO2274 CBO2302 CBO2302 purB purB coaD coaD coaBC coaBC gmk gmk udk udk purL purL CBO2621 CBO2621 CBO2723 CBO2723 CBO2819 CBO2819 CBO2820 CBO2820 pyrR-2 pyrR-2 ribH ribH ribA ribA ribE ribE ribD ribD purD purD purH purH purN purN purM purM purF purF purC purC purE purE hydA hydA pbuX-2 pbuX-2 CBO2901 CBO2901 purF-2 purF-2 cdd cdd apt apt hpt hpt CBO3181 CBO3181 pyrE pyrE pyrD pyrD pyrK pyrK pyrF pyrF pyrC pyrC pyrI pyrI pyrB pyrB rdgB rdgB guaB guaB gltA gltA pyrK2 pyrK2 thyX thyX coaX coaX prsA prsA purA purA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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CBO0037Putative NUDIX-family hydrolase; Similar to Clostridium tetani predicted NADH pyrophosphatase ctc00069 SWALL:Q899U7 (EMBL:AE015936) (175 aa) fasta scores: E(): 5.5e-45, 70 38d in 160 aa, and to Clostridium acetobutylicum N-terminal Zn-ribbon domain and C-terminal MutT domain, yjad ortholog cac0145 SWALL:Q97MP7 (EMBL:AE007526) (174 aa) fasta scores: E(): 4.7e-34,54.37 38d in 160 aa. (162 aa)
cobB-2Putative regulatory protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (247 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (231 aa)
tdKThymidine kinase; Similar to Rhodothermus sp. thymidine kinase Tdk SWALL:KITH_RHOSI (SWALL:Q9ZIG2) (213 aa) fasta scores: E(): 2.6e-34, 53.26 38d in 184 aa, and to Clostridium acetobutylicum thymidine kinase cac2887 SWALL:Q97F65 (EMBL:AE007786) (195 aa) fasta scores: E(): 5.1e-56,77.48 38d in 191 aa. (191 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
CBO0146Putative zinc-binding protein; Similar to Clostridium tetani comE operon protein 2 ctc00309 SWALL:Q898X8 (EMBL:AE015936) (162 aa) fasta scores: E(): 6.7e-56, 81.48 38d in 162 aa, and to Clostridium acetobutylicum deoxycytidylate deaminase cac2876 SWALL:Q97F76 (EMBL:AE007785) (162 aa) fasta scores: E(): 1.9e-44, 67.28 38d in 162 aa. (162 aa)
CBO0196Putative kinase; Similar to Clostridium tetani uridine kinase ctc00344 SWALL:Q898U6 (EMBL:AE015937) (552 aa) fasta scores: E(): 6.7e-122, 61.05 38d in 552 aa, and to Clostridium acetobutylicum fision threonyl-trna synthetase cac0672 SWALL:Q97L90 (EMBL:AE007582) (553 aa) fasta scores: E(): 4.3e-123, 61.84 38d in 553 aa. (552 aa)
cinAPutative molybdopterin binding; Similar to Bacillus subtilis cina-like protein CinA or bsu16930 SWALL:CINA_BACSU (SWALL:P46323) (416 aa) fasta scores: E(): 6.2e-57, 44.92 38d in 394 aa, and to Clostridium acetobutylicum competence-damage inducible protein, cina cac3586 SWALL:Q97D94 (EMBL:AE007855) (411 aa) fasta scores: E(): 1.3e-92, 60.29 38d in 408 aa; Belongs to the CinA family. (409 aa)
rnrRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (725 aa)
surEAcid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (252 aa)
adeCAdenine deaminase; Similar to Bacillus subtilis adenine deaminase AdeC or Ade or bsu14520 SWALL:ADEC_BACSU (SWALL:P39761) (577 aa) fasta scores: E(): 5e-63, 36.17 38d in 575 aa; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (599 aa)
pbuXXanthine permease; Similar to Bacillus subtilis xanthine permease PbuX or bsu22060 SWALL:PBUX_BACSU (SWALL:P42086) (438 aa) fasta scores: E(): 1e-52, 37.77 38d in 405 aa. (433 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (275 aa)
CBO0474Similar to Bacillus subtilis ADP-ribose pyrophosphatase nudf or bsu23610 SWALL:ADPP_BACSU (SWALL:P54570) (185 aa) fasta scores: E(): 0.00014, 27.54 id in 167 aa, and to Homo sapiens ADP-sugar pyrophosphatase ysa1h nudt5 SWALL:NUD5_HUMAN (SWALL:Q9UKK9) (219 aa) fasta scores: E(): 2.2e-13, 35.91 id in 181 aa. (182 aa)
nadEGlutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (638 aa)
CBO0629N-carbamoyl-L-amino acid hydrolase. (407 aa)
CBO0768Putative phage-related deoxyuridylate hydroxymethyltransferase. (324 aa)
addAdenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (335 aa)
birABirA bifunctional protein [includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (327 aa)
pncAPyrazinamidase/nicotinamidase. (186 aa)
xpt-2Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
panEPutative 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (303 aa)
dutPutative deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (208 aa)
guaDGuanine deaminase. (157 aa)
CBO1410Putative nicotinate phosphribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (493 aa)
nadCNicotinate-nucleotide pyrophosphorylase [carboxylating]; Belongs to the NadC/ModD family. (278 aa)
nadBL-aspartate oxidase. (433 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa)
pyrRPutative pyrimidine operon regulatory protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (178 aa)
pyrPPutative uracil permease. (447 aa)
pyrK1Putative dihydroorotate dehydrogenase electron transfer subunit; Also similar to CBO3305 (67.698 38d. in 291 aa overlap). (295 aa)
gltDGlutamate synthase [NADPH] small chain. (460 aa)
cmkCytidylate kinase. (217 aa)
pdpPyrimidine-nucleoside phosphorylase. (434 aa)
punAPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (271 aa)
nudFADP-ribose pyrophosphatase. (178 aa)
nadKProbable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (281 aa)
CBO2003Conserved hypothetical protein. (92 aa)
CBO2005Putative phosphoribosyltransferase. (181 aa)
CBO2006Putative membrane protein. (354 aa)
CBO2026Putative hydrolase. (238 aa)
CBO2188Amidohydrolase family protein. (450 aa)
CBO2189Putative uric acid permease. (447 aa)
CBO2190Putative membrane protein; No significant database matches. (299 aa)
CBO2191Putative amino acid permease. (439 aa)
CBO2274Putative ferredoxin; Similar to Clostridium acetobutylicum predicted flavodoxin oxidoreductase CAC1860 SWALL:Q97HZ6 (EMBL:AE007694) (328 aa) fasta scores: E(): 8.3e-70,54.87 38d in 328 aa. C-terminal region is weakly similar to Bacillus subtilis dihydroorotate dehydrogenase electron transfer subunit PyrK or PyrZ or BSU15530 SWALL:PYRK_BACSU (SWALL:P25983) (256 aa) fasta scores: E(): 1.4e-06, 24.47 id in 237 aa. (327 aa)
CBO2302Similar to Clostridium perfringens hypothetical protein CPE1416 SWALL:Q8XKH9 (EMBL:AP003190) (193 aa) fasta scores: E(): 6.6e-11, 28.49 38d in 179 aa, and to Thermoanaerobacter tengcongensis acetyltransferases,including N-acetylases of ribosomal proteins RIMl2 or TTE1542 SWALL:Q8R9Q7 (EMBL:AE013110) (187 aa) fasta scores: E(): 2.4e-10, 27.16 38d in 173 aa. CDS contains a frameshift after codon 132. (450 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa)
coaDPutative phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa)
coaBCPutative coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (395 aa)
gmkPutative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (209 aa)
udkUridine kinase. (206 aa)
purLFormylglycinamidine ribonucleotide synthetase. (1221 aa)
CBO2621Putative inosine-uridine preferring nucleoside hydrolase. (287 aa)
CBO2723Conserved hypothetical protein. (342 aa)
CBO2819Putative iron-sulfur oxidoreductase. (411 aa)
CBO2820Putative Pyridine nucleotide-disulphide oxidoreductase. (438 aa)
pyrR-2Pyrimidine operon regulatory protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (182 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa)
ribA3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (401 aa)
ribERiboflavin synthase alpha chain. (216 aa)
ribDDiaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (365 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (413 aa)
purHBifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase. (499 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (205 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (334 aa)
purFAmidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (482 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (234 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa)
hydAD-hydantoinase. (464 aa)
pbuX-2Xanthine permease. (468 aa)
CBO2901Putative purine transporter. (480 aa)
purF-2Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (460 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (132 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
hptHypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa)
CBO3181Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (92 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (191 aa)
pyrDDihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (298 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (251 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (283 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (396 aa)
pyrIAspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (146 aa)
pyrBAspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (307 aa)
rdgBConserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (199 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa)
gltAPutative pyridine nucleotide-disulphide oxidoreductase. (461 aa)
pyrK2Putative dihydroorotate dehydrogenase electron transfer subunit; Self match: 67.698 38dentity (67.9310ngapped) in 291 aa overlap with CBO1644. (296 aa)
thyXThymidylate synthase complementing protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (252 aa)
coaXConserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (258 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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