STRINGSTRING
mdeA mdeA metK metK cysK1 cysK1 cysE cysE Alr Alr CBO0291 CBO0291 CBO0344 CBO0344 CBO0417 CBO0417 CBO0418 CBO0418 CBO0419 CBO0419 ceo ceo cysK cysK luxS luxS metC metC CBO0727 CBO0727 dapB dapB dkgA dkgA CBO1014 CBO1014 CBO1079 CBO1079 CBO1126 CBO1126 serA serA CBO1128 CBO1128 asdA asdA cysK2 cysK2 sdhB sdhB sdhA sdhA mtnK mtnK mtnA mtnA CBO1270 CBO1270 pepD-2 pepD-2 CBO1400 CBO1400 aroB aroB mtnN mtnN aroF aroF aroA aroA asnA asnA hisZ hisZ hisG hisG hisD hisD hisB hisB hisH hisH hisA hisA hisC hisC hisF hisF hisI hisI hisE hisE thrC thrC thrB thrB lysC lysC hom hom alr alr aspC aspC aroH aroH CBO1810 CBO1810 CBO1812 CBO1812 rluB rluB metA metA hom-2 hom-2 cysD cysD aroQ aroQ aroK aroK dapF dapF CBO1963 CBO1963 CBO2015 CBO2015 CBO2020 CBO2020 catB catB aroB-2 aroB-2 pepD-3 pepD-3 CBO2233 CBO2233 CBO2328 CBO2328 aspC-2 aspC-2 CBO2410 CBO2410 CBO2516 CBO2516 aroE aroE CBO2706 CBO2706 CBO2741 CBO2741 CBO2753 CBO2753 CBO2756 CBO2756 CBO2757 CBO2757 CBO2758 CBO2758 CBO2759 CBO2759 pepD pepD CBO2907 CBO2907 CBO2908 CBO2908 CBO2909 CBO2909 CBO3010 CBO3010 aroC aroC asd asd dapA dapA dapB-2 dapB-2 CBO3154 CBO3154 dapD dapD CBO3165 CBO3165 fldH fldH CBO3335 CBO3335 lysA lysA lysC-2 lysC-2 CBO3343 CBO3343 speD speD alr-2 alr-2 tdcB tdcB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mdeASimilar to Pseudomonas putida methionine gamma-lyase MdeA SWALL:MEGL_PSEPU (SWALL:P13254) (398 aa) fasta scores: E(): 3e-82, 53.03 38d in 396 aa, and to Clostridium tetani cys/met metabolism lyase ctc02530 SWALL:Q890V5 (EMBL:AE015944) (398 aa) fasta scores: E(): 3.2e-115, 73.61 38d in 398 aa. (400 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (391 aa)
cysK1Cysteine synthase 1; Also similar to CBO0205 (53.5 38d); Belongs to the cysteine synthase/cystathionine beta- synthase family. (304 aa)
cysESimilar to Bacillus subtilis serine acetyltransferase CysE or CusA or bsu00930 SWALL:CYSE_BACSU (SWALL:Q06750) (217 aa) fasta scores: E(): 4.3e-35, 61.07 38d in 167 aa, and to Clostridium tetani serine acetyltransferase ctc00351 SWALL:Q898U0 (EMBL:AE015937) (186 aa) fasta scores: E(): 2.6e-47,74.45 38d in 184 aa. (198 aa)
AlrAlanine racemase; Similar to Treponema pallidum alanine racemase Alr or tp0681 SWALL:ALR_TREPA (SWALL:Q56346) (377 aa) fasta scores: E(): 9.7e-37, 35.93 38d in 384 aa, and to Clostridium acetobutylicum alanine racemase 1 Alr1 or cac0492 SWALL:ALR1_CLOAB (SWALL:Q97LR2) (386 aa) fasta scores: E(): 8e-87, 58.98 38d in 395 aa. (404 aa)
CBO0291Probable dehydratase; Similar to Escherichia coli, and Escherichia coli O157:H7 phosphogluconate dehydratase edd or b1851 or z2903 or ecs2561 SWALL:EDD_ECOLI (SWALL:P25530) (603 aa) fasta scores: E(): 5.8e-37, 31.08 38d in 505 aa, and to Clostridium acetobutylicum dihydroxyacid dehydratase cac3604 SWALL:Q97D76 (EMBL:AE007856) (572 aa) fasta scores: E(): 1.4e-145, 63.79 38d in 569 aa; Belongs to the IlvD/Edd family. (571 aa)
CBO0344Similar to Clostridium perfringens probable proline dipeptidase cpe2497 SWALL:Q8XHI6 (EMBL:AP003194) (358 aa) fasta scores: E(): 1.7e-79, 56.11 38d in 360 aa. (360 aa)
CBO0417Putative 2-isopropylmalate synthase; Similar to Streptomyces hygroscopicus 2-phosphinomethylmalic acid synthase PmmS SWALL:Q9LCB4 (EMBL:AB029822) (440 aa) fasta scores: E(): 3.5e-55,38.53 38d in 436 aa, and to Salmonella typhimurium 2-isopropylmalate synthase LeuA or stm0113 SWALL:LEU1_SALTY (SWALL:P15875) (522 aa) fasta scores: E(): 7.1e-10, 25.91 38d in 355 aa. (452 aa)
CBO0418Putative aconitase; Similar to Clostridium acetobutylicum aconitase a cac0971 SWALL:Q97KE8 (EMBL:AE007613) (642 aa) fasta scores: E(): 4e-183, 76.01 38d in 642 aa. (641 aa)
CBO0419Similar to Coccidioides immitis isocitrate dehydrogenase IcdH SWALL:Q8X1D0 (EMBL:AF439265) (347 aa) fasta scores: E(): 2e-58, 51.35 38d in 333 aa. (333 aa)
ceoN(5)-(carboxyethyl)ornithine synthase. (317 aa)
cysKCysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (302 aa)
luxSS-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (150 aa)
metCCystathionine beta-lyase. (380 aa)
CBO0727Conserved hypothetical protein. (208 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (265 aa)
dkgA2,5-diketo-D-gluconic acid reductase. (281 aa)
CBO1014Putative aromatic amino acid aminotransferase. (394 aa)
CBO1079Putative phosphoserine phosphatase. (241 aa)
CBO1126Putative serine--glyoxylate aminotransferase. (357 aa)
serAPutative D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (314 aa)
CBO1128Conserved hypothetical protein. (440 aa)
asdAL-aspartate beta-decarboxylase. (547 aa)
cysK2Cysteine synthase 2; Also similar to CBO0205 (53.5 38d); Belongs to the cysteine synthase/cystathionine beta- synthase family. (309 aa)
sdhBPutative L-serine dehydratase, beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (224 aa)
sdhAPutative L-serine dehydratase, alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (296 aa)
mtnK5-methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (403 aa)
mtnAPutative methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (349 aa)
CBO1270Putative transporter (partial); Partial CDS. Similar to the N-terminal region of the mentioned database matches; was marked partial. (215 aa)
pepD-2Putative aminoacyl-histidine dipeptidase. (487 aa)
CBO1400Putative aminotransferase. (392 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa)
mtnN5'-methylthioadenosine/S-adenosylhomocysteine nuclosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa)
aroFPutative 2-dehydro-3-deoxyphosphooctonate aldolase. (266 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (442 aa)
asnAPutative aspartate--ammonia ligase. (340 aa)
hisZPutative ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (411 aa)
hisGPutative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (215 aa)
hisDPutative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
hisBImidazoleglycerol-phosphate dehydratase; Similar to the C-terminal region of the Escherichia coli entry which corresponds to the imidazoleglycerol-phosphate dehydratase domain. (196 aa)
hisHImidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (242 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (354 aa)
hisFImidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (110 aa)
hisEphosphoribosyl-ATP pyrophosphatase; Similar to the C-terminal region of histidine biosynthesis bifunctional protein HisIE which corresponds to the phosphoribosyl-ATP pyrophosphohydrolase domain. (110 aa)
thrCThreonine synthase. (493 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (297 aa)
lysCPutative aspartokinase; Belongs to the aspartokinase family. (439 aa)
homHomoserine dehydrogenase. (425 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (389 aa)
aspCAspartate aminotransferase. (396 aa)
aroHChorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (123 aa)
CBO1810Putative exported protein. (407 aa)
CBO1812RpiR-family transcriptional regulator. (294 aa)
rluBRibosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. (236 aa)
metAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (298 aa)
hom-2Homoserine dehydrogenase. (408 aa)
cysDO-acetylhomoserine sulfhydrylase. (426 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (147 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (170 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (273 aa)
CBO1963Putative aminotransferase. (389 aa)
CBO2015Aspartate aminotransferase. (383 aa)
CBO2020Putative aminotransferase. (379 aa)
catBChloramphenicol acetyltransferase. (221 aa)
aroB-23-dehydroquinate synthase. (379 aa)
pepD-3Putative aminoacyl-histidine dipeptidase. (482 aa)
CBO2233Putative threonine aldolase. (342 aa)
CBO2328Putative C-5 cytosine-specific DNA methylase. (340 aa)
aspC-2Aspartate aminotransferase. (397 aa)
CBO2410Putative aspartokinase; Belongs to the aspartokinase family. (401 aa)
CBO2516Putative L-asparaginase. (333 aa)
aroEPutative shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (258 aa)
CBO2706Putative asparagine synthetase. (665 aa)
CBO2741Putative FlgN protein protein. (134 aa)
CBO2753Conserved hypothetical protein. (677 aa)
CBO2756Putative aminotransferase; Possible alternative translational start site. (288 aa)
CBO2757Haloacid dehalogenase-like hydrolase. (213 aa)
CBO2758Conserved hypothetical protein. (133 aa)
CBO2759Hypothetical protein; No significant database matches. Doubtful CDS. (35 aa)
pepDAminoacyl-histidine dipeptidase. (478 aa)
CBO2907Putative peptidase. (543 aa)
CBO2908Putative signaling protein. (165 aa)
CBO2909Putative modulator of ions transport. (441 aa)
CBO3010Conserved hypothetical protein; Belongs to the UPF0735 family. (145 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (374 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (330 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
dapB-2Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (251 aa)
CBO3154Putative aminotransferase. (389 aa)
dapDPutative transferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (236 aa)
CBO3165Putative acetyltransferase. (168 aa)
fldHD-phenyllactate dehydrogenase; Downstream convergently transcribed paralogue; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (331 aa)
CBO3335Cyclic beta 1-2 glucan synthetase. (2882 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (428 aa)
lysC-2Aspartokinase; Belongs to the aspartokinase family. (400 aa)
CBO3343Putative Xaa-his dipeptidase. (463 aa)
speDS-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (116 aa)
alr-2Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (386 aa)
tdcBThreonine dehydratase catabolic. (407 aa)
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.