STRINGSTRING
CBO0183 CBO0183 CBO0187 CBO0187 queG queG rnfC rnfC rnfD rnfD rnfG rnfG rnfE rnfE rnfA rnfA rnfB rnfB CBO0375 CBO0375 CBO0376 CBO0376 CBO0377 CBO0377 CBO0388 CBO0388 tpx tpx CBO0521 CBO0521 CBO0612 CBO0612 CBO0613 CBO0613 CBO0614 CBO0614 CBO0823 CBO0823 CBO0824 CBO0824 CBO0825 CBO0825 pspE pspE CBO1136 CBO1136 CBO1241 CBO1241 grxC grxC trxB1 trxB1 grdX grdX grdE grdE grdB grdB trxB2 trxB2 trxA trxA grdA grdA grdC grdC grdD grdD CBO1273 CBO1273 CBO1391 CBO1391 CBO1413 CBO1413 CBO1489 CBO1489 CBO1491 CBO1491 cobW cobW CBO1493 CBO1493 mtbC mtbC mtbA mtbA CBO1575 CBO1575 CBO1576 CBO1576 CBO1577 CBO1577 CBO1578 CBO1578 CBO1579 CBO1579 CBO1580 CBO1580 CBO1581 CBO1581 CBO1647 CBO1647 ccdA2 ccdA2 CBO1820 CBO1820 CBO1827 CBO1827 msrA msrA CBO1930 CBO1930 CBO1931 CBO1931 CBO2028 CBO2028 CBO2029 CBO2029 pepQ pepQ pepIP pepIP CBO2099 CBO2099 CBO2243 CBO2243 msrB msrB CBO2277 CBO2277 CBO2460 CBO2460 prdB1 prdB1 CBO2463 CBO2463 prdA1 prdA1 CBO2465 CBO2465 prdC1 prdC1 CBO2467 CBO2467 CBO2473 CBO2473 prdF prdF prdE prdE prdD prdD prdB2 prdB2 CBO2479 CBO2479 prdA2 prdA2 CBO2481 CBO2481 prdC2 prdC2 prdC3 prdC3 prdC4 prdC4 CBO2574 CBO2574 CBO2575 CBO2575 CBO2765 CBO2765 CBO2807 CBO2807 selB selB selA selA selD selD CBO3180 CBO3180 proC proC CBO3183 CBO3183 CBO3184 CBO3184 CBO3185 CBO3185 CBO3246 CBO3246 CBO3247 CBO3247 CBO3250 CBO3250 CBO3251 CBO3251 CBO3252 CBO3252 CBO3253 CBO3253 CBO3254 CBO3254 CBO3255 CBO3255 CBO3256 CBO3256 CBO3257 CBO3257 trxB3 trxB3 trxC trxC CBO3577 CBO3577 CBO3586 CBO3586
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBO0183Putative pyridine nucleotide-disulphide oxidoreductase; Similar to Fusobacterium nucleatum coenzyme a disulfide reductase/ disulfide bond regulator domain fn1903 SWALL:Q8RHU1 (EMBL:AE010492) (810 aa) fasta scores: E(): 1e-163, 56.35 38d in 818 aa, and to Fusobacterium nucleatum subsp. vincentii ATCC 49256 coenzyme a disulfide reductase/ disulfide bond regulator domain fnv2089 SWALL:Q7P7P1 (EMBL:AABF01000012) (809 aa) fasta scores: E(): 2.7e-159, 55.5 38d in 818 aa; Belongs to the sulfur carrier protein TusA family. (817 aa)
CBO0187Putative exported protein; Similar to Nitrosomonas europaea putative transmembrane protein ne2212 SWALL:Q82SU2 (EMBL:BX321863) (140 aa) fasta scores: E(): 4.3e-05, 25.83 38d in 120 aa,and to Pseudomonas aeruginosa hypothetical protein Pa5130 pa5130 SWALL:Q9HU54 (EMBL:AE004926) (139 aa) fasta scores: E(): 7.6e-05, 29.16 38d in 120 aa. (134 aa)
queGSimilar to Clostridium tetani iron-sulfur cluster-binding protein ctc00352 SWALL:Q898T9 (EMBL:AE015937) (327 aa) fasta scores: E(): 2.3e-75,61.12 38d in 319 aa. (321 aa)
rnfCElectron transport complex protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (439 aa)
rnfDElectron transport complex protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family. (310 aa)
rnfGElectron transport complex protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family. (223 aa)
rnfEElectron transport complex protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. (199 aa)
rnfAElectron transport complex protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. (192 aa)
rnfBElectron transport complex protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (277 aa)
CBO0375Putative membrane protein; Similar to Clostridium tetani heptaprenyl diphosphate synthase component I ctc01025 SWALL:Q896H9 (EMBL:AE015939) (181 aa) fasta scores: E(): 2.6e-38,63.37 38d in 172 aa. (178 aa)
CBO0376Putative exported protein; Similar to Clostridium tetani membrane associated protein ctc01026 SWALL:Q896H8 (EMBL:AE015939) (132 aa) fasta scores: E(): 1.8e-16, 43.28 38d in 134 aa. (130 aa)
CBO0377Putative lipoprotein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. (344 aa)
CBO0388Conserved hypothetical protein; Similar to Methanopyrus kandleri had family hydrolase, a mk0529 SWALL:Q8TXY0 (EMBL:AE010347) (158 aa) fasta scores: E(): 4.9e-13, 35.03 38d in 157 aa. (156 aa)
tpxThiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (164 aa)
CBO0521Superoxide dismutase [fe]. (216 aa)
CBO0612Putative membrane protein. (379 aa)
CBO0613Two-component response regulator. (270 aa)
CBO0614Two-component sensor kinase. (432 aa)
CBO0823Putative membrane protein. (93 aa)
CBO0824Conserved hypothetical protein. (60 aa)
CBO0825Conserved hypothetical protein. (82 aa)
pspEPhage shock protein (rhodanese). (103 aa)
CBO1136Conserved hypothetical protein. (154 aa)
CBO1241Putative membrane protein. (349 aa)
grxCPutative glutaredoxin. (75 aa)
trxB1Thioredoxin reductase. (313 aa)
grdXPutative component of glycine reductase complex. (125 aa)
grdEPutative component of glycine reductase complex. (428 aa)
grdBPutative glycine reductase complex component b gamma subunit; Selenoprotein. This CDS contains an opal stop codon that is read-through as selenocysteine. (432 aa)
trxB2Thioredoxin reductase. (313 aa)
trxAThioredoxin; Belongs to the thioredoxin family. (106 aa)
grdAGlycine/sarcosine/betaine reductase complex component A; Selenoprotein. This CDS contains an opal stop codon that is read-through as selenocysteine. (157 aa)
grdCGlycine/sarcosine/betaine reductase complex component C beta subunit. (512 aa)
grdDPutative glycine/sarcosine/betaine reductase complex component C alpha subunit; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (388 aa)
CBO1273Putative membrane protein. (119 aa)
CBO1391Putative peptide methionine sulfoxide reductase. (212 aa)
CBO1413Conserved hypothetical protein. (182 aa)
CBO1489Putative methylcobamide:CoM methyltransferase; Also similar to CBO1498 (40.6 38d.); Belongs to the uroporphyrinogen decarboxylase family. (350 aa)
CBO1491Putative iron-sulfur cluster protein. (576 aa)
cobWPutative cobalamin biosynthesis protein. (309 aa)
CBO1493Putative methylcobamide:CoM methyltransferase; Belongs to the uroporphyrinogen decarboxylase family. (290 aa)
mtbCDimethylamine corrinoid protein. (220 aa)
mtbAPutative methylcobamide:CoM methyltransferase; Belongs to the uroporphyrinogen decarboxylase family. (340 aa)
CBO1575Putative membrane protein. (231 aa)
CBO1576Conserved hypothetical protein; Belongs to the sulfur carrier protein TusA family. (73 aa)
CBO1577Putative membrane protein. (175 aa)
CBO1578LysR-family transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (296 aa)
CBO1579Putative sodium/alanine symporter. (416 aa)
CBO1580Putative oxidoreductase. (566 aa)
CBO1581Putative membrane protein. (418 aa)
CBO1647Signal-transduction and transcriptional-control protein (pseudogene); Putative prophage remnant. (233 aa)
ccdA2Cytochrome C-type biogenesis protein. (228 aa)
CBO1820Thioredoxin. (143 aa)
CBO1827Putative lipoprotein. (164 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (157 aa)
CBO1930ABC transporter, ATP-binding/permease protein. (620 aa)
CBO1931ABC transporter, ATP-binding/permease protein. (775 aa)
CBO2028Putative proton-dependent oligopeptide transporter; This CDS is also similar to the adjacent CDS,CBO2029, (77.828 38dentity in 442 aa overlap). (449 aa)
CBO2029Putative proton-dependent oligopeptide transporter; This CDS is also similar to the adjacent CDS,CBO2028, (77.828 38dentity in 442 aa overlap). (448 aa)
pepQXaa-proline dipeptidase. (362 aa)
pepIPProline iminopeptidase; Releases the N-terminal proline from various substrates. Belongs to the peptidase S33 family. (293 aa)
CBO2099Putative proline iminopeptidase. (301 aa)
CBO2243Putative uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (356 aa)
msrBPutative methionine sulfoxide reductase; Similar to the C-terminal region of Streptococcus pneumoniae, and Streptococcus pneumoniae peptide methionine sulfoxide reductase MsrA/MsrB 2 MsrAB2 or msrA or sp0660 or spr0577 SWALL:MAB2_STRPN (SWALL:Q97RX3) (311 aa) fasta scores: E(): 6.1e-34, 63.12 38d in 141 aa, and to the full length Clostridium perfringens peptide methionine sulfoxide reductase CPE1607 SWALL:MSRB_CLOPE (SWALL:Q8XJZ6) (147 aa) fasta scores: E(): 2.4e-49, 84.13 id in 145 aa. (149 aa)
CBO2277Putative superoxide dismutase [Mn/Fe]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (198 aa)
CBO2460Putative membrane protein. (292 aa)
prdB1Similar to Clostridium sticklandii proline reductase PrdB SWALL:Q9Z4Q7 (EMBL:AJ130879) (242 aa) fasta scores: E(): 8.5e-70, 79.07 38d in 239 aa. CDS contains an in frame UGA codon for probable selenocysteine insertion. (238 aa)
CBO2463Conserved hypothetical protein. (91 aa)
prdA1Putative proline reductase protein; Highly similar to CBO2480 (84.5 38d), CBO2483 (63.9 38d). (704 aa)
CBO2465Hypothetical protein; No significant database matches. (56 aa)
prdC1Putative electron transferring subunit of proline reductase; Similar to the N-terminal region of Clostridium sticklandii electron transfer protein PrdC SWALL:Q9L4Q5 (EMBL:AJ130879) (402 aa) fasta scores: E(): 6e-59, 47.13 id in 367 aa. (372 aa)
CBO2467Putative membrane protein. (298 aa)
CBO2473Putative integral membrane protein. (289 aa)
prdFPutative proline racemase; Belongs to the proline racemase family. (335 aa)
prdEPutative component of proline reductase. (156 aa)
prdDPutative component of proline reductase. (258 aa)
prdB2Putative subunit of proline reductase; Similar to Clostridium sticklandii proline reductase PrdB SWALL:Q9Z4Q7 (EMBL:AJ130879) (242 aa) fasta scores: E(): 1.1e-71, 80.33 38d in 239 aa. CDS contains an in frame UGA codon for probable selenocysteine insertion. (240 aa)
CBO2479Conserved hypothetical protein. (91 aa)
prdA2Putative subunit of proline reductase. (702 aa)
CBO2481Hypothetical protein; No significant database matches. (58 aa)
prdC2Putative electron transferring subunit of proline reductase; Similar to the N-terminal region of Clostridium sticklandii electron transfer protein PrdC SWALL:Q9L4Q5 (EMBL:AJ130879) (402 aa) fasta scores: E(): 9.7e-61,48.77 38d in 367 aa. (372 aa)
prdC3Putative proline reductase (partial); Similar to the N-terminal region of Clostridium sticklandii proline reductase proprotein, two subunits PrdA SWALL:Q9Z4P6 (EMBL:AJ130879) (630 aa) fasta scores: E(): 9.2e-15, 33.94 38d in 218 aa. Possible gene remnant; was marked partial. (434 aa)
prdC4Putative proline reductase (partial); Similar to the N-terminal region of Clostridium sticklandii proline reductase proprotein, two subunits PrdA SWALL:Q9Z4P6 (EMBL:AJ130879) (630 aa) fasta scores: E(): 1.9e-20, 53.47 38d in 144 aa. Possible gene remnant; was marked partial. (436 aa)
CBO2574Conserved hypothetical protein; Belongs to the sulfur carrier protein TusA family. (194 aa)
CBO2575Ornithine cyclodeaminase/mu-crystallin family protein. (329 aa)
CBO2765Conserved hypothetical protein. (467 aa)
CBO2807Putative iron-sulfur-binding protein. (213 aa)
selBSelenocysteine-specific elongation factor. (635 aa)
selAL-seryl-tRNA(sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (462 aa)
selDSelenide,water dikinase 1; Synthesizes selenophosphate from selenide and ATP. (358 aa)
CBO3180Putative membrane protein. (291 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa)
CBO3183Putative pyruvate formate lyase. (787 aa)
CBO3184Putative pyruvate formate-lyase 2 activating enzyme. (252 aa)
CBO3185Putative transcriptional regulator. (189 aa)
CBO3246Conserved hypothetical protein. (110 aa)
CBO3247Putative ABC transporter ATP-binding protein. (252 aa)
CBO3250Putative ABC transporter, permease protein; 5 probable transmembrane helices predicted for CBO3249 by TMHMM2.0 at aa 28-46, 89-106, 119-138, 143-162 and 183-205. (178 aa)
CBO3251Putative secreted protein. (72 aa)
CBO3252Hypothetical protein. (46 aa)
CBO3253Hypothetical protein. (162 aa)
CBO3254Putative lipoprotein; Appears to have an extended C-terminus compared to most homologues. (366 aa)
CBO3255Putative lipoprotein. (154 aa)
CBO3256Putative permease. (363 aa)
CBO3257Hypothetical protein. (86 aa)
trxB3Thioredoxin reductase. (287 aa)
trxCThioredoxin; Belongs to the thioredoxin family. (105 aa)
CBO3577Putative nitroreductase. (179 aa)
CBO3586Putative glycosyl transferase. (414 aa)
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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