STRINGSTRING
hypB hypB CBO0432 CBO0432 hypA hypA CBO0434 CBO0434 thiE thiE thiM thiM thiD1 thiD1 CBO0518 CBO0518 CBO0538 CBO0538 CBO0539 CBO0539 CBO0540 CBO0540 CBO0541 CBO0541 CBO0545 CBO0545 mscL mscL CBO0556 CBO0556 CBO0657 CBO0657 norV norV ric ric CBO0660 CBO0660 CBO0767A CBO0767A CBO0769 CBO0769 thiD2 thiD2 CBO0772 CBO0772 sspH sspH CBO0790 CBO0790 sseA sseA cobC cobC cobS cobS CBO0822 CBO0822 CBO0907 CBO0907 cobU cobU cobQ cobQ cbiB cbiB cobD cobD cbiM cbiM cbiN cbiN cbiQ cbiQ CBO0919 CBO0919 hemC hemC hemD hemD CBO0922 CBO0922 hemB hemB cobB cobB cobH cobH CBO0928 CBO0928 CBO0929 CBO0929 CBO0930 CBO0930 CBO0931 CBO0931 CBO0932 CBO0932 CBO0933 CBO0933 CBO0934 CBO0934 CBO0935 CBO0935 cbiD cbiD cbiE cbiE CBO0938 CBO0938 cbiT cbiT CBO0940 CBO0940 CBO0941 CBO0941 CBO0941A CBO0941A CBO0942 CBO0942 CBO0943 CBO0943 CBO0945 CBO0945 cbiL cbiL cbiF cbiF cbiG cbiG cbiH cbiH cbiJ cbiJ CBO0951 CBO0951 cbiK cbiK pduX pduX cobA cobA CBO0955 CBO0955 nirC nirC asrA asrA asrB asrB asrC asrC CBO0993A CBO0993A CBO0996 CBO0996 CBO1032 CBO1032 norV-2 norV-2 rbr rbr cooS cooS CBO1332 CBO1332 CBO1333 CBO1333 CBO1340 CBO1340 CBO1341 CBO1341 CBO1546 CBO1546 CBO1658 CBO1658 CBO1659 CBO1659 CBO1674 CBO1674 asrC-2 asrC-2 ftnA ftnA CBO1828 CBO1828 CBO1828A CBO1828A CBO1829 CBO1829 CBO1830 CBO1830 CBO1831 CBO1831 CBO1832 CBO1832 hypE hypE hypD hypD hypF hypF hypQ4 hypQ4 CBO1837 CBO1837 hypQ3 hypQ3 hupD hupD hupL hupL hupS hupS CBO1969 CBO1969 CBO1970 CBO1970 ccmA-4 ccmA-4 CBO1972 CBO1972 codA codA codB codB CBO2074 CBO2074 CBO2075 CBO2075 CBO2076 CBO2076 CBO2207 CBO2207 pdxA pdxA CBO2209 CBO2209 CBO2210 CBO2210 cooS-2 cooS-2 hypA-2 hypA-2 hypB-2 hypB-2 thiM-2 thiM-2 CBO2254 CBO2254 bioD bioD bioB-2 bioB-2 CBO2260 CBO2260 CBO2260A CBO2260A CBO2261 CBO2261 CBO2262 CBO2262 CBO2263 CBO2263 CBO2264 CBO2264 fprA1 fprA1 CBO2842 CBO2842 CBO2843 CBO2843 CBO2854 CBO2854 CBO2855 CBO2855 CBO2904 CBO2904 thiC thiC rub rub rbr3A rbr3A CBO3219 CBO3219 perR perR CBO3302 CBO3302 CBO3326 CBO3326 CBO3333 CBO3333 CBO3334 CBO3334 CBO3341 CBO3341 ftsH-2 ftsH-2 ecfT ecfT ecfA ecfA ecfA-2 ecfA-2 CBO3550 CBO3550 CBO3551 CBO3551 CBO3552 CBO3552 CBO3578 CBO3578 CBO3579 CBO3579 CBO3580 CBO3580 CBO3581 CBO3581 bioB bioB thiH thiH hydF hydF CBO3614 CBO3614 CBO3615 CBO3615 CBO3617 CBO3617 CBO3618 CBO3618
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hypBHydrogenase nickel incorporation protein; Similar to Escherichia coli, and Escherichia coli O6 hydrogenase isoenzymes nickel incorporation protein HypB or b2727 or c3287 SWALL:HYPB_ECOLI (SWALL:P24190) (290 aa) fasta scores: E(): 3e-28, 40.74 38d in 216 aa. (223 aa)
CBO0432Putative pyridine nucleotide-disulphide oxidoreductase; Similar to Moorella thermoacetica formate dehydrogenase beta subunit fdhB SWALL:P77907 (EMBL:U73807) (707 aa) fasta scores: E(): 5.5e-36, 34.26 38d in 502 aa. (892 aa)
hypASimilar to Bradyrhizobium japonicum hydrogenase nickel incorporation protein HypA or bll6932 SWALL:HYPA_BRAJA (SWALL:Q45256) (113 aa) fasta scores: E(): 6.6e-08, 30 38d in 110 aa. (114 aa)
CBO0434Putative membrane protein; No significant database matches. (328 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (205 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (263 aa)
thiD1Phosphomethylpyrimidine kinase; This CDS is also similar to CBO0771 (52.308 identity in 260 aa overlap). (266 aa)
CBO0518Putative oxygen binding protein. (137 aa)
CBO0538Putative membrane protein. (146 aa)
CBO0539Putative membrane protein. (331 aa)
CBO0540Hypothetical protein; No significant database matches. (46 aa)
CBO0541Putative membrane-associated protease. (269 aa)
CBO0545Putative [2Fe-2S] binding protein. (70 aa)
mscLPutative antibiotic resistance ABC transporter (pseudogene); Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (133 aa)
CBO0556Putative membrane protein. (227 aa)
CBO0657Crp-family transcriptional regulator. (236 aa)
norVAnaerobic nitric oxide reductase flavorubredoxin. (410 aa)
ricConserved hypothetical protein; Di-iron-containing protein involved in the repair of iron- sulfur clusters; Belongs to the RIC family. (232 aa)
CBO0660Conserved hypothetical protein. (251 aa)
CBO0767AConserved hypothetical protein. (153 aa)
CBO0769Putative methyltransferase. (252 aa)
thiD2Phosphomethylpyrimidine kinase; This CDS is also similar to CBO0451 (52.308 identity in 260 aa overlap). (275 aa)
CBO0772Hypothetical protein; No significant database matches. (77 aa)
sspHPutative small, acid-soluble spore protein; Also similar to CBO1236 (31.7 38d.). (62 aa)
CBO0790Putative membrane protein. (259 aa)
sseAPutative 3-mercaptopyruvate sulfurtransferase. (279 aa)
cobCAlpha-ribazole-5'-phosphate phosphatase; Belongs to the phosphoglycerate mutase family. (204 aa)
cobSCobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (248 aa)
CBO0822Conserved hypothetical protein. (258 aa)
CBO0907Putative membrane protein. (182 aa)
cobUBifunctional cobalamin biosynthesis protein [includes: cobinamide kinase; cobinamide phosphate guanylyltransferase]. (185 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (493 aa)
cbiBCobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (320 aa)
cobDL-threonine-O-3-phosphate decarboxylase. (362 aa)
cbiMPutative cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (239 aa)
cbiNCobalt transport protein cbin; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (99 aa)
cbiQPutative cobalt transport protein. (227 aa)
CBO0919Putative precorrin oxidase. (220 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (290 aa)
hemDPorphyrin biosynthesis protein [includes: uroporphyrin-III C-methyltransferase and uroporphyrinogen-III synthase; Belongs to the precorrin methyltransferase family. (486 aa)
CBO0922Conserved hypothetical protein. (60 aa)
hemBDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (324 aa)
cobBCobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (440 aa)
cobHPrecorrin-8x methylmutase. (208 aa)
CBO0928Putative phosphohydrolase. (202 aa)
CBO0929Conserved hypothetical protein. (122 aa)
CBO0930Similar to N-terminal regions of many MerR-family transcriptional regulators including Clostridium acetobutylicum transcriptional regulator, merr family cap0178 SWALL:Q97TD4 (EMBL:AE001438) (123 aa) fasta scores: E(): 0.00041, 36.97 38d in 119 aa. (424 aa)
CBO0931Putative acetyltransferase. (142 aa)
CBO0932Conserved hypothetical protein. (233 aa)
CBO0933Putative nitroreductase. (173 aa)
CBO0934Putative membrane protein. (103 aa)
CBO0935Conserved hypothetical protein. (177 aa)
cbiDCobalamin biosynthesis protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (359 aa)
cbiEPrecorrin-6y C5,15-methyltransferase [decarboxylating]. (216 aa)
CBO0938Putative membrane-associated CAAX amino terminal protease. (167 aa)
cbiTPrecorrin-8w decarboxylase. (191 aa)
CBO0940Putative exported protein. (143 aa)
CBO0941Putative membrane protein. (183 aa)
CBO0941APutative membrane protein. (104 aa)
CBO0942Putative membrane protein; No significant database matches. (73 aa)
CBO0943Putative membrane protein. (150 aa)
CBO0945Putative isochorismatase. (179 aa)
cbiLPrecorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. (238 aa)
cbiFPrecorrin-4 C11-methyltransferase. (254 aa)
cbiGPutative cobalamin biosynthesis protein. (350 aa)
cbiHPrecorrin-3b C17-methyltransferase. (243 aa)
cbiJPrecorrin-6x reductase. (255 aa)
CBO0951Probable transport protein. (162 aa)
cbiKCobalt chelatase. (260 aa)
pduXPropanediol utilization protein. (279 aa)
cobAcob(I)alamin adenosyltransferase. (173 aa)
CBO0955Crp-family transcriptional regulator. (235 aa)
nirCPutative nitrite transporter. (254 aa)
asrAAnaerobic sulfite reductase subunit A. (342 aa)
asrBAnaerobic sulfite reductase subunit B. (265 aa)
asrCAnaerobic sulfite reductase subunit c. (321 aa)
CBO0993APutative membrane protein. (100 aa)
CBO0996Putative rubrerythrin. (143 aa)
CBO1032Probable acetyltransferase. (145 aa)
norV-2Anaerobic nitric oxide reductase flavorubredoxin. (396 aa)
rbrPutative rubrerythrin. (195 aa)
cooSPutative oxidoreductase, acetyl-CoA synthase subunit. (628 aa)
CBO1332Putative oxidoreductase, electron transfer subunit. (147 aa)
CBO1333Putative oxidoreductase, NAD/FAD binding subunit. (408 aa)
CBO1340Conserved hypothetical protein. (111 aa)
CBO1341Putative iron-sulfur cluster binding protein. (425 aa)
CBO1546Putative glyoxalase. (120 aa)
CBO1658Signal-transduction and transcriptional-control protein (pseudogene); Large repeat genearted by the insertion of prophage. (210 aa)
CBO1659Conserved hypothetical protein. (184 aa)
CBO1674Putative dehydrogenase. (174 aa)
asrC-2Anaerobic sulfite reductase subunit C; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (284 aa)
ftnAFerritin; Iron-storage protein. (171 aa)
CBO1828Conserved hypothetical protein; Belongs to the UPF0145 family. (103 aa)
CBO1828AConserved hypothetical protein. (77 aa)
CBO1829Conserved hypothetical protein; Similar to the C-terminal region of several oxidoreductases such as Eubacterium acidaminophilum HymA protein. (80 aa)
CBO1830Putative hydrogenase; This CDS is also similar to CBO1832 (49.914 38d. in 579 aa overlap). (574 aa)
CBO1831Conserved hypothetical protein; Similar to the C-terminal region of stage II sporulation protein E from various organisms including Bacillus subtilis stage II sporulation protein eE SpoIIE or spoiih or bsu00640 SWALL:SP2E_BACSU (SWALL:P37475) (827 aa) fasta scores: E(): 0.0013, 27.01 38d in 211 aa. (389 aa)
CBO1832Putative hydrogenase; This CDS is also similar to CBO1830 (49.914 38d. in 579 aa overlap). (579 aa)
hypEHydrogenase isoenzymes formation protein. (334 aa)
hypDHydrogenase isoenzymes formation protein. (357 aa)
hypFHydrogenase maturation protein. (812 aa)
hypQ4Conserved hypothetical protein. (85 aa)
CBO1837Hypothetical protein; No significant database matches. (36 aa)
hypQ3Conserved hypothetical protein. (171 aa)
hupDPutative hydrogenase maturation protein. (138 aa)
hupLHydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (471 aa)
hupSHydrogenase small subunit. (290 aa)
CBO1969Conserved hypothetical protein. (271 aa)
CBO1970Putative cobalt ABC transporter, permease protein. (241 aa)
ccmA-4Putative cobalt ABC transporter, ATP-binding protein. (477 aa)
CBO1972Putative membrane protein. (188 aa)
codAPutative RNA methyltransferase (partial CDS); Partial CDS. Similar to C-terminal region of many RNA methyltransferases including Bacillus cereus tRNA (uracil-5-)-methyltransferase bc0364 SWALL:Q814A6 (EMBL:AE016999) (458 aa) fasta scores: E(): 1.6e-11,62.96 38d in 54 aa; was marked partial. (421 aa)
codBPutative cytosine permease. (423 aa)
CBO2074Hypothetical protein; No significant database hits. (50 aa)
CBO2075Conserved hypothetical protein. (374 aa)
CBO2076Hypothetical protein; No significant database hits. (52 aa)
CBO2207Pfam match to entry PF00903 Glyoxalase,Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 18.6, E-value 3.3e-05. (462 aa)
pdxAPutative 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (334 aa)
CBO2209Conserved hypothetical protein. (445 aa)
CBO2210DeoR family regulatory proteins. (252 aa)
cooS-2Putative carbon monoxide dehydrogenase beta subunit. (654 aa)
hypA-2Putative hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)
hypB-2Similar to the C-terminal region of Escherichia coli, and Escherichia coli O6 hydrogenase isoenzymes nickel incorporation protein HypB or b2727 or c3287 SWALL:HYPB_ECOLI (SWALL:P24190) (290 aa) fasta scores: E(): 3e-25, 42.99 38d in 207 aa. Similar to the full length Thermoanaerobacter tengcongensis Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase TTE0130 SWALL:Q8RDB1 (EMBL:AE012986) (218 aa) fasta scores: E(): 5.2e-25,44.66 38d in 206 aa. (212 aa)
thiM-2Conserved hypothetical protein (partial); Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (276 aa)
CBO2254Putative membrane protein; Similar to Enterococcus faecalis hypothetical protein EF2778 SWALL:Q830K3 (EMBL:AE016955) (176 aa) fasta scores: E(): 1.1e-25, 46.62 38d in 178 aa, and to Streptococcus pneumoniae conserved domain protein SP0723 SWALL:Q97RS0 (EMBL:AE007380) (174 aa) fasta scores: E(): 1.1e-22, 44.57 38d in 166 aa. CDS is extended at the C-terminus in comparison to orthologues. CDS feature contains an long overlap with the downstream CDS (CBO2253). Possible frameshift mutation after codon 158. (189 aa)
bioDPutative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (227 aa)
bioB-2Putative biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (318 aa)
CBO2260BioY family protein. (186 aa)
CBO2260APutative membrane protein. (109 aa)
CBO2261MarR family regulatory protein. (141 aa)
CBO2262Putative membrane protein. (198 aa)
CBO2263Metallopeptidase family M24 protein; Similar to an internal region of Homo sapiens xaa-Pro aminopeptidase 2 precursor XPNPEP2 SWALL:XPP2_HUMAN (SWALL:O43895) (674 aa) fasta scores: E(): 1.1e-58, 31.58 38d in 611 aa. Similar to full length Clostridium perfringens probable aminopeptidase CPE0872 SWALL:Q8XM18 (EMBL:AP003188) (591 aa) fasta scores: E(): 1.8e-101, 45.22 38d in 597 aa. (597 aa)
CBO2264Putative oligopeptide transporter. (465 aa)
fprA1Putative flavoprotein. (389 aa)
CBO2842Putative flavoprotein. (399 aa)
CBO2843acyl-CoA dehydrogenase. (635 aa)
CBO2854Putative transposase (partial); Gene remnant. Similar to an internal region of Bacillus licheniformis putative transposase SWALL:Q8VL62 (EMBL:AF459921) (286 aa) fasta scores: E(): 5.2e-05, 28.9 id in 128 aa; was marked partial. (223 aa)
CBO2855Hypothetical protein; No significant database matches. (83 aa)
CBO2904Gene remnat. Similar to an internal part of phage envelope glycoprotein; was marked partial. (763 aa)
thiCThiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (437 aa)
rubRubredoxin. (52 aa)
rbr3APutative rubrerythrin. (181 aa)
CBO3219Putative lipoprotein. (204 aa)
perRPutative oxidative stress regulatory protein; Belongs to the Fur family. (142 aa)
CBO3302Putative iron-dependent hydrogenase. (498 aa)
CBO3326Putative membrane protein. (181 aa)
CBO3333Desulfoferrodoxin. (124 aa)
CBO3334Conserved hypothetical protein. (64 aa)
CBO3341Putative ATP-dependent DNA helicase. (709 aa)
ftsH-2Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (658 aa)
ecfTABC transporter, permease protein; Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (267 aa)
ecfAABC transporter, ATP-binding protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (288 aa)
ecfA-2ABC transporter, ATP-binding protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (285 aa)
CBO3550Iron-only hydrogenase. (449 aa)
CBO3551Putative haloacid dehalogenase-like hydrolase. (214 aa)
CBO3552Conserved hypothetical protein. (132 aa)
CBO3578Conserved hypothetical protein. (501 aa)
CBO3579Putative dehydratase/lyase activating enzyme. (279 aa)
CBO3580Hypothetical protein; No significant database matches. (36 aa)
CBO3581Conserved hypothetical protein. (83 aa)
bioBBiotin synthase. (348 aa)
thiHThiazole biosynthesis protein. (458 aa)
hydFPutative ATP/GTP-binding protein. (399 aa)
CBO3614Acyl-acyl carrier protein thioesterase. (249 aa)
CBO3615Conserved hypothetical protein. (61 aa)
CBO3617Conserved hypothetical protein. (461 aa)
CBO3618Conserved hypothetical protein. (71 aa)
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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