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prdE prdE tadA tadA arcA1 arcA1 CBO0068 CBO0068 pyrG pyrG CBO0146 CBO0146 CBO0223 CBO0223 CBO0253 CBO0253 adeC adeC CBO0351 CBO0351 CBO0410 CBO0410 nadE nadE CBO0629 CBO0629 CBO0716 CBO0716 CBO0747 CBO0747 CBO0812 CBO0812 defA defA CBO0894 CBO0894 CBO0908 CBO0908 CBO0985 CBO0985 add add CBO1013 CBO1013 CBO1015 CBO1015 folD folD guaD guaD CBO1432 CBO1432 folE folE hisH hisH hisI hisI arcA2 arcA2 CBO1737 CBO1737 CBO1751 CBO1751 CBO1783 CBO1783 codA codA CBO2188 CBO2188 def-2 def-2 CBO2325 CBO2325 def-3 def-3 CBO2516 CBO2516 CBO2528 CBO2528 purL purL def def CBO2708 CBO2708 cheB cheB cheD cheD CBO2775 CBO2775 CBO2801 CBO2801 glsA glsA nagA nagA ribA ribA ribD ribD purH purH purN purN ssnA ssnA hydA hydA CBO2907 CBO2907 cdd cdd CBO3016 CBO3016 CBO3029 CBO3029 pdaA pdaA CBO3110 CBO3110 CBO3111 CBO3111 pdaB pdaB pyrC pyrC CBO3275 CBO3275 iadA iadA cwlD cwlD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
prdEPutative component of proline reductase. (156 aa)
tadAPutative cytosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (145 aa)
arcA1Arginine deiminase; Similar to Enterococcus faecalis arginine deiminase ArcA or ef0104 SWALL:Q93K67 (EMBL:AJ312276) (408 aa) fasta scores: E(): 1.6e-80, 55.06 38d in 405 aa, and to Bacillus licheniformis arginine deiminase ArcA SWALL:ARCA_BACLI (SWALL:O86131) (413 aa) fasta scores: E(): 3.7e-77, 51.22 id in 408 aa; Also similar to CBO1587 (57.03 38d). (403 aa)
CBO0068Similar to Clostridium tetani putative polysaccharide deacetylase ctc00229 SWALL:Q899F2 (EMBL:AE015936) (293 aa) fasta scores: E(): 4.7e-50,52.05 38d in 292 aa, and to Clostridium acetobutylicum predicted xylanase/chitin deacetilase, similar to yxkh b.subtilis cac0436 SWALL:Q97LW8 (EMBL:AE007558) (295 aa) fasta scores: E(): 8.6e-38, 47.03 38d in 253 aa. (289 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa)
CBO0146Putative zinc-binding protein; Similar to Clostridium tetani comE operon protein 2 ctc00309 SWALL:Q898X8 (EMBL:AE015936) (162 aa) fasta scores: E(): 6.7e-56, 81.48 38d in 162 aa, and to Clostridium acetobutylicum deoxycytidylate deaminase cac2876 SWALL:Q97F76 (EMBL:AE007785) (162 aa) fasta scores: E(): 1.9e-44, 67.28 38d in 162 aa. (162 aa)
CBO0223Similar to Bacillus subtilis probable polysaccharide deacetylase PdaA precursor PdaA or bsu07980 SWALL:PDAA_BACSU (SWALL:O34928) (263 aa) fasta scores: E(): 1.1e-13, 34.95 38d in 206 aa, and to Clostridium perfringens probable endo-1,4-beta-xylanase cpe1477 SWALL:Q8XKC3 (EMBL:AP003190) (238 aa) fasta scores: E(): 8.6e-33, 44.58 38d in 240 aa. (241 aa)
CBO0253Cytidine deaminase; Similar to Bacillus caldolyticus cytidine deaminase Cdd SWALL:Q9R2S1 (EMBL:AJ237979) (132 aa) fasta scores: E(): 1.2e-05, 30.4 38d in 125 aa, and to Aspergillus terreus blasticidin-S deaminase Bsd SWALL:BSD_ASPTE (SWALL:P78986) (130 aa) fasta scores: E(): 3.9e-05, 31.49 id in 127 aa. (125 aa)
adeCAdenine deaminase; Similar to Bacillus subtilis adenine deaminase AdeC or Ade or bsu14520 SWALL:ADEC_BACSU (SWALL:P39761) (577 aa) fasta scores: E(): 5e-63, 36.17 38d in 575 aa; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (599 aa)
CBO0351Probable polysaccharide deacetylase; Similar to Clostridium acetobutylicum predicted xylanase/chitin deacetylase cac2396 SWALL:Q97GH1 (EMBL:AE007739) (280 aa) fasta scores: E(): 3.1e-34, 45.6 id in 250 aa. (270 aa)
CBO0410Conserved hypothetical protein; Similar to Clostridium acetobutylicum cobyric acid synthase CobQ cac0961 SWALL:Q97KF8 (EMBL:AE007611) (243 aa) fasta scores: E(): 8.8e-72, 77.08 38d in 240 aa. (242 aa)
nadEGlutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (638 aa)
CBO0629N-carbamoyl-L-amino acid hydrolase. (407 aa)
CBO0716Putative transcriptional regulator (partial); Partial CDS. Similar to the C-terminal region of Clostridium tetani putative transcriptional regulatory protein ctc01439 SWALL:Q894U5 (EMBL:AE015941) (235 aa) fasta scores: E(): 2.1e-12, 41.81 38d in 110 aa; was marked partial. (86 aa)
CBO0747Putative phage related lysin (partial); Partial CDS. Similar to an internal region of Bacteriophage PL-1 N-acetylmuramoyl-L-alanine amidase lyS SWALL:Q9MCC6 (EMBL:AB035861) (350 aa) fasta scores: E(): 4.4e-05, 40 38d in 70 aa, and to Enterococcus faecalis enterolysin a enlA SWALL:Q9F8B0 (EMBL:AF249740) (343 aa) fasta scores: E(): 0.00024, 38.09 38d in 63 aa; was marked partial. (242 aa)
CBO0812Putative amidohydrolase. (389 aa)
defAPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (166 aa)
CBO0894Putative porphyromonas-type peptidyl-arginine deiminase; Belongs to the agmatine deiminase family. (410 aa)
CBO0908Hypothetical protein; No significant database matches. (568 aa)
CBO0985Conserved hypothetical protein. (107 aa)
addAdenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (335 aa)
CBO1013Putative cyclase. (181 aa)
CBO1015Putative cyclase. (192 aa)
folDPutative methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)
guaDGuanine deaminase. (157 aa)
CBO1432Putative N-acetylmuramoyl-L-alanine amidase. (283 aa)
folEPutative GTP cyclohydrolase I. (196 aa)
hisHImidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (110 aa)
arcA2Arginine deiminase; Also similar to CBO0065 (57.03 38d). (408 aa)
CBO1737Putative phage protein. (720 aa)
CBO1751Bacteriophage endolysin (N-acetylmuramoyl-L-alanine amidase); Also similar to CBO1653 (81.6 38d), CBO2325 (86.1 id.), CBO3016 (50.0 38d.). (253 aa)
CBO1783Putative mannosyl-glycoprotein endo-beta-N-acetylglucosamidase. (309 aa)
codAPutative RNA methyltransferase (partial CDS); Partial CDS. Similar to C-terminal region of many RNA methyltransferases including Bacillus cereus tRNA (uracil-5-)-methyltransferase bc0364 SWALL:Q814A6 (EMBL:AE016999) (458 aa) fasta scores: E(): 1.6e-11,62.96 38d in 54 aa; was marked partial. (421 aa)
CBO2188Amidohydrolase family protein. (450 aa)
def-2Putative peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (150 aa)
CBO2325Putative N-acetylmuramoyl-L-alanine amidase; Similar to the N-terminal region of Anabaena sp. hypothetical protein ALL1140 SWALL:Q8YXS1 (EMBL:AP003584) (313 aa) fasta scores: E(): 5.2e-30, 45.1 38d in 235 aa; Also similar to CBO1751 (81.16 38d), CBO1653 (77.4 id.), CBO3016 (47.6 38d.). (253 aa)
def-3Putative peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (147 aa)
CBO2516Putative L-asparaginase. (333 aa)
CBO2528Conserved hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. (239 aa)
purLFormylglycinamidine ribonucleotide synthetase. (1221 aa)
defPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (156 aa)
CBO2708Hypothetical protein; Note the database similarities are weak and only to the C-terminal region. (479 aa)
cheBChemotaxis response regulator protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (354 aa)
cheDChemotaxis protein CheD; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family. (162 aa)
CBO2775Probable polysaccharide deacetylase. (297 aa)
CBO2801Probable polysaccharide deacetylase. (243 aa)
glsAGlutaminase; Belongs to the glutaminase family. (305 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase. (378 aa)
ribA3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (401 aa)
ribDDiaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (365 aa)
purHBifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase. (499 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (205 aa)
ssnAPutative amidohydrolase. (442 aa)
hydAD-hydantoinase. (464 aa)
CBO2907Putative peptidase. (543 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (132 aa)
CBO3016N-acetylmuramoyl-L-alanine amidase; Also similar to the prophage encoded CDSs, CBO1751 (50 38d), CBO2325 (48.8 0d.), CBO1653 (55.5 0d.). (256 aa)
CBO3029Conserved hypothetical protein; Weakly similar to the upstream CDS CB03028. (449 aa)
pdaAProbable polysaccharide deacetylase. (324 aa)
CBO3110Putative N-acetylmuramoyl-L-alanine amidase; No significant database matches; similar to CBO3111 (42.304 38d. in 955 aa overlap). (949 aa)
CBO3111Putative N-acetylmuramoyl-L-alanine amidase; No significant database matches; similar to CBO3110 (42.304 38d. in 955 aa overlap). (967 aa)
pdaBProbable polysaccharide deacetylase. (250 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (396 aa)
CBO3275Conserved hypothetical protein. (667 aa)
iadAIsoaspartyl dipeptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. Belongs to the peptidase M38 family. (391 aa)
cwlDGermination-specific N-acetylmuramoyl-L-alanine amidase. (234 aa)
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
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