STRINGSTRING
bioB bioB CBO3579 CBO3579 CBO3557 CBO3557 CBO3554 CBO3554 act act nrdG nrdG CBO0106 CBO0106 CBO0202 CBO0202 splB splB ctpM ctpM nrdG-2 nrdG-2 CBO1067 CBO1067 CBO3064 CBO3064 queE queE hemZ hemZ CBO2992 CBO2992 hemN hemN CBO2955 CBO2955 cfr cfr CBO2630 CBO2630 rlmN rlmN CBO2453 CBO2453 rimO rimO miaB miaB bioB-2 bioB-2 CBO2075 CBO2075 CBO1997 CBO1997 CBO1982 CBO1982 CBO3184 CBO3184 moaA moaA thiH thiH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bioBBiotin synthase. (348 aa)
CBO3579Putative dehydratase/lyase activating enzyme. (279 aa)
CBO3557Putative radical SAM superfamily protein. (298 aa)
CBO3554Putative radical SAM superfamily protein. (310 aa)
actFormate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (232 aa)
nrdGAnaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (171 aa)
CBO0106Radical SAM superfamily protein; Similar to Clostridium tetani Fe-s oxidoreductase ctc00266 SWALL:Q899B9 (EMBL:AE015936) (460 aa) fasta scores: E(): 2.1e-137, 71.08 38d in 460 aa, and to Clostridium acetobutylicum moaa/nirj family fe-s oxidoreductase cac2791 SWALL:Q97FE9 (EMBL:AE007776) (461 aa) fasta scores: E(): 2.8e-119, 61.6 38d in 461 aa. (460 aa)
CBO0202Putative radical SAM protein; Similar to Clostridium perfringens hypothetical protein Cpe1196 cpe1196 SWALL:Q8XL46 (EMBL:AP003189) (662 aa) fasta scores: E(): 5.7e-150, 59.93 38d in 644 aa, and to Thermotoga maritima hypothetical protein Tm0337 tm0337 SWALL:Q9WYH2 (EMBL:AE001714) (558 aa) fasta scores: E(): 1.4e-99, 48.82 38d in 553 aa. (645 aa)
splBSimilar to Bacillus subtilis spore photoproduct lyase SplB or Spl or bsu13930 SWALL:SPL_BACSU (SWALL:P37956) (342 aa) fasta scores: E(): 1.4e-52, 45.23 id in 336 aa, and to Clostridium acetobutylicum spore photoproduct lyase, SplB cac0699 SWALL:Q97L63 (EMBL:AE007585) (336 aa) fasta scores: E(): 4.5e-71,54.92 38d in 335 aa. (335 aa)
ctpMPutative arylsulfatase regulatory protein. (450 aa)
nrdG-2Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (197 aa)
CBO1067Putative cofactor modifying protein. (292 aa)
CBO3064Putative radical SAM protein; Partially similar to Escherichia coli putative arylsulfatase regulatory protein AslB or AtsB or b3800 SWALL:ASLB_ECOLI (SWALL:P25550) (411 aa) fasta scores: E(): 0.02, 24.22 38d in 355 aa. (455 aa)
queEPutative radical SAM-superfamily protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (221 aa)
hemZPutative oxidase; Partly similar to Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN or b3867 SWALL:HEMN_ECOLI (SWALL:P32131) (457 aa) fasta scores: E(): 4.5e-11, 24.08 38d in 328 aa. (476 aa)
CBO2992Putative radical SAM superfamily protein. (617 aa)
hemNOxygen-independent coproporphyrinogen iii oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (383 aa)
CBO2955Putative radical SAM superfamily protein. (432 aa)
cfrPutative florfenicol resistance protein; Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics. (344 aa)
CBO2630Radical SAM superfamily protein. (559 aa)
rlmNRadical SAM superfamily protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (342 aa)
CBO2453Radical SAM superfamily protein. (363 aa)
rimORadical SAM superfamily protein; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (445 aa)
miaBPutative radical SAM superfamily protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (450 aa)
bioB-2Putative biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (318 aa)
CBO2075Conserved hypothetical protein. (374 aa)
CBO1997Putative radical SAM superfamily protein. (289 aa)
CBO1982Putative radical SAM superfamily protein. (326 aa)
CBO3184Putative pyruvate formate-lyase 2 activating enzyme. (252 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (319 aa)
thiHThiazole biosynthesis protein. (458 aa)
Your Current Organism:
Clostridium botulinum A ATCC 3502
NCBI taxonomy Id: 413999
Other names: C. botulinum A str. ATCC 3502, Clostridium botulinum A str. ATCC 3502, Clostridium botulinum A strain ATCC 3502
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.