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| | dna2 | DNA replication helicase/nuclease 2. (1406 aa) |
| | LOC111237687 | ATPase family AAA domain containing 5b. (887 aa) |
| | rad54b | RAD54 homolog B. (952 aa) |
| | Mcm9 | Uncharacterized protein. (108 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (625 aa) |
| | cdc6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (571 aa) |
| | orc1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (832 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (389 aa) |
| | msh5 | MutS homolog 5. (825 aa) |
| | telo2 | TEL2, telomere maintenance 2, homolog (S. cerevisiae). (840 aa) |
| | orc2 | Origin recognition complex, subunit 2. (594 aa) |
| | dbf4 | DBF4 zinc finger. (626 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1035 aa) |
| | atad5 | ATPase family AAA domain containing 5a. (1852 aa) |
| | msh4 | MutS homolog 4. (819 aa) |
| | gins3 | GINS complex subunit 3. (211 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (330 aa) |
| | pola1 | DNA polymerase. (1474 aa) |
| | cdc45 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (576 aa) |
| | chtf8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (106 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | msh3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1191 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa) |
| | mlh3 | MutL homolog 3 (E. coli). (1176 aa) |
| | gins1 | GINS complex subunit 1 (Psf1 homolog). (196 aa) |
| | mad2l2 | Mitotic arrest deficient 2 like 2. (210 aa) |
| | paxip1 | PAX interacting (with transcription-activation domain) protein 1. (1142 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (405 aa) |
| | timeless | Timeless circadian clock. (1255 aa) |
| | tdrd3 | Tudor domain containing 3. (787 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (815 aa) |
| | mlh1 | MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (743 aa) |
| | pms2 | PMS1 homolog 2, mismatch repair system component. (865 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (472 aa) |
| | msh6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1357 aa) |
| | rev1 | REV1 DNA directed polymerase. (1431 aa) |
| | Rbbp8 | SAE2 domain-containing protein. (86 aa) |
| | CDCA7L | zf-4CXXC_R1 domain-containing protein. (411 aa) |
| | pms1 | PMS1 homolog 1, mismatch repair system component. (921 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (815 aa) |
| | dmc1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa) |
| | rad51d | RAD51 paralog D. (333 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (635 aa) |
| | top3b | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (888 aa) |
| | rpa2 | Replication protein A2. (278 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa) |
| | ENSSDUP00000014088 | SCY domain-containing protein. (120 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa) |
| | rev3l | REV3 like, DNA directed polymerase zeta catalytic subunit. (2803 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1519 aa) |
| | xrcc2 | RECA_2 domain-containing protein. (308 aa) |
| | blm | BLM RecQ like helicase. (1392 aa) |
| | LOC111228832 | Zgc:110269. (344 aa) |
| | gmnn | Geminin DNA replication inhibitor. (215 aa) |
| | ENSSDUP00000015520 | BRCA2 DNA repair associated. (3048 aa) |
| | cdc7 | Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (472 aa) |
| | polh | Polymerase (DNA directed), eta. (690 aa) |
| | atm | Non-specific serine/threonine protein kinase. (2999 aa) |
| | ENSSDUP00000016000 | RPA_C domain-containing protein. (250 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2248 aa) |
| | pif1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (631 aa) |
| | ddx11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11. (896 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2076 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (457 aa) |
| | ENSSDUP00000018183 | RecQ helicase-like 4. (749 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (680 aa) |
| | bard1 | BRCA1 associated RING domain 1. (809 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | mcm10 | Minichromosome maintenance 10 replication initiation factor. (921 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa) |
| | fbh1 | F-box DNA helicase 1. (1016 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (526 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (430 aa) |
| | polk | Polymerase (DNA directed) kappa. (884 aa) |
| | msh2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa) |
| | cdt1 | Chromatin licensing and DNA replication factor 1. (534 aa) |
| | pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | rad1 | RAD1 homolog (S. pombe). (277 aa) |
| | recql5 | RecQ helicase-like 5. (1022 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (680 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (279 aa) |
| | dscc1 | DNA replication and sister chromatid cohesion 1. (390 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (343 aa) |
| | ENSSDUP00000023101 | FA complementation group M. (382 aa) |
| | pold1 | DNA polymerase. (1121 aa) |
| | chtf18 | CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae). (877 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | wdhd1 | WD repeat and HMG-box DNA binding protein 1. (1070 aa) |
| | mcm5 | DNA helicase; Belongs to the MCM family. (737 aa) |
| | orc3 | Origin recognition complex, subunit 3. (722 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | slf1 | SMC5-SMC6 complex localization factor 1. (857 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (861 aa) |
| | mcmbp | Minichromosome maintenance complex binding protein. (636 aa) |
| | rmi2 | RecQ mediated genome instability 2. (166 aa) |
| | rhno1 | Si:ch73-352p4.5. (262 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1045 aa) |
| | rad54l | RAD54 like. (740 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1488 aa) |
| | LOC111235454 | RAD51 paralog C. (351 aa) |
| | orc5 | Origin recognition complex, subunit 5. (445 aa) |
| | ENSSDUP00000027057 | Chromo_2 domain-containing protein. (702 aa) |
| | ENSSDUP00000027074 | Uncharacterized protein. (204 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (226 aa) |
| | CLSPN | Claspin. (1356 aa) |
| | mcm8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (846 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | lig1 | DNA ligase. (616 aa) |
| | atrip | Uncharacterized protein. (802 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (696 aa) |
| | cdca7 | Cell division cycle associated 7a. (401 aa) |
| | ENSSDUP00000029806 | DBF4-type domain-containing protein. (806 aa) |
| | brca1 | Uncharacterized protein. (1251 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (491 aa) |
| | exo1 | Exonuclease 1. (797 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (732 aa) |
| | poli | Polymerase (DNA directed) iota. (728 aa) |
| | rfc1 | Replication factor C subunit 1. (1181 aa) |
| | prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (423 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (359 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (387 aa) |
| | mcph1 | Microcephalin 1. (822 aa) |
| | MPHOSPH9 | M-phase phosphoprotein 9. (1290 aa) |
| | prim2 | DNA primase subunit 2. (592 aa) |
