STRINGSTRING
LOC111237687 LOC111237687 Mcm9 Mcm9 cdc6 cdc6 orc1 orc1 orc2 orc2 dbf4 dbf4 atad5 atad5 gins3 gins3 tipin tipin pola1 pola1 cdc45 cdc45 chtf8 chtf8 pcna pcna mcm7 mcm7 gins1 gins1 mad2l2 mad2l2 timeless timeless mcm6 mcm6 meiob meiob rev1 rev1 mcm3 mcm3 rad17 rad17 mcm2 mcm2 pold3 pold3 ENSSDUP00000014088 ENSSDUP00000014088 pole4 pole4 rev3l rev3l LOC111228832 LOC111228832 gmnn gmnn cdc7 cdc7 polh polh ddx11 ddx11 pole pole orc4 orc4 MCMDC2 MCMDC2 rfc3 rfc3 mcm10 mcm10 pole2 pole2 polk polk cdt1 cdt1 pola2 pola2 dscc1 dscc1 pold1 pold1 chtf18 chtf18 rfc5 rfc5 wdhd1 wdhd1 mcm5 mcm5 orc3 orc3 fen1 fen1 mcm4 mcm4 mcmbp mcmbp orc5 orc5 gins2 gins2 pole3 pole3 gins4 gins4 CLSPN CLSPN mcm8 mcm8 lig1 lig1 ENSSDUP00000029806 ENSSDUP00000029806 pold2 pold2 poli poli rfc1 rfc1 prim1 prim1 rfc4 rfc4 rfc2 rfc2 prim2 prim2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111237687ATPase family AAA domain containing 5b. (887 aa)
Mcm9Uncharacterized protein. (108 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (571 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (832 aa)
orc2Origin recognition complex, subunit 2. (594 aa)
dbf4DBF4 zinc finger. (626 aa)
atad5ATPase family AAA domain containing 5a. (1852 aa)
gins3GINS complex subunit 3. (211 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (330 aa)
pola1DNA polymerase. (1474 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (576 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (106 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
gins1GINS complex subunit 1 (Psf1 homolog). (196 aa)
mad2l2Mitotic arrest deficient 2 like 2. (210 aa)
timelessTimeless circadian clock. (1255 aa)
mcm6DNA helicase; Belongs to the MCM family. (815 aa)
meiobMethionine sulfoxide reductase B1b. (472 aa)
rev1REV1 DNA directed polymerase. (1431 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
rad17RAD17 checkpoint clamp loader component. (635 aa)
mcm2DNA helicase; Belongs to the MCM family. (888 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa)
ENSSDUP00000014088SCY domain-containing protein. (120 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
rev3lREV3 like, DNA directed polymerase zeta catalytic subunit. (2803 aa)
LOC111228832Zgc:110269. (344 aa)
gmnnGeminin DNA replication inhibitor. (215 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (472 aa)
polhPolymerase (DNA directed), eta. (690 aa)
ddx11DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11. (896 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2076 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (457 aa)
MCMDC2Minichromosome maintenance domain containing 2. (680 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (921 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (526 aa)
polkPolymerase (DNA directed) kappa. (884 aa)
cdt1Chromatin licensing and DNA replication factor 1. (534 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
pold1DNA polymerase. (1121 aa)
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae). (877 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
wdhd1WD repeat and HMG-box DNA binding protein 1. (1070 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
orc3Origin recognition complex, subunit 3. (722 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
mcm4DNA helicase; Belongs to the MCM family. (861 aa)
mcmbpMinichromosome maintenance complex binding protein. (636 aa)
orc5Origin recognition complex, subunit 5. (445 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (226 aa)
CLSPNClaspin. (1356 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (846 aa)
lig1DNA ligase. (616 aa)
ENSSDUP00000029806DBF4-type domain-containing protein. (806 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (491 aa)
poliPolymerase (DNA directed) iota. (728 aa)
rfc1Replication factor C subunit 1. (1181 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (423 aa)
rfc4Replication factor C (activator 1) 4. (359 aa)
rfc2Replication factor C (activator 1) 2. (387 aa)
prim2DNA primase subunit 2. (592 aa)
Your Current Organism:
Seriola dumerili
NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack
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