STRINGSTRING
dna2 dna2 exd2 exd2 rad51 rad51 msh5 msh5 RTEL1 RTEL1 msh4 msh4 msh3 msh3 mlh3 mlh3 paxip1 paxip1 rad9b rad9b tdrd3 tdrd3 mlh1 mlh1 pms2 pms2 msh6 msh6 Rbbp8 Rbbp8 CDCA7L CDCA7L pms1 pms1 dmc1 dmc1 rad51d rad51d top3b top3b rpa2 rpa2 topbp1 topbp1 xrcc2 xrcc2 blm blm ENSSDUP00000015520 ENSSDUP00000015520 atm atm ENSSDUP00000016000 ENSSDUP00000016000 rpa1 rpa1 atr atr pif1 pif1 rpa3 rpa3 ENSSDUP00000018183 ENSSDUP00000018183 bard1 bard1 rad9a rad9a fbh1 fbh1 rad52 rad52 msh2 msh2 rad1 rad1 recql5 recql5 RPA1 RPA1 hus1 hus1 xrcc3 xrcc3 slf1 slf1 rmi2 rmi2 rhno1 rhno1 top3a top3a tp53bp1 tp53bp1 LOC111235454 LOC111235454 ENSSDUP00000027057 ENSSDUP00000027057 ENSSDUP00000027074 ENSSDUP00000027074 rad50 rad50 atrip atrip mre11 mre11 cdca7 cdca7 brca1 brca1 exo1 exo1 rmi1 rmi1 mcph1 mcph1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dna2DNA replication helicase/nuclease 2. (1406 aa)
exd2Exonuclease 3'-5' domain containing 2. (625 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (389 aa)
msh5MutS homolog 5. (825 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1035 aa)
msh4MutS homolog 4. (819 aa)
msh3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1191 aa)
mlh3MutL homolog 3 (E. coli). (1176 aa)
paxip1PAX interacting (with transcription-activation domain) protein 1. (1142 aa)
rad9bRAD9 checkpoint clamp component B. (405 aa)
tdrd3Tudor domain containing 3. (787 aa)
mlh1MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (743 aa)
pms2PMS1 homolog 2, mismatch repair system component. (865 aa)
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1357 aa)
Rbbp8SAE2 domain-containing protein. (86 aa)
CDCA7Lzf-4CXXC_R1 domain-containing protein. (411 aa)
pms1PMS1 homolog 1, mismatch repair system component. (921 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
rad51dRAD51 paralog D. (333 aa)
top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa)
rpa2Replication protein A2. (278 aa)
topbp1DNA topoisomerase II binding protein 1. (1519 aa)
xrcc2RECA_2 domain-containing protein. (308 aa)
blmBLM RecQ like helicase. (1392 aa)
ENSSDUP00000015520BRCA2 DNA repair associated. (3048 aa)
atmNon-specific serine/threonine protein kinase. (2999 aa)
ENSSDUP00000016000RPA_C domain-containing protein. (250 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2248 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (631 aa)
rpa3Replication protein A3. (122 aa)
ENSSDUP00000018183RecQ helicase-like 4. (749 aa)
bard1BRCA1 associated RING domain 1. (809 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa)
fbh1F-box DNA helicase 1. (1016 aa)
rad52RAD52 homolog, DNA repair protein. (430 aa)
msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
rad1RAD1 homolog (S. pombe). (277 aa)
recql5RecQ helicase-like 5. (1022 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (680 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (279 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (343 aa)
slf1SMC5-SMC6 complex localization factor 1. (857 aa)
rmi2RecQ mediated genome instability 2. (166 aa)
rhno1Si:ch73-352p4.5. (262 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1045 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1488 aa)
LOC111235454RAD51 paralog C. (351 aa)
ENSSDUP00000027057Chromo_2 domain-containing protein. (702 aa)
ENSSDUP00000027074Uncharacterized protein. (204 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
atripUncharacterized protein. (802 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (696 aa)
cdca7Cell division cycle associated 7a. (401 aa)
brca1Uncharacterized protein. (1251 aa)
exo1Exonuclease 1. (797 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (732 aa)
mcph1Microcephalin 1. (822 aa)
Your Current Organism:
Seriola dumerili
NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack
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