120 items (Seriola dumerili) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111218364	Protein kinase, AMP-activated, gamma 3b non-catalytic subunit. (347 aa)
	fnip1	Folliculin interacting protein 1. (1304 aa)
	gabarap	GABA(A) receptor-associated protein b. (122 aa)
	LOC111225231	Microtubule-associated protein 1 light chain 3 beta. (126 aa)
	GABARAPL2	GABA type A receptor associated protein like 2. (121 aa)
	sesn1	Sestrin 1. (547 aa)
	nprl3	NPR3-like, GATOR1 complex subunit. (620 aa)
	map1lc3c	Microtubule-associated protein 1 light chain 3 gamma. (153 aa)
	LOC111228590	Protein kinase domain-containing protein. (677 aa)
	atg14	Autophagy related 14. (508 aa)
	dapl1	Death associated protein like 1. (116 aa)
	wipi2	WD repeat domain, phosphoinositide interacting 2. (427 aa)
	Szt2	Uncharacterized protein. (100 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (2386 aa)
	LOC111232723	Si:zfos-80g12.1. (444 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (695 aa)
	xbp1	X-box binding protein 1. (264 aa)
	MAP1LC3A	Microtubule-associated protein 1 light chain 3 alpha. (121 aa)
	LOC111236271	WD repeat domain, phosphoinositide interacting 1. (435 aa)
	cunh12orf66	Si:ch211-125a15.1. (449 aa)
	LOC111219302	Si:ch211-117c9.1. (717 aa)
	itfg2	Integrin alpha FG-GAP repeat containing 2. (473 aa)
	atg7	ATG7 autophagy related 7 homolog (S. cerevisiae). (720 aa)
	JMY-2	Junction mediating and regulatory protein, p53 cofactor. (612 aa)
	clec16a	C-type lectin domain containing 16A. (1158 aa)
	LOC111222359	Protein phosphatase, Mg2+/Mn2+ dependent, 1Db. (566 aa)
	LOC111216358	Si:ch211-153j24.3. (376 aa)
	pick1	Protein interacting with prkca 1. (416 aa)
	LOC111234619	Ras-related GTP binding A. (315 aa)
	LOC111235178	Uncharacterized protein. (438 aa)
	LOC111216707	Activating transcription factor 4a. (459 aa)
	wdr45b	WD repeat domain 45B. (344 aa)
	LOC111232820	Si:ch211-11n16.2. (655 aa)
	mios	Missing oocyte, meiosis regulator, homolog (Drosophila). (876 aa)
	ENSSDUP00000015254	Uncharacterized protein. (531 aa)
	rnf152	Ring finger protein 152. (168 aa)
	rragc	Ras-related GTP binding Ca. (382 aa)
	rrp8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (564 aa)
	LOC111236887	BH4_2 domain-containing protein. (225 aa)
	LOC111232129	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (448 aa)
	LOC111237627	Zinc finger, FYVE domain containing 1. (721 aa)
	ENSSDUP00000013826	Uncharacterized protein. (299 aa)
	ENSSDUP00000013772	Protein kinase domain-containing protein. (155 aa)
	LOC111235829	Zinc finger CCCH-type containing 12A. (625 aa)
	JMY	Junction mediating and regulatory protein, p53 cofactor. (768 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1660 aa)
	LOC111226573	Cytoplasmic polyadenylation element binding protein 4a. (747 aa)
	nuak2	NUAK family, SNF1-like kinase, 2. (630 aa)
	vps41	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (853 aa)
	LOC111223488	Sestrin 2. (556 aa)
	flcn	Folliculin. (559 aa)
	atf3	Activating transcription factor 3. (317 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (573 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1017 aa)
	ENSSDUP00000010976	Uncharacterized protein. (205 aa)
	srebf1	Sterol regulatory element binding transcription factor 1. (1223 aa)
	LOC111238978	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (297 aa)
	bcl2	BCL2 apoptosis regulator b. (228 aa)
	wdr59	WD repeat domain 59. (973 aa)
	prkag1	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (306 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (875 aa)
	LOC111230596	Si:dkey-206d17.12. (638 aa)
	LOC111223691	Si:dkey-16p21.7. (707 aa)
	ENSSDUP00000008886	Uncharacterized protein. (143 aa)
	seh1l	SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (383 aa)
	pcsk9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (668 aa)
	impact	Impact RWD domain protein. (323 aa)
	nuak1	NUAK family, SNF1-like kinase, 1b. (661 aa)
	LOC111219981	Protein kinase domain-containing protein. (866 aa)
	bmt2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (962 aa)
	hspa5	Heat shock protein 5; Belongs to the heat shock protein 70 family. (654 aa)
	wdr45	WD repeat domain 45. (358 aa)
	ENSSDUP00000008522	Uncharacterized protein. (122 aa)
	ttc5	Tetratricopeptide repeat domain 5. (444 aa)
	gas6	Uncharacterized protein. (650 aa)
	lamp2	Lysosomal-associated membrane protein 2. (419 aa)
	bhlha15	Basic helix-loop-helix family, member a15. (189 aa)
	LOC111218548	Salt-inducible kinase 1. (805 aa)
	gcn1	GCN1 activator of EIF2AK4. (2471 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2405 aa)
	ZFYVE1	Zinc finger FYVE-type containing 1. (786 aa)
	dap	Death-associated protein. (104 aa)
	WIPI1	WD repeat domain, phosphoinositide interacting 1. (443 aa)
	depdc5	DEP domain containing 5. (1534 aa)
	eif2s1	Eukaryotic translation initiation factor 2, subunit 1 alpha b. (330 aa)
	LOC111225357	Uncharacterized protein. (627 aa)
	LOC111233823	Xenotropic and polytropic retrovirus receptor 1b. (691 aa)
	rptor	Regulatory associated protein of MTOR, complex 1. (1350 aa)
	fbxo22	F-box protein 22. (387 aa)
	LOC111238835	GABA(A) receptor-associated protein like 2. (126 aa)
	ENSSDUP00000004798	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1173 aa)
	ENSSDUP00000003898	Uncharacterized protein. (697 aa)
	nprl2	NPR2 like, GATOR1 complex subunit. (381 aa)
	ENSSDUP00000000970	Reverse transcriptase domain-containing protein. (566 aa)
	LOC111240185	Xenotropic and polytropic retrovirus receptor 1a. (695 aa)
	LOC111230826	COBW domain containing. (430 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (612 aa)
	ENSSDUP00000003865	Uncharacterized protein. (665 aa)
	ENSSDUP00000003789	Eukaryotic translation initiation factor 2-alpha kinase 2. (701 aa)
	nim1k	NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (475 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1107 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ENSSDUP00000003145	Uncharacterized protein. (158 aa)
	LOC111221217	Si:ch211-22d5.2; Belongs to the protein kinase superfamily. (433 aa)
	wdr24	WD repeat domain 24. (789 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2575 aa)
	tbl2	Transducin (beta)-like 2. (441 aa)
	LOC111221652	Transcription factor EB. (513 aa)
	ambra1	Autophagy/beclin-1 regulator 1b. (1380 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (557 aa)
	ppm1d	Protein phosphatase, Mg2+/Mn2+ dependent, 1Da. (568 aa)
	ENSSDUP00000030247	Reverse transcriptase domain-containing protein. (300 aa)
	LOC111238725	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit. (332 aa)
	becn1	Beclin 1, autophagy related. (447 aa)
	LOC111226203	Ras-related GTP binding D. (390 aa)
	sik2	Salt-inducible kinase 2b. (933 aa)
	lars1	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family. (1184 aa)
	pik3r4	Phosphoinositide-3-kinase, regulatory subunit 4. (1337 aa)
	LOC111223137	Uncharacterized protein. (382 aa)
	kptn	Kaptin (actin binding protein). (439 aa)

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK4	ENSSDUP00000003789	ENSSDUP00000013335	ENSSDUP00000003789	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2-alpha kinase 2.	0.435
EIF2AK4	ENSSDUP00000003865	ENSSDUP00000013335	ENSSDUP00000003865	Eukaryotic translation initiation factor 2 alpha kinase 4.	Uncharacterized protein.	0.435
EIF2AK4	ENSSDUP00000003898	ENSSDUP00000013335	ENSSDUP00000003898	Eukaryotic translation initiation factor 2 alpha kinase 4.	Uncharacterized protein.	0.435
EIF2AK4	LOC111216707	ENSSDUP00000013335	ENSSDUP00000018143	Eukaryotic translation initiation factor 2 alpha kinase 4.	Activating transcription factor 4a.	0.581
EIF2AK4	LOC111234619	ENSSDUP00000013335	ENSSDUP00000019968	Eukaryotic translation initiation factor 2 alpha kinase 4.	Ras-related GTP binding A.	0.485
EIF2AK4	eif2ak3	ENSSDUP00000013335	ENSSDUP00000003566	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2-alpha kinase 3.	0.569
EIF2AK4	eif2s1	ENSSDUP00000013335	ENSSDUP00000005237	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2, subunit 1 alpha b.	0.995
EIF2AK4	gcn1	ENSSDUP00000013335	ENSSDUP00000006877	Eukaryotic translation initiation factor 2 alpha kinase 4.	GCN1 activator of EIF2AK4.	0.849
EIF2AK4	hspa5	ENSSDUP00000013335	ENSSDUP00000032656	Eukaryotic translation initiation factor 2 alpha kinase 4.	Heat shock protein 5; Belongs to the heat shock protein 70 family.	0.466
EIF2AK4	impact	ENSSDUP00000013335	ENSSDUP00000031499	Eukaryotic translation initiation factor 2 alpha kinase 4.	Impact RWD domain protein.	0.500
EIF2AK4	lars1	ENSSDUP00000013335	ENSSDUP00000029394	Eukaryotic translation initiation factor 2 alpha kinase 4.	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.666
EIF2AK4	mtor	ENSSDUP00000013335	ENSSDUP00000002870	Eukaryotic translation initiation factor 2 alpha kinase 4.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.655
EIF2AK4	nfe2l2	ENSSDUP00000013335	ENSSDUP00000000473	Eukaryotic translation initiation factor 2 alpha kinase 4.	Nuclear factor, erythroid 2-like 2a.	0.910
EIF2AK4	rptor	ENSSDUP00000013335	ENSSDUP00000005043	Eukaryotic translation initiation factor 2 alpha kinase 4.	Regulatory associated protein of MTOR, complex 1.	0.565
EIF2AK4	sirt1	ENSSDUP00000013335	ENSSDUP00000024624	Eukaryotic translation initiation factor 2 alpha kinase 4.	Deacetylase sirtuin-type domain-containing protein.	0.435
EIF2AK4	xbp1	ENSSDUP00000013335	ENSSDUP00000024540	Eukaryotic translation initiation factor 2 alpha kinase 4.	X-box binding protein 1.	0.609
ENSSDUP00000000970	ENSSDUP00000008886	ENSSDUP00000000970	ENSSDUP00000008886	Reverse transcriptase domain-containing protein.	Uncharacterized protein.	0.442
ENSSDUP00000003145	ENSSDUP00000008886	ENSSDUP00000003145	ENSSDUP00000008886	Uncharacterized protein.	Uncharacterized protein.	0.452
ENSSDUP00000003789	EIF2AK4	ENSSDUP00000003789	ENSSDUP00000013335	Eukaryotic translation initiation factor 2-alpha kinase 2.	Eukaryotic translation initiation factor 2 alpha kinase 4.	0.435
ENSSDUP00000003789	eif2s1	ENSSDUP00000003789	ENSSDUP00000005237	Eukaryotic translation initiation factor 2-alpha kinase 2.	Eukaryotic translation initiation factor 2, subunit 1 alpha b.	0.987