(38 nodes) snRNA binding network (Seriola dumerili)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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Your Input:
	snrpc	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (182 aa)
	snrnp70	Small nuclear ribonucleoprotein 70 (U1). (485 aa)
	ncbp2	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (164 aa)
	mettl16	U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (563 aa)
	snrpb2	Small nuclear ribonucleoprotein polypeptide B2. (218 aa)
	sf3b3	Splicing factor 3b, subunit 3. (1217 aa)
	prpf4	PRP4 pre-mRNA processing factor 4 homolog (yeast). (514 aa)
	hexim1	HEXIM P-TEFb complex subunit 1. (364 aa)
	LOC111219616	Uncharacterized protein. (182 aa)
	eftud2	Elongation factor Tu GTP binding domain containing 2. (971 aa)
	coil	Coilin p80. (536 aa)
	toe1	Target of EGR1, exonuclease. (524 aa)
	snrpa1	Small nuclear ribonucleoprotein polypeptide A. (289 aa)
	sart3	Spliceosome associated factor 3, U4/U6 recycling protein. (1020 aa)
	lrmda	Leucine rich melanocyte differentiation associated. (266 aa)
	LOC111222774	Cyclin T2b; Belongs to the cyclin family. (556 aa)
	LOC111218225	Cyclin T2; Belongs to the cyclin family. (765 aa)
	lsm11	LSM11, U7 small nuclear RNA associated. (342 aa)
	lsm4	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (167 aa)
	ro60	Ro60, Y RNA binding protein. (542 aa)
	rbm41	RNA binding motif protein 41. (439 aa)
	prpf31	PRP31 pre-mRNA processing factor 31 homolog (yeast). (508 aa)
	LOC111234431	Methylphosphate capping enzyme. (740 aa)
	LSM10	LSM10, U7 small nuclear RNA associated. (123 aa)
	larp7	La ribonucleoprotein domain family, member 7. (564 aa)
	snrpd3	Small nuclear ribonucleoprotein Sm D3. (127 aa)
	ENSSDUP00000009098	Uncharacterized protein. (308 aa)
	rnpc3	RNA-binding region (RNP1, RRM) containing 3. (513 aa)
	LOC111240082	Bin3-type SAM domain-containing protein. (533 aa)
	lsm3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (114 aa)
	ccnt1	Cyclin T1; Belongs to the cyclin family. (700 aa)
	gemin5	Gem (nuclear organelle) associated protein 5. (1443 aa)
	snu13	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
	rbm22	RNA binding motif protein 22. (465 aa)
	prpf8	Pre-mRNA processing factor 8. (2338 aa)
	LOC111224130	Leucine rich repeat containing 51. (179 aa)
	rbmx	RNA binding motif protein X-linked. (429 aa)
	snrpa	Small nuclear ribonucleoprotein polypeptide A. (282 aa)

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSDUP00000009098	LOC111218225	ENSSDUP00000009098	ENSSDUP00000014397	Uncharacterized protein.	Cyclin T2; Belongs to the cyclin family.	0.642
ENSSDUP00000009098	LOC111222774	ENSSDUP00000009098	ENSSDUP00000014993	Uncharacterized protein.	Cyclin T2b; Belongs to the cyclin family.	0.642
ENSSDUP00000009098	LOC111234431	ENSSDUP00000009098	ENSSDUP00000011288	Uncharacterized protein.	Methylphosphate capping enzyme.	0.596
ENSSDUP00000009098	LOC111240082	ENSSDUP00000009098	ENSSDUP00000008748	Uncharacterized protein.	Bin3-type SAM domain-containing protein.	0.596
ENSSDUP00000009098	ccnt1	ENSSDUP00000009098	ENSSDUP00000007497	Uncharacterized protein.	Cyclin T1; Belongs to the cyclin family.	0.721
ENSSDUP00000009098	larp7	ENSSDUP00000009098	ENSSDUP00000009600	Uncharacterized protein.	La ribonucleoprotein domain family, member 7.	0.779
LOC111218225	ENSSDUP00000009098	ENSSDUP00000014397	ENSSDUP00000009098	Cyclin T2; Belongs to the cyclin family.	Uncharacterized protein.	0.642
LOC111218225	hexim1	ENSSDUP00000014397	ENSSDUP00000031370	Cyclin T2; Belongs to the cyclin family.	HEXIM P-TEFb complex subunit 1.	0.642
LOC111218225	larp7	ENSSDUP00000014397	ENSSDUP00000009600	Cyclin T2; Belongs to the cyclin family.	La ribonucleoprotein domain family, member 7.	0.695
LOC111218225	ncbp2	ENSSDUP00000014397	ENSSDUP00000021219	Cyclin T2; Belongs to the cyclin family.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.481
LOC111219616	LSM10	ENSSDUP00000031441	ENSSDUP00000009651	Uncharacterized protein.	LSM10, U7 small nuclear RNA associated.	0.786
LOC111219616	eftud2	ENSSDUP00000031441	ENSSDUP00000031558	Uncharacterized protein.	Elongation factor Tu GTP binding domain containing 2.	0.838
LOC111219616	lsm3	ENSSDUP00000031441	ENSSDUP00000008229	Uncharacterized protein.	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.632
LOC111219616	lsm4	ENSSDUP00000031441	ENSSDUP00000013196	Uncharacterized protein.	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.774
LOC111219616	ncbp2	ENSSDUP00000031441	ENSSDUP00000021219	Uncharacterized protein.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.778
LOC111219616	prpf31	ENSSDUP00000031441	ENSSDUP00000011495	Uncharacterized protein.	PRP31 pre-mRNA processing factor 31 homolog (yeast).	0.774
LOC111219616	prpf4	ENSSDUP00000031441	ENSSDUP00000030654	Uncharacterized protein.	PRP4 pre-mRNA processing factor 4 homolog (yeast).	0.559
LOC111219616	prpf8	ENSSDUP00000031441	ENSSDUP00000004138	Uncharacterized protein.	Pre-mRNA processing factor 8.	0.815
LOC111219616	rbm22	ENSSDUP00000031441	ENSSDUP00000005239	Uncharacterized protein.	RNA binding motif protein 22.	0.533
LOC111219616	rbm41	ENSSDUP00000031441	ENSSDUP00000012096	Uncharacterized protein.	RNA binding motif protein 41.	0.774