(102 nodes) Regulation of MAP kinase activity network (Seriola dumerili)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111223516	Tribbles pseudokinase 1. (362 aa)
	LOC111217813	3-hydroxy-3-methylglutaryl coenzyme A reductase. (883 aa)
	LOC111239442	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (196 aa)
	LOC111226155	Fibroblast growth factor receptor. (831 aa)
	ENSSDUP00000029748	Protein kinase domain-containing protein. (123 aa)
	LOC111219382	Tribbles pseudokinase 3. (355 aa)
	il34	Interleukin 34. (217 aa)
	pik3r5	Phosphoinositide-3-kinase, regulatory subunit 5. (895 aa)
	LOC111227984	Interleukin-1. (262 aa)
	LOC111223087	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (386 aa)
	ptpn5	Protein tyrosine phosphatase non-receptor type 5. (407 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (479 aa)
	PAQR3	Progestin and adipoQ receptor family member IIIb. (315 aa)
	CAV3-2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	LOC111227981	Interleukin-1. (264 aa)
	spry4	Sprouty homolog 4 (Drosophila). (294 aa)
	LOC111234449	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	sorl1	Sortilin-related receptor, L(DLR class) A repeats containing. (2236 aa)
	tsg101	Tumor susceptibility 101a. (390 aa)
	ENSSDUP00000026339	UEV domain-containing protein. (100 aa)
	paqr3	Progestin and adipoQ receptor family member IIIa. (342 aa)
	axin1	Axin 1. (869 aa)
	ENSSDUP00000025073	Interleukin-1 receptor-associated kinase 3. (336 aa)
	LOC111234739	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1112 aa)
	LOC111230347	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (529 aa)
	LOC111218446	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (294 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (871 aa)
	sash1	SAM and SH3 domain containing 1a. (1192 aa)
	map3k13	Mitogen-activated protein kinase kinase kinase. (1017 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (449 aa)
	LOC111222913	Transforming growth factor, alpha. (258 aa)
	LOC111216736	Endoplasmic reticulum to nucleus signaling 2. (982 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (461 aa)
	ENSSDUP00000022124	Si:dkey-175m17.7. (886 aa)
	ENSSDUP00000021856	Uncharacterized protein. (140 aa)
	pik3cg	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1122 aa)
	LOC111235997	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	hgs	Hepatocyte growth factor-regulated tyrosine kinase substrate. (766 aa)
	LOC111216635	Uncharacterized protein. (888 aa)
	LOC111223895	Dual specificity phosphatase 19b. (203 aa)
	p2rx7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (580 aa)
	ENSSDUP00000018537	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (199 aa)
	LOC111216519	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (565 aa)
	dkk1	Dickkopf WNT signaling pathway inhibitor 1a. (297 aa)
	LOC111225301	Programmed cell death 10b. (210 aa)
	LOC111237969	Dual specificity phosphatase 19a. (213 aa)
	ENSSDUP00000017003	Uncharacterized protein. (481 aa)
	ENSSDUP00000016996	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (127 aa)
	ENSSDUP00000016974	Uncharacterized protein. (226 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	LOC111239113	Programmed cell death 10a. (212 aa)
	nek10	NIMA-related kinase 10. (1063 aa)
	LOC111222720	Sprouty RTK signaling antagonist 2. (353 aa)
	LOC111226769	Teneurin transmembrane protein 1. (2696 aa)
	Dtnbp1	Dystrobrevin binding protein 1b. (220 aa)
	LOC111220854	Tumor necrosis factor a (TNF superfamily, member 2). (250 aa)
	tpd52l1	Tpd52 like 1. (272 aa)
	fzd5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	LOC111221167	Protein tyrosine phosphatase receptor type C. (1252 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (207 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (504 aa)
	LOC111227716	3-hydroxy-3-methylglutaryl coenzyme A reductase. (886 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (602 aa)
	ern1	Endoplasmic reticulum to nucleus signaling 1. (1096 aa)
	LOC111240400	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (168 aa)
	LOC111235735	Apolipoprotein Eb. (276 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (322 aa)
	trib2	Tribbles pseudokinase 2. (345 aa)
	LOC111225549	SAM and SH3 domain containing 1b. (974 aa)
	ENSSDUP00000010765	Uncharacterized protein. (574 aa)
	ENSSDUP00000010763	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (587 aa)
	Nf1	Uncharacterized protein. (620 aa)
	LOC111232662	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (151 aa)
	spry1	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (362 aa)
	LOC111230606	Uncharacterized protein. (259 aa)
	LOC111231614	Uncharacterized protein. (925 aa)
	edn1	Endothelin 1. (187 aa)
	gba	Glucosylceramidase. (522 aa)
	ajuba	Ajuba LIM protein. (729 aa)
	LOC111226537	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (158 aa)
	LOC111238903	Bone morphogenetic protein 16. (434 aa)
	tmem130	Transmembrane protein 130. (314 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (462 aa)
	LOC111238877	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (413 aa)
	fzd8	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2405 aa)
	LOC111234934	CD40 molecule, TNF receptor superfamily member 5. (364 aa)
	ENSSDUP00000005311	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (490 aa)
	aida	Axin interactor, dorsalization associated. (307 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (602 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (364 aa)
	LOC111216899	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	sh2b3	SH2B adaptor protein 3. (758 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
	nox4	FAD-binding FR-type domain-containing protein. (533 aa)
	LOC111224124	Uncharacterized protein. (340 aa)
	ENSSDUP00000000421	Uncharacterized protein. (100 aa)
	map3k4	Mitogen-activated protein kinase kinase kinase 4. (1588 aa)

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV3	CAV3-2	ENSSDUP00000016971	ENSSDUP00000027143	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.466
CAV3	ENSSDUP00000016996	ENSSDUP00000016971	ENSSDUP00000016996	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.543
CAV3-2	CAV3	ENSSDUP00000027143	ENSSDUP00000016971	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.466
ENSSDUP00000005311	LOC111218446	ENSSDUP00000005311	ENSSDUP00000024768	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.988
ENSSDUP00000005311	LOC111220854	ENSSDUP00000005311	ENSSDUP00000015422	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator.	Tumor necrosis factor a (TNF superfamily, member 2).	0.563
ENSSDUP00000005311	LOC111234934	ENSSDUP00000005311	ENSSDUP00000006151	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator.	CD40 molecule, TNF receptor superfamily member 5.	0.576
ENSSDUP00000010763	LOC111224124	ENSSDUP00000010763	ENSSDUP00000000745	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.675
ENSSDUP00000010763	sfrp2	ENSSDUP00000010763	ENSSDUP00000024693	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled-related protein 2.	0.675
ENSSDUP00000010765	Nf1	ENSSDUP00000010765	ENSSDUP00000010667	Uncharacterized protein.	Uncharacterized protein.	0.943
ENSSDUP00000016974	ENSSDUP00000017003	ENSSDUP00000016974	ENSSDUP00000017003	Uncharacterized protein.	Uncharacterized protein.	0.849
ENSSDUP00000016996	CAV3	ENSSDUP00000016996	ENSSDUP00000016971	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.543
ENSSDUP00000017003	ENSSDUP00000016974	ENSSDUP00000017003	ENSSDUP00000016974	Uncharacterized protein.	Uncharacterized protein.	0.849
ENSSDUP00000018537	LOC111216519	ENSSDUP00000018537	ENSSDUP00000018222	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family.	0.973
ENSSDUP00000018537	LOC111226155	ENSSDUP00000018537	ENSSDUP00000031795	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family.	Fibroblast growth factor receptor.	0.699
ENSSDUP00000018537	LOC111230347	ENSSDUP00000018537	ENSSDUP00000024810	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.	0.746
ENSSDUP00000018537	pdgfc	ENSSDUP00000018537	ENSSDUP00000001886	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family.	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family.	0.973
ENSSDUP00000022124	map2k7	ENSSDUP00000022124	ENSSDUP00000027268	Si:dkey-175m17.7.	Mitogen-activated protein kinase kinase 7.	0.521
ENSSDUP00000025073	LOC111220854	ENSSDUP00000025073	ENSSDUP00000015422	Interleukin-1 receptor-associated kinase 3.	Tumor necrosis factor a (TNF superfamily, member 2).	0.452
ENSSDUP00000025073	LOC111227981	ENSSDUP00000025073	ENSSDUP00000026814	Interleukin-1 receptor-associated kinase 3.	Interleukin-1.	0.473
ENSSDUP00000025073	LOC111227984	ENSSDUP00000025073	ENSSDUP00000027517	Interleukin-1 receptor-associated kinase 3.	Interleukin-1.	0.473