Your Input: | |
| | ENSSDUP00000018853 | Endo/exonuclease/phosphatase domain-containing protein. (404 aa) |
| | polm | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (535 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (311 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (387 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (359 aa) |
| | rfc1 | Replication factor C subunit 1. (1181 aa) |
| | polq | Polymerase (DNA directed), theta. (2105 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (732 aa) |
| | uimc1 | RAP80_UIM domain-containing protein. (1088 aa) |
| | exo1 | Exonuclease 1. (797 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (491 aa) |
| | cnppd1 | Cyclin Pas1/PHO80 domain containing 1. (435 aa) |
| | brca1 | Uncharacterized protein. (1251 aa) |
| | ENSSDUP00000029876 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa) |
| | poll | Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (567 aa) |
| | cdca7 | Cell division cycle associated 7a. (401 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (696 aa) |
| | atrip | Uncharacterized protein. (802 aa) |
| | ENSSDUP00000029566 | Histone H2B; Belongs to the histone H2B family. (114 aa) |
| | LOC111237550 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | baz1b | Bromodomain adjacent to zinc finger domain, 1B. (1656 aa) |
| | ENSSDUP00000001025 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | ENSSDUP00000001040 | Uncharacterized protein; Belongs to the histone H2B family. (67 aa) |
| | EME2 | ERCC4 domain-containing protein. (378 aa) |
| | ppp5c | Serine/threonine-protein phosphatase. (491 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (625 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (389 aa) |
| | LOC111235132 | Ubiquitin-conjugating enzyme E2 variant 1. (147 aa) |
| | Brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (280 aa) |
| | sirt7 | Sirtuin 7. (407 aa) |
| | ube2i | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (175 aa) |
| | sumo2 | Small ubiquitin-related modifier. (95 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (330 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | rps27a | Ribosomal protein S27a. (156 aa) |
| | LOC111223631 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (274 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (560 aa) |
| | paxip1 | PAX interacting (with transcription-activation domain) protein 1. (1142 aa) |
| | nsd2 | Nuclear receptor binding SET domain protein 2. (1337 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (461 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (405 aa) |
| | timeless | Timeless circadian clock. (1255 aa) |
| | tdrd3 | Tudor domain containing 3. (787 aa) |
| | abl1 | Tyrosine-protein kinase. (1118 aa) |
| | ENSSDUP00000006700 | Ring finger protein 168. (397 aa) |
| | ENSSDUP00000006905 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa) |
| | LOC111221313 | Histone H2B; Belongs to the histone H2B family. (123 aa) |
| | ENSSDUP00000007129 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | ENSSDUP00000007300 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (90 aa) |
| | pias4 | Protein inhibitor of activated STAT, 4a. (507 aa) |
| | ENSSDUP00000007804 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (472 aa) |
| | LOC111224648 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | prkdc | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3939 aa) |
| | dna2 | DNA replication helicase/nuclease 2. (1406 aa) |
| | ENSSDUP00000000054 | Histone H2B; Belongs to the histone H2B family. (131 aa) |
| | rad51ap1 | RAD51 associated protein 1. (329 aa) |
| | rnf169 | Ring finger protein 169. (597 aa) |
| | ENSSDUP00000008454 | Reverse transcriptase domain-containing protein. (1306 aa) |
| | pold4 | Si:dkey-28b4.7. (108 aa) |
| | LOC111224285 | X-ray repair complementing defective repair in Chinese hamster cells 4. (338 aa) |
| | parp2 | Poly [ADP-ribose] polymerase. (659 aa) |
| | tmem182 | Transmembrane protein 182a. (239 aa) |
| | Rbbp8 | SAE2 domain-containing protein. (86 aa) |
| | CDCA7L | zf-4CXXC_R1 domain-containing protein. (411 aa) |
| | ubb | Uncharacterized protein. (153 aa) |
| | ankrd11 | Ankyrin repeat domain 11. (2846 aa) |
| | eya3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (604 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | xrcc6 | X-ray repair complementing defective repair in Chinese hamster cells 6. (610 aa) |
| | LOC111230935 | Lysine (K)-specific demethylase 4B. (1235 aa) |
| | sumo1 | Small ubiquitin-related modifier. (101 aa) |
| | ccna2 | Cyclin A2; Belongs to the cyclin family. (437 aa) |
| | lig3 | DNA ligase. (1013 aa) |
| | rad51d | RAD51 paralog D. (333 aa) |
| | ankrd12 | Ankyrin repeat domain 12. (1958 aa) |
| | tdp1 | Tyrosyl-DNA phosphodiesterase 1. (621 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (635 aa) |
| | ENSSDUP00000012931 | ANK_REP_REGION domain-containing protein. (674 aa) |
| | slx4 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1705 aa) |
| | rpa2 | Replication protein A2. (278 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa) |
| | uba52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (622 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa) |
| | lig4 | DNA ligase. (914 aa) |
| | apbb1 | Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (686 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1519 aa) |
| | xrcc2 | RECA_2 domain-containing protein. (308 aa) |
| | LOC111229324 | Importin subunit alpha; Belongs to the importin alpha family. (537 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (377 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (604 aa) |
| | blm | BLM RecQ like helicase. (1392 aa) |
| | tdp2 | Tyrosyl-DNA phosphodiesterase 2b. (399 aa) |
| | LOC111228832 | Zgc:110269. (344 aa) |
| | LOC111232664 | Transmembrane protein 182b. (242 aa) |
| | xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (648 aa) |
| | ENSSDUP00000015520 | BRCA2 DNA repair associated. (3048 aa) |
| | polh | Polymerase (DNA directed), eta. (690 aa) |
| | atm | Non-specific serine/threonine protein kinase. (2999 aa) |
| | ENSSDUP00000016000 | RPA_C domain-containing protein. (250 aa) |
| | LOC111226716 | Uncharacterized protein. (245 aa) |
| | ppp4r2 | Protein phosphatase 4, regulatory subunit 2b. (441 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2248 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (529 aa) |
| | ENSSDUP00000017647 | Histone H2B; Belongs to the histone H2B family. (139 aa) |
| | ENSSDUP00000017713 | annotation not available (93 aa) |
| | eya1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (587 aa) |
| | rcbtb2 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | LOC111221389 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2076 aa) |
| | eya4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (614 aa) |
| | ENSSDUP00000018183 | RecQ helicase-like 4. (749 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (567 aa) |
| | LOC111228782 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (132 aa) |
| | smarca5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1032 aa) |
| | LOC111236357 | Small ubiquitin-related modifier. (96 aa) |
| | LOC111233015 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (377 aa) |
| | LOC111238179 | Uncharacterized protein. (416 aa) |
| | ENSSDUP00000027840 | Uncharacterized protein; Belongs to the histone H2B family. (117 aa) |
| | dntt | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (498 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa) |
| | ENSSDUP00000027074 | Uncharacterized protein. (204 aa) |
| | ENSSDUP00000027057 | Chromo_2 domain-containing protein. (702 aa) |
| | LOC111235454 | RAD51 paralog C. (351 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1488 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1045 aa) |
| | chek2 | Checkpoint kinase 2. (534 aa) |
| | rhno1 | Si:ch73-352p4.5. (262 aa) |
| | rmi2 | RecQ mediated genome instability 2. (166 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (383 aa) |
| | Nhej1 | Nonhomologous end-joining factor 1. (225 aa) |
| | KPNA2 | Importin subunit alpha; Belongs to the importin alpha family. (521 aa) |
| | LOC111230319 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (873 aa) |
| | ube2n | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | ENSSDUP00000024652 | Endo/exonuclease/phosphatase domain-containing protein. (350 aa) |
| | LOC111218242 | Small ubiquitin-related modifier. (95 aa) |
| | LOC111238046 | Importin subunit alpha; Belongs to the importin alpha family. (523 aa) |
| | slf1 | SMC5-SMC6 complex localization factor 1. (857 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | LOC111230957 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | xrcc5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (726 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | pold1 | DNA polymerase. (1121 aa) |
| | ubc | Uncharacterized protein. (748 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (343 aa) |
| | LOC111233560 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (476 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (279 aa) |
| | ENSSDUP00000022505 | Histone domain-containing protein; Belongs to the histone H2B family. (121 aa) |
| | ENSSDUP00000022496 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (680 aa) |
| | xrcc4 | Uncharacterized protein. (298 aa) |
| | rad1 | RAD1 homolog (S. pombe). (277 aa) |
| | ENSSDUP00000022246 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | kxd1 | KxDL motif containing 1. (184 aa) |
| | ENSSDUP00000022019 | Histone domain-containing protein; Belongs to the histone H2B family. (116 aa) |
| | polk | Polymerase (DNA directed) kappa. (884 aa) |
| | rif1 | Replication timing regulatory factor 1. (2285 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (430 aa) |
| | ENSSDUP00000021729 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa) |
| | abraxas1 | Abraxas 1, BRCA1 A complex subunit. (361 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (526 aa) |
| | ENSSDUP00000021478 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | ENSSDUP00000021373 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa) |
| | ENSSDUP00000021155 | Reverse transcriptase domain-containing protein. (1217 aa) |
| | sirt6 | Sirtuin 6. (350 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | ccna1 | Cyclin A1; Belongs to the cyclin family. (410 aa) |
| | SUMO3 | Small ubiquitin-related modifier. (94 aa) |
| | LOC111224843 | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (657 aa) |
| | ENSSDUP00000018600 | Histone H2B; Belongs to the histone H2B family. (114 aa) |
