STRINGSTRING
ENSSDUP00000000054 ENSSDUP00000000054 uimc1 uimc1 brca1 brca1 ENSSDUP00000029876 ENSSDUP00000029876 mre11 mre11 ENSSDUP00000029566 ENSSDUP00000029566 rad50 rad50 baz1b baz1b smarca5 smarca5 LOC111233015 LOC111233015 ENSSDUP00000027840 ENSSDUP00000027840 tp53bp1 tp53bp1 chek2 chek2 babam2 babam2 KPNA2 KPNA2 LOC111230319 LOC111230319 ube2n ube2n ube2v2 ube2v2 ENSSDUP00000024652 ENSSDUP00000024652 LOC111238046 LOC111238046 LOC111230957 LOC111230957 ubc ubc LOC111233560 LOC111233560 ENSSDUP00000022505 ENSSDUP00000022505 ENSSDUP00000022496 ENSSDUP00000022496 ENSSDUP00000022246 ENSSDUP00000022246 kxd1 kxd1 ENSSDUP00000022019 ENSSDUP00000022019 ENSSDUP00000021729 ENSSDUP00000021729 abraxas1 abraxas1 ENSSDUP00000021478 ENSSDUP00000021478 ENSSDUP00000021373 ENSSDUP00000021373 ENSSDUP00000021155 ENSSDUP00000021155 ENSSDUP00000018853 ENSSDUP00000018853 ENSSDUP00000018600 ENSSDUP00000018600 LOC111228782 LOC111228782 eya4 eya4 LOC111221389 LOC111221389 eya1 eya1 ENSSDUP00000017713 ENSSDUP00000017713 ENSSDUP00000017647 ENSSDUP00000017647 atm atm kat5 kat5 babam1 babam1 ENSSDUP00000001025 ENSSDUP00000001025 ENSSDUP00000001040 ENSSDUP00000001040 ppp5c ppp5c LOC111235132 LOC111235132 Brcc3 Brcc3 ube2i ube2i rps27a rps27a rnf8 rnf8 nsd2 nsd2 abl1 abl1 ENSSDUP00000006700 ENSSDUP00000006700 ENSSDUP00000006905 ENSSDUP00000006905 LOC111221313 LOC111221313 ENSSDUP00000007129 ENSSDUP00000007129 ENSSDUP00000007300 ENSSDUP00000007300 pias4 pias4 ENSSDUP00000007804 ENSSDUP00000007804 LOC111224648 LOC111224648 rnf169 rnf169 ENSSDUP00000008454 ENSSDUP00000008454 ubb ubb ankrd11 ankrd11 eya3 eya3 LOC111230935 LOC111230935 sumo1 sumo1 ankrd12 ankrd12 ENSSDUP00000012931 ENSSDUP00000012931 uba52 uba52 apbb1 apbb1 LOC111229324 LOC111229324
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSSDUP00000000054Histone H2B; Belongs to the histone H2B family. (131 aa)
uimc1RAP80_UIM domain-containing protein. (1088 aa)
brca1Uncharacterized protein. (1251 aa)
ENSSDUP00000029876Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (696 aa)
ENSSDUP00000029566Histone H2B; Belongs to the histone H2B family. (114 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
baz1bBromodomain adjacent to zinc finger domain, 1B. (1656 aa)
smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1032 aa)
LOC111233015Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (377 aa)
ENSSDUP00000027840Uncharacterized protein; Belongs to the histone H2B family. (117 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1488 aa)
chek2Checkpoint kinase 2. (534 aa)
babam2BRISC and BRCA1 A complex member 2. (383 aa)
KPNA2Importin subunit alpha; Belongs to the importin alpha family. (521 aa)
LOC111230319UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
ube2nUbiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
ENSSDUP00000024652Endo/exonuclease/phosphatase domain-containing protein. (350 aa)
LOC111238046Importin subunit alpha; Belongs to the importin alpha family. (523 aa)
LOC111230957Histone H2B; Belongs to the histone H2B family. (124 aa)
ubcUncharacterized protein. (748 aa)
LOC111233560Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (476 aa)
ENSSDUP00000022505Histone domain-containing protein; Belongs to the histone H2B family. (121 aa)
ENSSDUP00000022496Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
ENSSDUP00000022246Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
kxd1KxDL motif containing 1. (184 aa)
ENSSDUP00000022019Histone domain-containing protein; Belongs to the histone H2B family. (116 aa)
ENSSDUP00000021729Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (361 aa)
ENSSDUP00000021478Histone H2B; Belongs to the histone H2B family. (116 aa)
ENSSDUP00000021373Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
ENSSDUP00000021155Reverse transcriptase domain-containing protein. (1217 aa)
ENSSDUP00000018853Endo/exonuclease/phosphatase domain-containing protein. (404 aa)
ENSSDUP00000018600Histone H2B; Belongs to the histone H2B family. (114 aa)
LOC111228782Ubiquitin A-52 residue ribosomal protein fusion product 1. (132 aa)
eya4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (614 aa)
LOC111221389Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (587 aa)
ENSSDUP00000017713annotation not available (93 aa)
ENSSDUP00000017647Histone H2B; Belongs to the histone H2B family. (139 aa)
atmNon-specific serine/threonine protein kinase. (2999 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (604 aa)
babam1BRISC and BRCA1 A complex member 1. (377 aa)
ENSSDUP00000001025Histone H2B; Belongs to the histone H2B family. (116 aa)
ENSSDUP00000001040Uncharacterized protein; Belongs to the histone H2B family. (67 aa)
ppp5cSerine/threonine-protein phosphatase. (491 aa)
LOC111235132Ubiquitin-conjugating enzyme E2 variant 1. (147 aa)
Brcc3BRCA1/BRCA2-containing complex, subunit 3. (280 aa)
ube2iUbiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (175 aa)
rps27aRibosomal protein S27a. (156 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (560 aa)
nsd2Nuclear receptor binding SET domain protein 2. (1337 aa)
abl1Tyrosine-protein kinase. (1118 aa)
ENSSDUP00000006700Ring finger protein 168. (397 aa)
ENSSDUP00000006905Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
LOC111221313Histone H2B; Belongs to the histone H2B family. (123 aa)
ENSSDUP00000007129Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSSDUP00000007300Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (90 aa)
pias4Protein inhibitor of activated STAT, 4a. (507 aa)
ENSSDUP00000007804Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC111224648UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
rnf169Ring finger protein 169. (597 aa)
ENSSDUP00000008454Reverse transcriptase domain-containing protein. (1306 aa)
ubbUncharacterized protein. (153 aa)
ankrd11Ankyrin repeat domain 11. (2846 aa)
eya3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (604 aa)
LOC111230935Lysine (K)-specific demethylase 4B. (1235 aa)
sumo1Small ubiquitin-related modifier. (101 aa)
ankrd12Ankyrin repeat domain 12. (1958 aa)
ENSSDUP00000012931ANK_REP_REGION domain-containing protein. (674 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
apbb1Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (686 aa)
LOC111229324Importin subunit alpha; Belongs to the importin alpha family. (537 aa)
Your Current Organism:
Seriola dumerili
NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack
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