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| | ENSSDUP00000021729 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa) |
| | ENSSDUP00000022019 | Histone domain-containing protein; Belongs to the histone H2B family. (116 aa) |
| | ENSSDUP00000022246 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | rad1 | RAD1 homolog (S. pombe). (277 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (680 aa) |
| | ENSSDUP00000022496 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa) |
| | ENSSDUP00000022505 | Histone domain-containing protein; Belongs to the histone H2B family. (121 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (279 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | LOC111230957 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | LOC111218242 | Small ubiquitin-related modifier. (95 aa) |
| | ENSSDUP00000024652 | Endo/exonuclease/phosphatase domain-containing protein. (350 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | ube2n | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | LOC111230319 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (383 aa) |
| | rmi2 | RecQ mediated genome instability 2. (166 aa) |
| | rhno1 | Si:ch73-352p4.5. (262 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1045 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1488 aa) |
| | ENSSDUP00000027840 | Uncharacterized protein; Belongs to the histone H2B family. (117 aa) |
| | LOC111238179 | Uncharacterized protein. (416 aa) |
| | LOC111236357 | Small ubiquitin-related modifier. (96 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | LOC111237550 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa) |
| | atrip | Uncharacterized protein. (802 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (696 aa) |
| | ENSSDUP00000029876 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa) |
| | brca1 | Uncharacterized protein. (1251 aa) |
| | exo1 | Exonuclease 1. (797 aa) |
| | uimc1 | RAP80_UIM domain-containing protein. (1088 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (732 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (359 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (387 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (311 aa) |
| | ENSSDUP00000029566 | Histone H2B; Belongs to the histone H2B family. (114 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | blm | BLM RecQ like helicase. (1392 aa) |
| | atm | Non-specific serine/threonine protein kinase. (2999 aa) |
| | ENSSDUP00000016000 | RPA_C domain-containing protein. (250 aa) |
| | ppp4r2 | Protein phosphatase 4, regulatory subunit 2b. (441 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2248 aa) |
| | ENSSDUP00000017647 | Histone H2B; Belongs to the histone H2B family. (139 aa) |
| | ENSSDUP00000017713 | annotation not available (93 aa) |
| | rcbtb2 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | LOC111221389 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | ENSSDUP00000018183 | RecQ helicase-like 4. (749 aa) |
| | ENSSDUP00000018600 | Histone H2B; Belongs to the histone H2B family. (114 aa) |
| | ENSSDUP00000018853 | Endo/exonuclease/phosphatase domain-containing protein. (404 aa) |
| | SUMO3 | Small ubiquitin-related modifier. (94 aa) |
| | ccna1 | Cyclin A1; Belongs to the cyclin family. (410 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa) |
| | sirt6 | Sirtuin 6. (350 aa) |
| | ENSSDUP00000021155 | Reverse transcriptase domain-containing protein. (1217 aa) |
| | ENSSDUP00000021373 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (405 aa) |
| | timeless | Timeless circadian clock. (1255 aa) |
| | ENSSDUP00000006700 | Ring finger protein 168. (397 aa) |
| | LOC111221313 | Histone H2B; Belongs to the histone H2B family. (123 aa) |
| | ENSSDUP00000007129 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | ENSSDUP00000007300 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (90 aa) |
| | pias4 | Protein inhibitor of activated STAT, 4a. (507 aa) |
| | ENSSDUP00000007804 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | LOC111224648 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | rnf169 | Ring finger protein 169. (597 aa) |
| | ENSSDUP00000008454 | Reverse transcriptase domain-containing protein. (1306 aa) |
| | Rbbp8 | SAE2 domain-containing protein. (86 aa) |
| | ankrd11 | Ankyrin repeat domain 11. (2846 aa) |
| | ENSSDUP00000021478 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | abraxas1 | Abraxas 1, BRCA1 A complex subunit. (361 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (560 aa) |
| | nsd2 | Nuclear receptor binding SET domain protein 2. (1337 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (635 aa) |
| | ankrd12 | Ankyrin repeat domain 12. (1958 aa) |
| | ccna2 | Cyclin A2; Belongs to the cyclin family. (437 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (604 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (377 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1519 aa) |
| | rpa2 | Replication protein A2. (278 aa) |
| | ENSSDUP00000012931 | ANK_REP_REGION domain-containing protein. (674 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | dna2 | DNA replication helicase/nuclease 2. (1406 aa) |
| | ENSSDUP00000000054 | Histone H2B; Belongs to the histone H2B family. (131 aa) |
| | ENSSDUP00000001025 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | ENSSDUP00000001040 | Uncharacterized protein; Belongs to the histone H2B family. (67 aa) |
| | LOC111235132 | Ubiquitin-conjugating enzyme E2 variant 1. (147 aa) |
| | Brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (280 aa) |
| | ube2i | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (175 aa) |
| | sumo2 | Small ubiquitin-related modifier. (95 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (330 aa) |
