44 items (Seriola dumerili) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
	ercc8	Excision repair cross-complementation group 8. (400 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	ddb1	Damage-specific DNA binding protein 1. (1140 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (751 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (834 aa)
	ercc5	Excision repair cross-complementation group 5. (1139 aa)
	pold4	Si:dkey-28b4.7. (108 aa)
	ddb2	Damage-specific DNA binding protein 2. (496 aa)
	LOC111226567	Centrin, EF-hand protein, 2. (191 aa)
	rad23a	RAD23 homolog A, nucleotide excision repair protein a. (371 aa)
	ercc4	Excision repair cross-complementation group 4. (901 aa)
	LOC111229339	General transcription factor IIH subunit. (392 aa)
	rpa2	Replication protein A2. (278 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (275 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (554 aa)
	ENSSDUP00000016000	RPA_C domain-containing protein. (250 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
	rpa3	Replication protein A3. (122 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2076 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	cdk7	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (526 aa)
	RAD23B	RAD23 homolog B, nucleotide excision repair protein. (391 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (680 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (319 aa)
	ercc1	Excision repair cross-complementation group 1. (357 aa)
	pold1	DNA polymerase. (1121 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	LOC111231859	RAD23 homolog A, nucleotide excision repair protein b. (474 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	mnat1	MNAT1 component of CDK activating kinase. (372 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (550 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (146 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (300 aa)
	lig1	DNA ligase. (616 aa)
	ercc3	Excision repair cross-complementation group 3. (783 aa)
	rfc1	Replication factor C subunit 1. (1181 aa)
	rfc4	Replication factor C (activator 1) 4. (359 aa)
	ercc6	Excision repair cross-complementation group 6. (1036 aa)
	rfc2	Replication factor C (activator 1) 2. (387 aa)

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSDUP00000016000	LOC111226567	ENSSDUP00000016000	ENSSDUP00000010295	RPA_C domain-containing protein.	Centrin, EF-hand protein, 2.	0.506
ENSSDUP00000016000	LOC111229339	ENSSDUP00000016000	ENSSDUP00000013072	RPA_C domain-containing protein.	General transcription factor IIH subunit.	0.647
ENSSDUP00000016000	LOC111231859	ENSSDUP00000016000	ENSSDUP00000026602	RPA_C domain-containing protein.	RAD23 homolog A, nucleotide excision repair protein b.	0.430
ENSSDUP00000016000	RAD23B	ENSSDUP00000016000	ENSSDUP00000021619	RPA_C domain-containing protein.	RAD23 homolog B, nucleotide excision repair protein.	0.444
ENSSDUP00000016000	RPA1	ENSSDUP00000016000	ENSSDUP00000022462	RPA_C domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.988
ENSSDUP00000016000	cul4a	ENSSDUP00000016000	ENSSDUP00000007295	RPA_C domain-containing protein.	Cullin 4A; Belongs to the cullin family.	0.471
ENSSDUP00000016000	cul4b	ENSSDUP00000016000	ENSSDUP00000008000	RPA_C domain-containing protein.	Cullin 4B; Belongs to the cullin family.	0.471
ENSSDUP00000016000	ddb1	ENSSDUP00000016000	ENSSDUP00000006352	RPA_C domain-containing protein.	Damage-specific DNA binding protein 1.	0.564
ENSSDUP00000016000	ddb2	ENSSDUP00000016000	ENSSDUP00000009953	RPA_C domain-containing protein.	Damage-specific DNA binding protein 2.	0.709
ENSSDUP00000016000	ercc1	ENSSDUP00000016000	ENSSDUP00000023105	RPA_C domain-containing protein.	Excision repair cross-complementation group 1.	0.672
ENSSDUP00000016000	ercc2	ENSSDUP00000016000	ENSSDUP00000003205	RPA_C domain-containing protein.	Excision repair cross-complementation group 2.	0.627
ENSSDUP00000016000	ercc3	ENSSDUP00000016000	ENSSDUP00000029414	RPA_C domain-containing protein.	Excision repair cross-complementation group 3.	0.539
ENSSDUP00000016000	ercc4	ENSSDUP00000016000	ENSSDUP00000011769	RPA_C domain-containing protein.	Excision repair cross-complementation group 4.	0.757
ENSSDUP00000016000	ercc5	ENSSDUP00000016000	ENSSDUP00000008670	RPA_C domain-containing protein.	Excision repair cross-complementation group 5.	0.580
ENSSDUP00000016000	gtf2h1	ENSSDUP00000016000	ENSSDUP00000027242	RPA_C domain-containing protein.	General transcription factor IIH, polypeptide 1.	0.544
ENSSDUP00000016000	gtf2h3	ENSSDUP00000016000	ENSSDUP00000028973	RPA_C domain-containing protein.	General transcription factor IIH, polypeptide 3.	0.629
ENSSDUP00000016000	gtf2h5	ENSSDUP00000016000	ENSSDUP00000026875	RPA_C domain-containing protein.	General transcription factor IIH, polypeptide 5.	0.529
ENSSDUP00000016000	lig1	ENSSDUP00000016000	ENSSDUP00000029187	RPA_C domain-containing protein.	DNA ligase.	0.724
ENSSDUP00000016000	pcna	ENSSDUP00000016000	ENSSDUP00000004184	RPA_C domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.868
ENSSDUP00000016000	pold1	ENSSDUP00000016000	ENSSDUP00000023525	RPA_C domain-containing protein.	DNA polymerase.	0.706